Itk - IL2 inducible T cell kinase Gene

Also Known as Emt; Tsk; Tcsk

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16428

About Itk

Chromosome 11: 46,215,977-46,280,342 reverse strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 208 orthologues, 32 paralogues and is associated with 39 phenotypes. Biased expression in thymus adult (RPKM 35.8), spleen adult (RPKM 4.7) and 1 other tissue.

Summary

Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including T cell receptor signaling pathway; activation of Phospholipase C activity; and gamma-delta T cell activation. Acts upstream of or within NK T cell differentiation. Located in cell-cell junction and nucleus. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human Itk (IL2 inducible T cell kinase). [provided by Alliance of Genome Resources, Apr 2022]

Itk Products (5)

mRNA Protein Name
NM_010583.3 NP_034713.2 tyrosine-protein kinase ITK/TSK isoform 2
NM_001281965.1 NP_001268894.1 tyrosine-protein kinase ITK/TSK isoform 1
NM_001281968.1 NP_001268897.1 tyrosine-protein kinase ITK/TSK isoform 5
NM_001281966.1 NP_001268895.1 tyrosine-protein kinase ITK/TSK isoform 3
NM_001281967.1 NP_001268896.1 tyrosine-protein kinase ITK/TSK isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15662016 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within NK T cell differentiation IGI
IGI: Inferred from genetic interaction
18292523 MGI
acts upstream of or within NK T cell differentiation IMP
IMP: Inferred from mutant phenotype
18292523 MGI
involved in T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
10213685 MGI
involved in adaptive immune response IMP
IMP: Inferred from mutant phenotype
10213685 MGI
involved in gamma-delta T cell activation IMP
IMP: Inferred from mutant phenotype
23562159 MGI
acts upstream of or within interleukin-4 production IGI
IGI: Inferred from genetic interaction
18292523 MGI
acts upstream of or within interleukin-4 production IMP
IMP: Inferred from mutant phenotype
18292523 MGI
involved in positive regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
10213685 MGI
involved in protein phosphorylation IMP
IMP: Inferred from mutant phenotype
15662016 MGI
acts upstream of or within type II interferon production IGI
IGI: Inferred from genetic interaction
18292523 MGI
acts upstream of or within type II interferon production IMP
IMP: Inferred from mutant phenotype
18292523 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15662016 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Itk Protein Structure

PH_Btk

PH_Btk: cd01238 (6 - 147)

SH3_ITK

SH3_ITK: cd11908 (173 - 228)

SH2_Tec_Itk

SH2_Tec_Itk: cd10396 (231 - 338)

PTKc_Itk

PTKc_Itk: cd05112 (356 - 611)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 619 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase ITK/TSK

  • T-cell-specific kinase

  • interleukin-2-inducible T cell kinase

  • kinase TLK

Recombinant Itk Proteins

Cat. No. Product Name Accession Purity
HY-P74795 ITK Protein, Mouse (sf9, His-GST) Q03526 (R357-L625) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-150298 Soquelitinib Inhibitor 99.98% Phase 3
HY-109078 Vecabrutinib Inhibitor 99.76% Phase 2

Pre-clinical Phase

Bioactive Molecules (29)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-11092 BMS-509744 Inhibitor 98.05% Unkown
HY-12680 PRN694 Inhibitor ≥99.0% Unkown
HY-130665 TL12-186 Degrader 99.23% Unkown
HY-108691 PF-06465469 Inhibitor 99.48% Unkown
HY-148065 FMF-06-098-1 Inhibitor 98.77% Unkown
HY-101321A Immepip dihydrobromide Degrader 99.98% Unkown
HY-128726 ITK inhibitor 2 Inhibitor 99.50% Unkown
HY-12410 GNE-9822 Inhibitor 98.47% Unkown
HY-169396 TAE648 Ligand 99.50% Unkown
HY-120559 GSK-2250665A Inhibitor 96.35% Unkown
HY-185206 BSJ-05-037 Degrader 99.83% Unkown
HY-174280 Modzatinib Inhibitor / Unkown
HY-150023 BI-1622 Inhibitor 98.02% Unkown
HY-146672 ITK inhibitor 6 Inhibitor / Unkown
HY-13232 ITK antagonist Inhibitor / Unkown
HY-174903 ITK-IN-6 Inhibitor 99.02% Unkown
HY-149917 PROTAC ITK degrader 1 Degrader / Unkown
HY-N6857C (±)-Armepavine hydrochloride / Unkown
HY-16984 GNE-4997 Inhibitor / Unkown
HY-143901 EGFR-IN-40 Inhibitor / Unkown
HY-182335 PF-07245303 Inhibitor / Unkown
HY-168387 ITK ligand 1 Inhibitor / Unkown
HY-184275 ITK-IN-7 Inhibitor / Unkown
HY-168963 PROTAC BTK Degrader-13 Inhibitor / Unkown
HY-153322 ITK degrader 2 Degrader / Unkown
HY-141864 ITK/TRKA-IN-1 Inhibitor / Unkown
HY-189477 GNE-7056 Inhibitor / Unkown
HY-146671 ITK inhibitor 5 Inhibitor / Unkown
HY-E70833 ITK Recombinant Human Active Protein Kinase / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itk NCBI NCBI:3702