Yatein
Yatein is a lignan isolated from A. chilensis, with antiproliferative activity. Yatein suppresses herpes simplex virus type 1 (HSV-1 ) replication by interruption the immediate-early gene expression.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 40456-50-6
- Fòrmula: C22H24O7
- Peso molecular:400.42
-
Almacenamiento:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Actividad biológica
|
HSV-1 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | ED50 |
>20 μg/mL
Compound: 5
|
Cytotoxicity against human A431 cells
Cytotoxicity against human A431 cells
|
[PMID: 8277312] |
| BC1 cell line | ED50 |
0.05 μg/mL
Compound: 5
|
Cytotoxicity against human BC1 cells
Cytotoxicity against human BC1 cells
|
[PMID: 8277312] |
| Col2 | ED50 |
0.08 μg/mL
Compound: 5
|
Cytotoxicity against human Col2 cells
Cytotoxicity against human Col2 cells
|
[PMID: 8277312] |
| HT | ED50 |
0.07 μg/mL
Compound: 5
|
Cytotoxicity against human HT cells
Cytotoxicity against human HT cells
|
[PMID: 8277312] |
| KB | ED50 |
0.08 μg/mL
Compound: 5
|
Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
|
[PMID: 8277312] |
| KB-V1 | ED50 |
0.06 μg/mL
Compound: 5
|
Cytotoxicity against human KBV1 cells
Cytotoxicity against human KBV1 cells
|
[PMID: 8277312] |
| LNCaP | ED50 |
0.16 μg/mL
Compound: 5
|
Cytotoxicity against human LNCAP cells
Cytotoxicity against human LNCAP cells
|
[PMID: 8277312] |
| Lu1 | ED50 |
0.1 μg/mL
Compound: 5
|
Cytotoxicity against human Lu1 cells
Cytotoxicity against human Lu1 cells
|
[PMID: 8277312] |
| P388 | ED50 |
0.4 μg/mL
Compound: 5
|
Cytotoxicity in mouse P388 cells
Cytotoxicity in mouse P388 cells
|
[PMID: 8277312] |
| U-373MG ATCC | ED50 |
0.3 μg/mL
Compound: 5
|
Cytotoxicity against human U373 cells
Cytotoxicity against human U373 cells
|
[PMID: 8277312] |
| ZR-75-1 | ED50 |
0.5 μg/mL
Compound: 5
|
Cytotoxicity against human ZR-75-1 cells
Cytotoxicity against human ZR-75-1 cells
|
[PMID: 8277312] |
Yatein induces cell-cycle arrest at G2/M phase (5 μM; 24 hours) and enhances G2/M phase-related protein expression (5 μM; 6-12 hours) in human lung adenocarcinoma A549 and CL1-5 cells[3].
Yatein (5 μM; 6-12 hours) induces DNA damage through activation of the ATM/ATR pathway in human A549 and CL1-5 cells[3].
Yatein (5 μM; 6 hours) affects microtubule dynamics by inhibiting tubulin polymerization[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:A549 cells, CL1-5 cells
-
Concentration:1.25 μM , 2.5 μM , 5 μM
-
Incubation Time:24 hours
-
Result:Induced cell-cycle arrest at G2/M phase in both cell lines.
-
Cell Line:A549 cells, CL1-5 cells
-
Concentration:5 μM
-
Incubation Time:6 hours, 12 hours
-
Result:Upregulated the expression of cyclin B1, but not Cdc2 and Cdc25c, induced Cdc2 phosphorylation.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Male NOD/SCID mice (6-8 weeks), with A549 cells xenograft[3]
-
Dosage:20 mg/kg
-
Administration:Intraperitoneal injection, five times per week, for 42 days
-
Result:Significantly slowed tumor growth and moderately increased both cyclin B1 expression and Cdc2 phosphorylation.
Chemical Information
-
No. CAS 40456-50-6
-
Appearance Oil
-
Peso molecular 400.42
-
Fòrmula C22H24O7
-
Color Colorless to light yellow
-
SMILES
O=C1OC[C@H](CC2=CC=C(OCO3)C3=C2)[C@H]1CC4=CC(OC)=C(OC)C(OC)=C4
-
Structure Classification
-
Initial Source
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Pureza y Documentación
-
Ficha de datos (282 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Donoso-Fierro C, et al. Antiproliferative activity of yatein isolated from Austrocedrus chilensis against murine myeloma cells: cytological studies and chemical investigations. Pharm Biol. 2015 Mar;53(3):378-85. [Content Brief]
[2]. Kuo YC, et al. Yatein from Chamaecyparis obtusa suppresses herpes simplex virus type 1 replication in HeLa cells by interruption the immediate-early gene expression. Antiviral Res. 2006 Jul;70(3):112-20. [Content Brief]
[3]. Shang-Tse Ho, et al. Molecular Mechanisms Underlying Yatein-Induced Cell-Cycle Arrest and Microtubule Destabilization in Human Lung Adenocarcinoma Cells. Cancers (Basel). 2019 Sep; 11(9): 1384. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz