Topors - topoisomerase I binding, arginine/serine-rich Gene

Also Known as LUN; TP53BPL; p53BP3/LUN

Species: Mus musculus

Gene Type: protein coding
Gene ID: 106021

Summary

Predicted to enable several functions, including DNA Topoisomerase binding activity; antigen binding activity; and ubiquitin-like protein transferase activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; positive regulation of transcription, DNA-templated; and regulation of cell population proliferation. Located in ciliary basal body; nucleus; and photoreceptor connecting cilium. Is expressed in skin. Human ortholog(s) of this gene implicated in retinitis pigmentosa 31. Orthologous to human TOPORS (TOP1 binding arginine/serine rich protein, E3 ubiquitin Ligase). [provided by Alliance of Genome Resources, Apr 2022]

Topors Products (1)

mRNA Protein Name
NM_134097.3 NP_598858.2 E3 ubiquitin-protein ligase Topors

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15735665 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA damage response IDA
IDA: Inferred from direct assay
15735665 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
IDA: Inferred from direct assay
15735665 MGI
acts upstream of or within positive regulation of DNA-templated transcription IGI
IGI: Inferred from genetic interaction
15735665 MGI
acts upstream of or within regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15735665 MGI
Cellular Component GO Annotation Evidence References Source
located in ciliary basal body IDA
IDA: Inferred from direct assay
21159800 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15735665 MGI
located in photoreceptor connecting cilium IDA
IDA: Inferred from direct assay
21159800 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase Topors

  • RING-type E3 ubiquitin transferase Topors

  • SUMO1-protein E3 ligase Topors

  • p53-binding protein 3

  • p53BP3

  • topoisomerase 1-binding RING finger

  • topoisomerase I-binding RING finger protein

  • topoisomerase I-binding arginine/serine-rich protein

  • tumor suppres

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-164734 Raludotatug Deruxtecan 99.29% Phase 3
HY-171689 Puxitatug samrotecan Inhibitor 98.51% Phase 2
HY-168739 Topoisomerase I inhibitor 17 / Phase 2
HY-171124 Tilatamig samrotecan Inhibitor 95.26% Phase 1
HY-U00248 LMP744 Inhibitor 98.33% Phase 1
HY-18350 Indimitecan Inhibitor 98.30% Phase 1
HY-U00248A LMP744 hydrochloride Inhibitor 99.08% Phase 1

Pre-clinical Phase

Bioactive Molecules (82)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-148819A NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride Inhibitor 98.46% Unkown
HY-148819 NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT Inhibitor 98.71% Unkown
HY-111630 PluriSIn #2 Inhibitor 98.0% Unkown
HY-174374 Topobexin Inhibitor 99.04% Unkown
HY-118581 Coralyne chloride Inhibitor 98.39% Unkown
HY-163099 P5(PEG24)-VC-PAB-Exatecan 99.74% Unkown
HY-153278 Q901 Inhibitor 98.38% Unkown
HY-164143 T638 Inhibitor 98.61% Unkown
HY-116785 BRD32048 Inhibitor 99.94% Unkown
HY-153278A Q901 TFA Inhibitor / Unkown
HY-160005 LMP517 Inhibitor 99.58% Unkown
HY-175203 Topi MF-6 Inhibitor 99.79% Unkown
HY-122594 BNS-22 Inhibitor 99.50% Unkown
HY-W008874 meso-Tetra(4-pyridyl)porphine Inhibitor ≥97.0% Unkown
HY-118911 ATM Inhibitor-10 Inhibitor 98.7% Unkown
HY-N0114A (±)-Evodiamine 99.74% Unkown
HY-123393 PNU-142586 Inhibitor / Unkown
HY-13550 Ametantrone Inhibitor 97.28% Unkown
HY-160857 TOP5668 Agonist 98.07% Unkown
HY-168489 OBI-992 drug-linker 96.64% Unkown
HY-RS14902 TOPORS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14894 TOP2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-126142 Top1 inhibitor 1 Inhibitor 99.67% Unkown
HY-RS14893 TOP1MT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14897 TOP2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14899 TOP3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-118942 Topovale Inhibitor 99.94% Unkown
HY-101115 PI3K-IN-6 Inhibitor / Unkown
HY-117142 Quizalofop-P Inhibitor / Unkown
HY-117613 A-74932 hydrochloride Inhibitor / Unkown
HY-120638 BMS-250749 Inhibitor / Unkown
HY-121560 L-leucyldoxorubicin / Unkown
HY-121866 CP-84364 Inhibitor / Unkown
HY-125387 TOP1210 / Unkown
HY-125426 ToP-DNJ Inhibitor / Unkown
HY-125500 TOP1362 Inhibitor / Unkown
HY-143265 Topoisomerase I inhibitor 2 / Unkown
HY-144222 NSC 828467 Inhibitor / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown
HY-145851 Top/HDAC-IN-1 / Unkown
HY-145852 Top/HDAC-IN-2 / Unkown
HY-146437 Topoisomerase I inhibitor 6 Inhibitor / Unkown
HY-149348 DiPT-4 / Unkown
HY-159935 Top1-IN-2 Inhibitor / Unkown
HY-159966 Top/HDAC-IN-3 / Unkown
HY-160856 TOP5300 Agonist / Unkown
HY-161957 Top1/2-IN-1 Inhibitor / Unkown
HY-163118 Topoisomerase II inhibitor 17 / Unkown
HY-16560B (R)-Camptothecin Control / Unkown
HY-172259 Toyaburgine Inhibitor / Unkown
HY-173001 AuL1 Inhibitor / Unkown
HY-175700 YCJ-02 / Unkown
HY-175834 DNA/TOP2A-IN-1 / Unkown
HY-176762 TOP3B-IN-1 Inhibitor / Unkown
HY-178029 RSK2/TOP2-IN-1 / Unkown
HY-178036 ZM484 Inhibitor / Unkown
HY-180555 SN38-(PEG)2-Pom-α Activator / Unkown
HY-181080 TOP1/TDP1-IN-1 / Unkown
HY-18350A Indimitecan hydrochloride Inhibitor / Unkown
HY-184245 Hsp90-IN-48 Inhibitor / Unkown
HY-N15249 4"-Isovalerylspiramycin I / Unkown
HY-N17442 Echinoside A / Unkown
HY-P11715 Abz-GFDPFRQ-EDDnp / Unkown
HY-P4926 Mca-SEVKMDAEFRK(Dnp)RR-NH2 / Unkown
HY-RS14890 TOP1 Human Pre-designed siRNA Set A / Unkown
HY-RS14891 Top1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS14892 Top1 Rat Pre-designed siRNA Set A / Unkown
HY-RS14895 Top2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14896 Top2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14898 TOP3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W654323 PNU-142586 sodium Inhibitor / Unkown
HY-W800535 Cryptolepine / Unkown
HY-133219 Guajadial C Inhibitor / Unkown
HY-160930 TOP1288 Inhibitor / Unkown
HY-169173 AL284 Inhibitor / Unkown
HY-180333 Top-Tdp tri inhibitor C12 / Unkown
HY-184297 Topoisomerase II-IN-26 Inhibitor / Unkown
HY-185300 IKZF2-degrader 4 Degrader / Unkown
HY-RS20119 Top2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21791 Top3a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26623 Top2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28307 Top3a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990947 Tilatamig Inhibitor 99.99% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Topors NCBI NCBI:10210