2. Gene
  3. Itk - IL2 inducible T cell kinase Gene

Itk - IL2 inducible T cell kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Emt; Tsk; Tcsk

Gene ID: 16428 | Gene type: protein coding

About Itk

Chromosome 11: 46,215,977-46,280,342 reverse strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 208 orthologues, 32 paralogues and is associated with 39 phenotypes. Biased expression in thymus adult (RPKM 35.8), spleen adult (RPKM 4.7) and 1 other tissue.

Summary

Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including T cell receptor signaling pathway; activation of Phospholipase C activity; and gamma-delta T cell activation. Acts upstream of or within NK T cell differentiation. Located in cell-cell junction and nucleus. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human Itk (IL2 inducible T cell kinase). [provided by Alliance of Genome Resources, Apr 2022]

Itk Products(5)

mRNA Protein Name
NM_010583.3 NP_034713.2 tyrosine-protein kinase ITK/TSK isoform 2
NM_001281965.1 NP_001268894.1 tyrosine-protein kinase ITK/TSK isoform 1
NM_001281968.1 NP_001268897.1 tyrosine-protein kinase ITK/TSK isoform 5
NM_001281966.1 NP_001268895.1 tyrosine-protein kinase ITK/TSK isoform 3
NM_001281967.1 NP_001268896.1 tyrosine-protein kinase ITK/TSK isoform 4

Itk Protein Structure

PH_Btk

PH_Btk: cd01238 (6 - 147)

SH3_ITK

SH3_ITK: cd11908 (173 - 228)

SH2_Tec_Itk

SH2_Tec_Itk: cd10396 (231 - 338)

PTKc_Itk

PTKc_Itk: cd05112 (356 - 611)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 619 a.a.
Protein Preferred Names Protein Names

tyrosine-protein kinase ITK/TSK

T-cell-specific kinase

interleukin-2-inducible T cell kinase

kinase TLK

Recombinant Itk Proteins

Cat. No. Product Name Accession Purity
HY-P74795 ITK Protein, Mouse (sf9, His-GST) Q03526 (R351-L619) ≥95%
HY-P74795A ITK Protein, Mouse (sf9, His-GST, Strep) Q03526 (R347-L625) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-109078 Vecabrutinib Inhibitor 99.85% Phase 2
Pre-clinical Phase
Bioactive Molecules (15)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-11092 BMS-509744 Inhibitor 98.09% Unkown
HY-12680 PRN694 Inhibitor 99.36% Unkown
HY-108691 PF-06465469 Inhibitor 99.48% Unkown
HY-150023 BI-1622 Inhibitor 98.97% Unkown
HY-128726 ITK inhibitor 2 Inhibitor 99.66% Unkown
HY-12410 GNE-9822 Inhibitor ≥95.0% Unkown
HY-150298 Soquelitinib Inhibitor / Unkown
HY-146672 ITK inhibitor 6 Inhibitor / Unkown
HY-146671 ITK inhibitor 5 Inhibitor / Unkown
HY-149917 ITK degrader 1 Degrader / Unkown
HY-141864 ITK/TRKA-IN-1 Inhibitor / Unkown
HY-120559 GSK-2250665A Inhibitor / Unkown
HY-153322 ITK degrader 2 Degrader / Unkown
HY-143901 EGFR-IN-40 Inhibitor / Unkown
HY-13232 ITK antagonist Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itk NCBI NCBI:3702