Cdc25a - cell division cycle 25A Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 171102

Summary

Enables phosphoprotein Phosphatase activity. Involved in G1/S transition of mitotic cell cycle and positive regulation of cholangiocyte proliferation. Located in cytoplasm and nucleus. Used to study autosomal recessive polycystic kidney disease. Biomarker of autosomal recessive polycystic kidney disease. Human ortholog(s) of this gene implicated in cervical cancer; prostate cancer; and urinary bladder Cancer. Orthologous to human CDC25A (cell division cycle 25A). [provided by Alliance of Genome Resources, Apr 2022]

Cdc25a Products (1)

mRNA Protein Name
NM_133571.2 NP_598255.2 M-phase inducer phosphatase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables phosphoprotein phosphatase activity IDA
IDA: Inferred from direct assay
10373478 RGD
Biological Process GO Annotation Evidence References Source
involved in G1/S transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
8156993 RGD
involved in positive regulation of cholangiocyte proliferation IMP
IMP: Inferred from mutant phenotype
22155366 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

M-phase inducer phosphatase 1

  • dual specificity phosphatase Cdc25A

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-18174 Prexasertib 99.64% Phase 2
HY-18174A Prexasertib dihydrochloride 99.73% Phase 2
HY-18174E Prexasertib dimesylate 98.90% Phase 2
HY-18174B Prexasertib Mesylate Hydrate / Phase 2
HY-18174C Prexasertib mesylate / Phase 2

Pre-clinical Phase

Bioactive Molecules (22)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108543 NSC 95397 99.0% Unkown
HY-100034 NSC 663284 Inhibitor 99.29% Unkown
HY-132578 M5N36 Inhibitor 98.00% Unkown
HY-112776A BN82002 hydrochloride Inhibitor 99.36% Unkown
HY-121065 BN-82685 Inhibitor 99.05% Unkown
HY-128769 M2N12 Inhibitor 98.19% Unkown
HY-N7045 Isosilybin B 99.32% Unkown
HY-155816 PROTAC NSD3 degrader-1 99.40% Unkown
HY-W024644 Hydroxyethylthio Vitamine K3 ≥97.0% Unkown
HY-112776 BN82002 Inhibitor / Unkown
HY-118529 JUN-1111 Inhibitor 98.57% Unkown
HY-RS02291 CDC25A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-178295 VHR-IN-5 Inhibitor / Unkown
HY-178296 VHR-IN-6 Inhibitor / Unkown
HY-178297 VHR-IN-7 Inhibitor / Unkown
HY-178301 VHR-IN-9 Inhibitor / Unkown
HY-181011 PROTAC Cdc25 degrader-1 / Unkown
HY-28086 CDC25-IN-2 Inhibitor / Unkown
HY-P4979 Cdc25A (80-93) (human) / Unkown
HY-18174H Prexasertib lactate / Unkown
HY-RS17278 Cdc25a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23732 Cdc25a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cdc25a NCBI NCBI:993