Me2 - malic enzyme 2, NAD(+)-dependent, mitochondrial Gene

Also Known as NAD-ME; D030040L20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107029

Summary

Predicted to enable malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process; pyruvate metabolic process; and regulation of NADP metabolic process. Located in mitochondrion. Is expressed in several structures, including central nervous system; integumental system; metanephros; sensory organ; and skeleton. Orthologous to human ME2 (malic enzyme 2). [provided by Alliance of Genome Resources, Apr 2022]

Me2 Products (1)

mRNA Protein Name
NM_145494.3 NP_663469.1 NAD-dependent malic enzyme, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables malate dehydrogenase (decarboxylating) (NAD+) activity IDA
IDA: Inferred from direct assay
6725250 MGI
Biological Process GO Annotation Evidence References Source
involved in pyruvate metabolic process IDA
IDA: Inferred from direct assay
19691144 MGI
Cellular Component GO Annotation Evidence References Source
is active in mitochondrial matrix IDA
IDA: Inferred from direct assay
6725250 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

NAD-dependent malic enzyme, mitochondrial

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12033 2-Methoxyestradiol 99.82% Phase 2

Pre-clinical Phase

Bioactive Molecules (95)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15648B GSK-J4 99.67% Unkown
HY-D0858 MES 99.93% Unkown
HY-15227 EPZ004777 99.74% Unkown
HY-D0858A MES monohydrate 99.98% Unkown
HY-15648F GSK-J4 hydrochloride Inhibitor 99.01% Unkown
HY-15648 GSK-J1 Inhibitor 99.94% Unkown
HY-154812 Gintemetostat Inhibitor 99.81% Unkown
HY-W004588 tBu2bpy 99.39% Unkown
HY-162275 JMJD1C-IN-1 99.96% Unkown
HY-13808 UNC 0631 Inhibitor 99.27% Unkown
HY-152775 RK-701 Inhibitor 98.01% Unkown
HY-D0858C MES hydrate 99.90% Unkown
HY-157251 UNC8153 TFA Degrader 99.92% Unkown
HY-145103 UNC6934 Antagonist 98.24% Unkown
HY-D0858S MES-d13 99.93% Unkown
HY-13807 UNC0646 Inhibitor 99.38% Unkown
HY-D0858E MES potassium 99.88% Unkown
HY-15227A EPZ004777 hydrochloride 98.92% Unkown
HY-100360 MS049 Inhibitor 98.0% Unkown
HY-15648A GSK-J2 Control 99.75% Unkown
HY-66025 Fmoc-Lys(Me)2-OH hydrochloride 97.52% Unkown
HY-12033S2 2-Methoxyestradiol-d5 98.67% Unkown
HY-150510A MS8511 hydrochloride Inhibitor 98.07% Unkown
HY-161759 MS152 Inhibitor 99.36% Unkown
HY-162749A G9D-4 TFA 99.44% Unkown
HY-13808R UNC 0631 (Standard) Inhibitor 99.54% Unkown
HY-183058 EZM8266 Inhibitor 98.24% Unkown
HY-168992A UNC6535 TFA / Unkown
HY-156285 ZZM-1220 98.74% Unkown
HY-15648D GSK-J1 lithium salt Inhibitor 98.33% Unkown
HY-128579 DW14800 Inhibitor 99.12% Unkown
HY-150510 MS8511 Inhibitor / Unkown
HY-15313C CBB1007 trihydrochloride Inhibitor 97.08% Unkown
HY-157251A UNC8153 Degrader 99.61% Unkown
HY-161313 DYB-03 Inhibitor 99.49% Unkown
HY-164456 AMI-408 Inhibitor / Unkown
HY-D0858D MES hemisodium 98.0% Unkown
HY-116971 DCG066 99.78% Unkown
HY-120766 NCDM-32B Inhibitor 97.0% Unkown
HY-162749 G9D-4 / Unkown
HY-168992 UNC6535 Inhibitor / Unkown
HY-44062 G9a-IN-1 Inhibitor 98.12% Unkown
HY-P4895 (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin Antagonist 99.20% Unkown
HY-15313 CBB1007 Inhibitor / Unkown
HY-15313B CBB1007 hydrochloride Inhibitor 98.0% Unkown
HY-100360A MS049 dihydrochloride Inhibitor / Unkown
HY-168968S ZJY-54 Inhibitor / Unkown
HY-115619 EPZ004777 formate / Unkown
HY-12033S 2-Methoxyestradiol-13C,d3 / Unkown
HY-12033S1 2-Methoxyestradiol-13C6 / Unkown
HY-122595 EZH2-IN-1 Inhibitor / Unkown
HY-128931 NH2-Ph-C4-acid-NH2-Me / Unkown
HY-138604 5'-O-DMT-N6-Me-2'-dA Activator 98.00% Unkown
HY-148829 MS40 Degrader / Unkown
HY-154224 2’-O-Me-2-thio-U-3’-phos phoramidite / Unkown
HY-155817 UNC7096 Chemical / Unkown
HY-15648G GSK-J1 sodium Inhibitor / Unkown
HY-15648I GSK-J2 sodium Inhibitor / Unkown
HY-161787 G9a-IN-2 Inhibitor / Unkown
HY-168497 C-MS023 Inhibitor / Unkown
HY-173590 AW4 Inhibitor / Unkown
HY-175821 PRMT1-IN-3 / Unkown
HY-176283 Tubulin/LSD1-IN-1 / Unkown
HY-178378 G9a-IN-4 / Unkown
HY-179229 LSD1-IN-47 Inhibitor / Unkown
HY-179427 NSD2/H3K36me2 modulator-1 / Unkown
HY-179650 NSD2-PWWP1-IN-5 / Unkown
HY-179651 NSD2-PWWP1-IN-6 Inhibitor / Unkown
HY-180553 NSD2-IN-6 Inhibitor / Unkown
HY-183105 DC551040 / Unkown
HY-184500 TNG917 Inhibitor / Unkown
HY-187178 KDM2/7-IN-2 Inhibitor / Unkown
HY-187214 PROTAC G9a degrader-1 / Unkown
HY-P10819 S9-CMC1 TFA / Unkown
HY-P2014 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin Antagonist / Unkown
HY-P2253 H3K27(Me2) (15-34) / Unkown
HY-P4397 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin / Unkown
HY-RS02465 CELSR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08271 ME2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W657887 GSK-3β/G9a-IN-1 Inhibitor / Unkown
HY-134075 2-Amino-2'-O-methyladenosine / Unkown
HY-169217 CYP3A4-IN-4 Inhibitor / Unkown
HY-178568 DMTr-S-5-C-Me-2'-O-Me-rA(Bz)-3'-CE-phosphoramidite / Unkown
HY-178569 DMTr-S-5-C-Me-2'-O-Me-rC(Ac)-3'-CE-phosphoramidite / Unkown
HY-178643 DMTr-S-5-C-Me-2'-O-Me-rU-3'-CE-phosphoramidite / Unkown
HY-178660 DMTr-R-5'-C-Me-2'-O-Me-rA(Bz)-3'-CE-phosphoramidite / Unkown
HY-178663 DMTr-S-5-C-Me-2'-F-dA(Bz)-3'-CE-phosphoramidite / Unkown
HY-182110 5-Me-2'-Deoxyzebularine-CE phosphoramidite / Unkown
HY-D0858DR MES hemisodium (Standard) / Unkown
HY-P1162 (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin Antagonist / Unkown
HY-P5006 (d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin Antagonist / Unkown
HY-RS17416 Tcf4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17680 Me2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18501 Tcf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24141 Me2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Me2 NCBI NCBI:4200