ME2 - malic enzyme 2 Gene

Also Known as ODS1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4200

About ME2

Cytogenetic location: 18q21.2 Genomic coordinates (GRCh38): 18:50,879,118-50,954,257 (from NCBI)

This gene has 19 transcripts (splice variants), 212 orthologues and 2 paralogues. Ubiquitous expression in duodenum (RPKM 15.0), colon (RPKM 14.1) and 25 other tissues.

Summary

This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]

ME2 Products (2)

mRNA Protein Name
NM_001168335.2 NP_001161807.1 NAD-dependent malic enzyme, mitochondrial isoform 2 precursor
NM_002396.5 NP_002387.1 NAD-dependent malic enzyme, mitochondrial isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables malic enzyme activity IMP
IMP: Inferred from mutant phenotype
23334421 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of NADP metabolic process IMP
IMP: Inferred from mutant phenotype
23334421 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ME2 Protein Structure

malic

malic: Malic enzyme, N-terminal domain (89 - 270)

Malic_M

Malic_M: Malic enzyme, NAD binding domain (280 - 533)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 584 a.a.
Protein Preferred Names Protein Names

NAD-dependent malic enzyme, mitochondrial

  • NAD-ME

Recombinant ME2 Proteins

Cat. No. Product Name Accession Purity
HY-P71918A NAD-ME Protein, Human (His) P23368-1 (L19-E584) ≥ 95%, as determined by reducing SDS-PAGE.

ME2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83310 ME2 Antibody (YA3055) WB, ICC/IF Human, Mouse, Rat
HY-P83310A ME2 Antibody (YA3055)(PBS only) WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Epilepsy, Idiopathic Generalized

  • Idiopathic Generalized Epilepsy

  • Generalised Epilepsy

  • Epilepsy, Generalized

  • EIG

  • Ige

  • Epilepsy, Idiopathic Generalized, Susceptibility To, 1

  • Epilepsy, Idiopathic Generalized 1

  • Epilepsy, Idiopathic Generalized, Susceptibility To

  • Epilepsy, Idiopathic, Generalized

  • Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1
Epilepsy

  • Epilepsy Syndrome

  • Epileptic Syndrome

  • Epilepsies

  • Symptomatic Epilepsies

  • Post Traumatic Epilepsy

  • Traumatic Epilepsy

  • Traumatic Epileptic

  • Epilepsy Due To Hippocampal Sclerosis

  • Epilepsy With Ammon'S Horn Sclerosis

  • Epilepsy Due To Cortical Dysplasia

  • Epilepsy Due To Neuronal Migration Disorders
Epilepsy, Myoclonic Juvenile

  • Juvenile Myoclonic Epilepsy

  • Janz Syndrome

  • Jme

  • Myoclonic Epilepsy, Juvenile, Susceptibility To, 1

  • EJM

  • Myoclonic Epilepsy, Juvenile

  • Petit Mal, Impulsive

  • Myoclonic Epilepsy, Juvenile 1

  • Myoclonic Epilepsy, Juvenile, 1

  • Adolescent Myoclonic Epilepsy

  • Juvenile Myoclonus Epilepsy

  • Juvenile Myoclonic Epilepsy 1

  • EJM1

  • Petit Mal Impulsive

  • Susceptibility To Juvenile Myoclonic Epilepsy 1

  • Myoclonic Epilepsy Juvenile

  • Epilepsy, Myoclonic, Juvenile

  • Myoclonic Epilepsy Of Janz

  • Jme - [Juvenile Myoclonic Epilepsy]
Generalized Epilepsy With Febrile Seizures Plus

  • Gefs+

  • Genetic Epilepsy With Febrile Seizures Plus

  • Generalized Epilepsy With Febrile Seizures-Plus

  • Genetic Epilepsy With Febrile Seizures-Plus

  • Epilepsy, Generalized, With Febrile Seizures Plus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12033 2-Methoxyestradiol 99.82% Phase 2

Pre-clinical Phase

Bioactive Molecules (93)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15648B GSK-J4 99.67% Unkown
HY-D0858 MES 99.93% Unkown
HY-15227 EPZ004777 99.74% Unkown
HY-D0858A MES monohydrate 99.98% Unkown
HY-15648F GSK-J4 hydrochloride Inhibitor 99.01% Unkown
HY-15648 GSK-J1 Inhibitor 99.94% Unkown
HY-154812 Gintemetostat Inhibitor 99.81% Unkown
HY-W004588 tBu2bpy 99.39% Unkown
HY-162275 JMJD1C-IN-1 99.96% Unkown
HY-13808 UNC 0631 Inhibitor 99.27% Unkown
HY-152775 RK-701 Inhibitor 98.01% Unkown
HY-D0858C MES hydrate 99.90% Unkown
HY-157251 UNC8153 TFA Degrader 99.92% Unkown
HY-145103 UNC6934 Antagonist 98.24% Unkown
HY-D0858S MES-d13 99.93% Unkown
HY-13807 UNC0646 Inhibitor 99.38% Unkown
HY-D0858E MES potassium 99.88% Unkown
HY-15227A EPZ004777 hydrochloride 98.92% Unkown
HY-100360 MS049 Inhibitor 98.0% Unkown
HY-15648A GSK-J2 Control 99.75% Unkown
HY-66025 Fmoc-Lys(Me)2-OH hydrochloride 97.52% Unkown
HY-12033S2 2-Methoxyestradiol-d5 98.67% Unkown
HY-150510A MS8511 hydrochloride Inhibitor 98.07% Unkown
HY-161759 MS152 Inhibitor 99.36% Unkown
HY-162749A G9D-4 TFA 99.44% Unkown
HY-13808R UNC 0631 (Standard) Inhibitor 99.54% Unkown
HY-183058 EZM8266 Inhibitor 98.24% Unkown
HY-168992A UNC6535 TFA / Unkown
HY-156285 ZZM-1220 98.74% Unkown
HY-15648D GSK-J1 lithium salt Inhibitor 98.33% Unkown
HY-128579 DW14800 Inhibitor 99.12% Unkown
HY-150510 MS8511 Inhibitor / Unkown
HY-15313C CBB1007 trihydrochloride Inhibitor 97.08% Unkown
HY-157251A UNC8153 Degrader 99.61% Unkown
HY-161313 DYB-03 Inhibitor 99.49% Unkown
HY-164456 AMI-408 Inhibitor / Unkown
HY-D0858D MES hemisodium 98.0% Unkown
HY-116971 DCG066 99.78% Unkown
HY-120766 NCDM-32B Inhibitor 97.0% Unkown
HY-162749 G9D-4 / Unkown
HY-168992 UNC6535 Inhibitor / Unkown
HY-44062 G9a-IN-1 Inhibitor 98.12% Unkown
HY-P4895 (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin Antagonist 99.20% Unkown
HY-15313 CBB1007 Inhibitor / Unkown
HY-15313B CBB1007 hydrochloride Inhibitor 98.0% Unkown
HY-100360A MS049 dihydrochloride Inhibitor / Unkown
HY-168968S ZJY-54 Inhibitor / Unkown
HY-115619 EPZ004777 formate / Unkown
HY-12033S 2-Methoxyestradiol-13C,d3 / Unkown
HY-12033S1 2-Methoxyestradiol-13C6 / Unkown
HY-122595 EZH2-IN-1 Inhibitor / Unkown
HY-128931 NH2-Ph-C4-acid-NH2-Me / Unkown
HY-138604 5'-O-DMT-N6-Me-2'-dA Activator 98.00% Unkown
HY-148829 MS40 Degrader / Unkown
HY-154224 2’-O-Me-2-thio-U-3’-phos phoramidite / Unkown
HY-155817 UNC7096 Chemical / Unkown
HY-15648G GSK-J1 sodium Inhibitor / Unkown
HY-15648I GSK-J2 sodium Inhibitor / Unkown
HY-161787 G9a-IN-2 Inhibitor / Unkown
HY-168497 C-MS023 Inhibitor / Unkown
HY-173590 AW4 Inhibitor / Unkown
HY-175821 PRMT1-IN-3 / Unkown
HY-176283 Tubulin/LSD1-IN-1 / Unkown
HY-178378 G9a-IN-4 / Unkown
HY-179229 LSD1-IN-47 Inhibitor / Unkown
HY-179427 NSD2/H3K36me2 modulator-1 / Unkown
HY-179650 NSD2-PWWP1-IN-5 / Unkown
HY-179651 NSD2-PWWP1-IN-6 Inhibitor / Unkown
HY-180553 NSD2-IN-6 Inhibitor / Unkown
HY-183105 DC551040 / Unkown
HY-184500 TNG917 Inhibitor / Unkown
HY-P10819 S9-CMC1 TFA / Unkown
HY-P2014 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin Antagonist / Unkown
HY-P2253 H3K27(Me2) (15-34) / Unkown
HY-P4397 (d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin / Unkown
HY-RS02465 CELSR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08271 ME2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W657887 GSK-3β/G9a-IN-1 Inhibitor / Unkown
HY-134075 2-Amino-2'-O-methyladenosine / Unkown
HY-169217 CYP3A4-IN-4 Inhibitor / Unkown
HY-178568 DMTr-S-5-C-Me-2'-O-Me-rA(Bz)-3'-CE-phosphoramidite / Unkown
HY-178569 DMTr-S-5-C-Me-2'-O-Me-rC(Ac)-3'-CE-phosphoramidite / Unkown
HY-178643 DMTr-S-5-C-Me-2'-O-Me-rU-3'-CE-phosphoramidite / Unkown
HY-178660 DMTr-R-5'-C-Me-2'-O-Me-rA(Bz)-3'-CE-phosphoramidite / Unkown
HY-178663 DMTr-S-5-C-Me-2'-F-dA(Bz)-3'-CE-phosphoramidite / Unkown
HY-182110 5-Me-2'-Deoxyzebularine-CE phosphoramidite / Unkown
HY-D0858DR MES hemisodium (Standard) / Unkown
HY-P1162 (d(CH2)51,Tyr(Me)2,Arg8)-Vasopressin Antagonist / Unkown
HY-P5006 (d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin Antagonist / Unkown
HY-RS17416 Tcf4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17680 Me2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18501 Tcf3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24141 Me2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ME2 VGNC VGNC:97791
Felis catus ME2 VGNC VGNC:68226
Canis familiaris ME2 VGNC VGNC:43110
Rattus norvegicus ME2 RGD RGD:1310321
Mus musculus ME2 MGD MGI:2147351
Bos taurus ME2 VGNC VGNC:31340
Others ME2 NCBI