UNC8153
Based on 1 Customer Validation
UNC8153 is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a Kd of 24 nM. UNC8153 reduces the cellular levels of both NSD2 protein (DC50 in cell U2OS is 0.35 μM) and the H3K36me2 chromatin mark. UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2.
For research use only. We do not sell to patients.
- Purity: 99.61%
- CAS No.: 2929304-60-7
- Formula: C33H37N5O5
- Molecular Weight:583.68
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
UNC8153 (0-20 μM, 96 h) exhibits anti-adhesion effect in KMS11 cell, and exhibits mild cytotoxicity against MM1S cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MM1S
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Concentration:0-50 μM
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Incubation Time:96 h
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Result:Inhibited the cell proliferation.
Chemical Information
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CAS No. 2929304-60-7
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Appearance Solid
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Molecular Weight 583.68
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Formula C33H37N5O5
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Color White to off-white
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SMILES
O=C(C1=CC=C2NC(COC2=C1)=O)N(CC3=CC=C(C(NC4=CC=C(C(NCCCCCCN)=O)C=C4)=O)C=C3)C5CC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (171.33 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7133 mL | 8.5663 mL | 17.1327 mL | 42.8317 mL |
| 5 mM | 0.3427 mL | 1.7133 mL | 3.4265 mL | 8.5663 mL | |
| 10 mM | 0.1713 mL | 0.8566 mL | 1.7133 mL | 4.2832 mL | |
| 15 mM | 0.1142 mL | 0.5711 mL | 1.1422 mL | 2.8554 mL | |
| 20 mM | 0.0857 mL | 0.4283 mL | 0.8566 mL | 2.1416 mL | |
| 25 mM | 0.0685 mL | 0.3427 mL | 0.6853 mL | 1.7133 mL | |
| 30 mM | 0.0571 mL | 0.2855 mL | 0.5711 mL | 1.4277 mL | |
| 40 mM | 0.0428 mL | 0.2142 mL | 0.4283 mL | 1.0708 mL | |
| 50 mM | 0.0343 mL | 0.1713 mL | 0.3427 mL | 0.8566 mL | |
| 60 mM | 0.0286 mL | 0.1428 mL | 0.2855 mL | 0.7139 mL | |
| 80 mM | 0.0214 mL | 0.1071 mL | 0.2142 mL | 0.5354 mL | |
| 100 mM | 0.0171 mL | 0.0857 mL | 0.1713 mL | 0.4283 mL |
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