Gli1 - GLI family zinc finger 1 Gene

Also Known as Gli

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 140589

About Gli1

Primary_assembly 7: 63,156,926-63,169,251 reverse strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 201 orthologues, 14 paralogues and is associated with 27 phenotypes. Biased expression in Uterus (RPKM 36.2), Lung (RPKM 17.8) and 8 other tissues.

Summary

Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and microtubule binding activity. Involved in liver regeneration and prostate gland development. Predicted to be located in axoneme; cytosol; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Biomarker of ocular hypertension and pre-malignant neoplasm. Orthologous to human GLI1 (Gli family zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]

Gli1 Products (1)

mRNA Protein Name
NM_001191910.1 NP_001178839.1 zinc finger protein GLI1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in liver regeneration IEP
IEP: Inferred from expression pattern
22024090 RGD
involved in prostate gland development IEP
IEP: Inferred from expression pattern
15328011 RGD
involved in spermatid development IEP
IEP: Inferred from expression pattern
21893610 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Gli1 Protein Structure

COG5236

COG5236: cl28715 (195 - 432)

FOXP-CC

FOXP-CC: cl24666 (236 - 264)

ZF_C2H2

ZF_C2H2: sd00017 (302 - 324)

ZF_C2H2

ZF_C2H2: sd00017 (332 - 355)

ZF_C2H2

ZF_C2H2: sd00017 (363 - 384)

PHA03247

PHA03247: cl33720 (560 - 866)

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  • 1109 a.a.
Protein Preferred Names Protein Names

zinc finger protein GLI1

  • GLI-Kruppel family member GLI1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-13242 Taladegib Inhibitor 99.92% Phase 2

Pre-clinical Phase

Bioactive Molecules (31)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13901 GANT 61 99.80% Unkown
HY-P4860 Adropin (34-76) (human, mouse, rat) 98.23% Unkown
HY-W269593 Perfluorodecanoic acid Inhibitor 98.0% Unkown
HY-13282 GANT 58 Antagonist 99.37% Unkown
HY-N2112 Glaucocalyxin A 99.88% Unkown
HY-18366A RU-SKI 43 hydrochloride Inhibitor 98.81% Unkown
HY-122590 Glabrescione B Inhibitor 98.08% Unkown
HY-107551 Hh Pathway-IN-1 99.06% Unkown
HY-107408 SANT 2 Antagonist 99.41% Unkown
HY-W111144 T-1330 Inhibitor / Unkown
HY-18366 RU-SKI 43 Inhibitor / Unkown
HY-RS05472 GLI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-13242A Taladegib hydrochloride Inhibitor / Unkown
HY-137567 Prostaglandin E1 ethanolamide Activator / Unkown
HY-143400 HSP70-IN-3 Inhibitor / Unkown
HY-147670 TPB15 / Unkown
HY-159893 SMO-IN-5 / Unkown
HY-161459 GLI1-IN-1 / Unkown
HY-162273 Antibacterial agent 189 Inhibitor / Unkown
HY-176056 Hedgehog IN-9 / Unkown
HY-182641 SAG analog (cis-isomer) Activator / Unkown
HY-183335 SMO-IN-6 / Unkown
HY-N8270 Physalin H Inhibitor / Unkown
HY-N9684 Degalactotigonin / Unkown
HY-RS05473 Gli1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05474 Gli1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05480 GLIS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122017 Methoxy-SANT-2 Antagonist / Unkown
HY-13901R GANT 61 (Standard) / Unkown
HY-172449 GLI1-IN-3 Inhibitor / Unkown
HY-W338819 Clobetasol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gli1 NCBI NCBI:2735