Ano1 - anoctamin 1, calcium activated chloride channel Gene

Also Known as Tmem16a

Species: Mus musculus

Gene Type: protein coding
Gene ID: 101772

Summary

Enables intracellular calcium activated Chloride Channel activity; protein homodimerization activity; and voltage-gated Chloride Channel activity. Involved in several processes, including chloride transmembrane transport; detection of temperature stimulus involved in sensory perception of pain; and positive regulation of Insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within regulation of membrane potential. Located in apical plasma membrane and external side of plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ANO1 (anoctamin 1). [provided by Alliance of Genome Resources, Apr 2022]

Ano1 Products (2)

mRNA Protein Name
NM_001242349.2 NP_001229278.2 anoctamin-1 isoform 2
NM_178642.6 NP_848757.5 anoctamin-1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chloride channel activity IDA
IDA: Inferred from direct assay
25779870 MGI
enables chloride channel activity IMP
IMP: Inferred from mutant phenotype
24885604 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
23576756 MGI
enables intracellularly calcium-gated chloride channel activity IDA
IDA: Inferred from direct assay
18724360 MGI
NOT enables phospholipid scramblase activity IDA
IDA: Inferred from direct assay
23532839 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23576756 MGI
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
28561733 MGI
enables voltage-gated chloride channel activity IDA
IDA: Inferred from direct assay
22634729 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to heat IDA
IDA: Inferred from direct assay
22634729 MGI
involved in chloride transmembrane transport IDA
IDA: Inferred from direct assay
22634729 MGI
involved in chloride transmembrane transport IMP
IMP: Inferred from mutant phenotype
24885604 MGI
acts upstream of or within chloride transport IDA
IDA: Inferred from direct assay
20056604 MGI
involved in chloride transport IDA
IDA: Inferred from direct assay
18724360 MGI
involved in chloride transport IMP
IMP: Inferred from mutant phenotype
28963502 MGI
NOT involved in detection of mechanical stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
22634729 MGI
involved in detection of temperature stimulus involved in sensory perception of pain IGI
IGI: Inferred from genetic interaction
22634729 MGI
involved in detection of temperature stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
22634729 MGI
acts upstream of or within establishment of localization in cell IDA
IDA: Inferred from direct assay
23532839 MGI
involved in glial cell projection elongation IMP
IMP: Inferred from mutant phenotype
31147466 MGI
involved in mucus secretion IMP
IMP: Inferred from mutant phenotype
30586313 MGI
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
22634729 MGI
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
24885604 MGI
acts upstream of or within regulation of membrane potential IGI
IGI: Inferred from genetic interaction
23133519 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
23133519 MGI
involved in trachea development IMP
IMP: Inferred from mutant phenotype
18585372 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
21516098 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
23576756 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
23840801 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
18585372 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
23840801 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

anoctamin-1

  • transmembrane protein 16A

Ano1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ano1 Q8BHY3 Ano1 Mus musculus Q8BHY3
3D-EM-Single
29236691
Intra
Ano1 Q8BHY3 Ano1 Mus musculus Q8BHY3
3D-EM
29236684
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-119981 Ani9 Inhibitor 99.12% Unkown
HY-100612 T16Ainh-A01 Inhibitor 99.04% Unkown
HY-146320 ANO1-IN-1 Inhibitor 99.57% Unkown
HY-105917 Emidurdar Inhibitor 99.41% Yes
HY-146334 DFBTA Inhibitor 99.25% Unkown
HY-153508 ANO1-IN-4 Inhibitor 99.58% Unkown
HY-118170 T16A(inh)-C01 Inhibitor 90% Unkown
HY-N5101 Kobusin 99.93% Unkown
HY-146321 ANO1-IN-2 Inhibitor / Unkown
HY-147874 ANO1-IN-3 / Unkown
HY-175669 ANO1-IN-5 Inhibitor / Unkown
HY-RS00740 ANO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00750 ANOS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-114457 Phosphatidylinositol 4,5-bisphosphate Substrate / Unkown
HY-RS17326 Ano1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23781 Ano1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990337 Anti-ANO1/TMEM16A Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ano1 NCBI NCBI:55107