Lat - linker for activation of T cells Gene

Also Known as pp36; p36-38

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16797

Summary

Predicted to enable protein kinase binding activity and signaling receptor complex adaptor activity. Acts upstream of or within gene expression; inflammatory response; and lymphocyte homeostasis. Located in cell-cell junction and immunological synapse. Part of COP9 signalosome. Is expressed in liver and thymus primordium. Used to study IgG4-related disease. Human ortholog(s) of this gene implicated in immunodeficiency 52. Orthologous to human LAT (linker for activation of T cells). [provided by Alliance of Genome Resources, Apr 2022]

Lat Products (1)

mRNA Protein Name
NM_010689.3 NP_034819.1 linker for activation of T-cells family member 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21487392 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
16002666 MGI
acts upstream of or within homeostasis of number of cells IMP
IMP: Inferred from mutant phenotype
23793062 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
16002666 MGI
acts upstream of or within lymphocyte homeostasis IMP
IMP: Inferred from mutant phenotype
23776175 MGI
Cellular Component GO Annotation Evidence References Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
22561606 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
23793062 MGI
located in immunological synapse IDA
IDA: Inferred from direct assay
14635057 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

linker for activation of T-cells family member 1

  • 36 kDa phospho-tyrosine adapter protein

  • linker protein

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-14889 Fluciclovine / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-164401 QBS10072S Inducer / Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990610 KHK-2898 Inhibitor 97.16% Phase 1

Pre-clinical Phase

Bioactive Molecules (46)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138489 TRULI Inhibitor 99.98% Unkown
HY-150042 TDI-011536 Inhibitor 99.91% Unkown
HY-108540 BCH Inducer 99.83% Unkown
HY-160769 NIBR-LTSi 99.97% Unkown
HY-147082 GA-017 98.95% Unkown
HY-16929 Latrunculin A Inhibitor 98.9% Unkown
HY-W011391 GPNA hydrochloride 99.91% Unkown
HY-W087830 L-p-Boronophenylalanine 99.84% Unkown
HY-120139 KMH-233 Inhibitor 99.75% Unkown
HY-147165 VT02956 Inhibitor 99.58% Unkown
HY-139330 MGH-CP1 Inducer 99.56% Unkown
HY-N8847 α-Ionone 94.30% Unkown
HY-130504 Propargyl-PEG1-acid 97.0% Unkown
HY-155978A RDN2150 TFA Inhibitor 99.80% Unkown
HY-176886 LATS-IN-2 Inhibitor 99.45% Unkown
HY-164254 Cardiomyocyte proliferation promoting agent-1 Inhibitor 99.87% Unkown
HY-N3999 Venuloside A 99.82% Unkown
HY-175247 DDO-4033 99.11% Unkown
HY-W267524 H-Phe(3-CF3)-OH / Unkown
HY-120139A (R)-KMH-233 Control / Unkown
HY-183513 L-Ala-BPA Substrate / Unkown
HY-RS07538 LATS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-108540R BCH (Standard) Inducer 99.84% Unkown
HY-127042 6,7-Epoxy-latrunculin A Inhibitor / Unkown
HY-129934S Latanoprost ethyl amide-d4 / Unkown
HY-147165A VT02956 hydrochloride Inhibitor / Unkown
HY-164401A QBS10072S dihydrochloride / Unkown
HY-175649 LATS1/2-IN-1 Inhibitor / Unkown
HY-181743 Piezo1 agonist 2 Agonist / Unkown
HY-182254 AChE/BChE-IN-35 Inhibitor / Unkown
HY-183147A LAT1-IN-2 hydrochloride Substrate / Unkown
HY-RS07536 LAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07537 LAT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07539 LATS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09827 ORC3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13690 SPNS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-129934 Latanoprost ethyl amide / Unkown
HY-RS16816 Lat Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17343 Lats1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18181 Lats2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21361 Lat2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23256 Lat Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23797 Lats1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24655 Lats2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27880 Lat2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W246010 α,α-DiBn-DL-Gly Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lat NCBI NCBI:27040