2. Gene
  3. TOPORS - TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase Gene

TOPORS - TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LUN; RP31; P53BP3; TP53BPL

Gene ID: 10210 | Gene type: protein coding

About TOPORS

Cytogenetic location: 9p21.1 Genomic coordinates (GRCh38): 9:32,540,544-32,552,586 (from NCBI)

This gene has 2 transcripts (splice variants), 252 orthologues and is associated with 4 phenotypes. Ubiquitous expression in testis (RPKM 10.5), bone marrow (RPKM 10.0) and 25 other tissues.

Summary

This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]

TOPORS Products(2)

mRNA Protein Name
NM_001195622.2 NP_001182551.1 E3 ubiquitin-protein ligase Topors isoform 2
NM_005802.5 NP_005793.2 E3 ubiquitin-protein ligase Topors isoform 1

TOPORS Protein Structure

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (103 - 141)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1045 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase Topors

RING-type E3 ubiquitin transferase Topors

Related Diseases

Diseases Alias
Retinitis Pigmentosa 31

RP31

Retinitis Pigmentosa-31

Retinitis Pigmentosa, Type 31
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Orofaciodigital Syndrome Vi

OFD6

Varadi-Papp Syndrome

Varadi Syndrome

Joubert Syndrome With Orofaciodigital Defect

Orofaciodigital Syndrome Type 6

Orofaciodigital Syndrome 6

Oral-Facial-Digital Syndrome, Type Vi

Ofds Vi

Polydactyly, Cleft Lip/Palate Or Lingual Lump, And Psychomotor Retardation

Polydactyly Cleft Lip Palate Psychomotor Retardation

Oral-Facial-Digital Syndrome Type 6

Polydactyly-Cleft Lip/Palate-Psychomotor Retardation Syndrome

Polydactyly - Cleft Lip/Palate - Psychomotor Retardation

Váradi Syndrome

Váradi-Papp Syndrome

Joubert Syndrome With Oral-Facial-Digital Syndrome

Oral-Facial-Digital Syndrome 6

Joubert-Orofaciodigital Syndrome

Orofaciodigital Syndrome, Type Vi
Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
Retinitis
Cold-Induced Sweating Syndrome 3
Retinitis Pigmentosa 74

RP74

Retinitis Pigmentosa, Type 74
Retinal Degeneration

Degeneration Of Retina
Renal-Hepatic-Pancreatic Dysplasia

Ivemark'S Syndrome

Ivemark Ii Syndrome

Renohepaticopancreatic Dysplasia
Choroidal Dystrophy, Central Areolar, 1

Choroidal Sclerosis

Choroidal Dystrophy

Choroidal Dystrophy, Central Areolar

Cacd

Central Areolar Choroidal Dystrophy

CACD1

Choroidal Dystrophy, Central Areolar 1

Choroidal Dystrophy Central Areolar

Central Areolar Choroidal Sclerosis

Choroidal Degenerations

Areolar Atrophy Of The Macula

Partial Central Choroid Dystrophy

Degenerative Choroidopathy

Chorioretinal Degeneration

Hereditary Chorioretinal Degeneration

Hereditary Degeneration Of Choroid

Hereditary Choroidal Dystrophies

Generalised Choroidal Dystrophy

Hereditary Choroidopathy
Usher Syndrome Type 2

Ush2

Usher Syndrome Type Ii
Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome

Dystrophia Retinae Pigmentosa-Dysostosis Syndrome

Graefe-Usher Syndrome

Hallgren Syndrome

Usher'S Syndrome

Retinitis Pigmentosa-Deafness Syndrome

Retinitis Pigmentosa-Hearing Loss Syndrome

Ush

Usher Syndromes
Leber Plus Disease

Leber Congenital Amaurosis

Lca

Leber'S Amaurosis

Leber'S Disease

Amaurosis Congenita Of Leber

Amaurosis Congenita Of Leber, Type 1

Lhon Plus Disease

Congenital Absence Of The Rods And Cones

Congenital Retinal Blindness

Crb

Congenital Amaurosis Of Retinal Origin

Leber'S Congenital Amaurosis

Leber Congenital Amaurosis 1

Leber'S Congenital Tapetoretinal Degeneration

Leber'S Congenital Tapetoretinal Dysplasia

Lca1

Leber Congenital Amaurosis Type 1

Retinal Blindness, Congenital

Amaurosis, Leber Congenital

Dysgenesis Neuroepithelialis Retinae

Hereditary Epithelial Dysplasia Of Retina

Hereditary Retinal Aplasia

Heredoretinopathia Congenitalis

Leber Abiotrophy

Leber Congenital Tapetoretinal Degeneration

Lebers Congenital Amaurosis

Optic Atrophy, Hereditary, Leber
Bardet-Biedl Syndrome

Bbs

Biedl-Bardet Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-U00248A LMP744 hydrochloride Inhibitor 99.70% Phase 1
HY-U00248 LMP744 Inhibitor 97.00% Phase 1
Pre-clinical Phase
Bioactive Molecules (37)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-111630 PluriSIn #2 Inhibitor ≥98.0% Unkown
HY-118581 Coralyne chloride Inhibitor 99.34% Unkown
HY-116785 BRD32048 Inhibitor 99.77% Unkown
HY-N0114A (±)-Evodiamine 99.97% Unkown
HY-18350 Indimitecan Inhibitor 98.03% Unkown
HY-101115 PI3K-IN-6 Inhibitor / Unkown
HY-117142 Quizalofop-P Inhibitor / Unkown
HY-118911 ATM Inhibitor-10 Inhibitor / Unkown
HY-122594 BNS-22 Inhibitor / Unkown
HY-126142 Top1 inhibitor 1 Inhibitor / Unkown
HY-13550 Ametantrone Inhibitor / Unkown
HY-143265 Topoisomerase I inhibitor 2 / Unkown
HY-144222 NSC 828467 Inhibitor / Unkown
HY-144654 HDAC/Top-IN-1 Inhibitor / Unkown
HY-145851 Top/HDAC-IN-1 / Unkown
HY-145852 Top/HDAC-IN-2 / Unkown
HY-146437 Topoisomerase I inhibitor 6 Inhibitor / Unkown
HY-149348 DiPT-4 / Unkown
HY-160005 LMP517 Inhibitor / Unkown
HY-160856 TOP5300 Agonist / Unkown
HY-160857 TOP5668 Agonist / Unkown
HY-163118 Topoisomerase II inhibitor 17 / Unkown
HY-N6621 Hippeastrine Inhibitor / Unkown
HY-RS14890 TOP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14891 Top1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14892 Top1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14893 TOP1MT Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14894 TOP2A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14895 Top2a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14896 Top2a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14897 TOP2B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14898 TOP3A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14899 TOP3B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14902 TOPORS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-118942 Topovale Inhibitor / Unkown
HY-133219 Guajadial C Inhibitor / Unkown
HY-160930 TOP1288 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TOPORS RGD RGD:1305270
Canis familiaris TOPORS VGNC VGNC:47712
Macaca mulatta TOPORS VGNC VGNC:79330
Mus musculus TOPORS MGD MGI:2146189
Felis catus TOPORS VGNC VGNC:66453
Bos taurus TOPORS VGNC VGNC:36222