Shh - sonic hedgehog Gene

Also Known as Hx; Dsh; Hhg1; Hxl3; ShhNC; M100081; 9530036O11Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 20423

Summary

Enables glycosaminoglycan binding activity; laminin-1 binding activity; and patched binding activity. Involved in several processes, including hematopoietic or lymphoid organ development; positive regulation of T cell activation; and regulation of smooth muscle cell differentiation. Acts upstream of or within several processes, including animal organ development; limb morphogenesis; and neurogenesis. Located in several cellular components, including cell surface; extracellular space; and membrane raft. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb bud; and sensory organ. Used to study brachydactyly type A1 and holoprosencephaly 3. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly. Orthologous to human SHH (sonic Hedgehog signaling molecule). [provided by Alliance of Genome Resources, Apr 2022]

Shh Products (1)

mRNA	Protein	Name
NM_009170.3	NP_033196.1	sonic hedgehog protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cholesterol-protein transferase activity	IDA IDA: Inferred from direct assay	8824192	MGI
enables glycosaminoglycan binding	IDA IDA: Inferred from direct assay	11476578	MGI
NOT enables hydrolase activity	IDA IDA: Inferred from direct assay	10500113	MGI
enables laminin-1 binding	IDA IDA: Inferred from direct assay	15056720	MGI
enables patched binding	IPI IPI: Inferred from physical interaction	9811851	MGI
enables peptidase activity	IDA IDA: Inferred from direct assay	8824192	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10500113	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within Bergmann glial cell differentiation	IDA IDA: Inferred from direct assay	10375501	MGI
involved in CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	IMP IMP: Inferred from mutant phenotype	17227833	MGI
acts upstream of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	10981962	MGI
involved in T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	19273836	MGI
acts upstream of T cell proliferation	IMP IMP: Inferred from mutant phenotype	10981962	MGI
acts upstream of alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	10981962	MGI
involved in alpha-tubulin acetylation	IDA IDA: Inferred from direct assay	27793670	MGI
acts upstream of or within anatomical structure development	IMP IMP: Inferred from mutant phenotype	11485934	MGI
acts upstream of or within anatomical structure formation involved in morphogenesis	IMP IMP: Inferred from mutant phenotype	9768363	MGI
acts upstream of or within androgen metabolic process	IMP IMP: Inferred from mutant phenotype	15013801	MGI
acts upstream of or within angiogenesis	IDA IDA: Inferred from direct assay	16778080	MGI
acts upstream of or within angiogenesis	IGI IGI: Inferred from genetic interaction	17187775	MGI
acts upstream of or within angiogenesis	IMP IMP: Inferred from mutant phenotype	17187775	MGI
acts upstream of or within animal organ formation	IMP IMP: Inferred from mutant phenotype	15013801	MGI
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	11118883	MGI
involved in apoptotic signaling pathway	IDA IDA: Inferred from direct assay	11044396	MGI
acts upstream of or within artery development	IGI IGI: Inferred from genetic interaction	16968815	MGI
acts upstream of or within artery development	IMP IMP: Inferred from mutant phenotype	16968815	MGI
acts upstream of astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	10357934	MGI
acts upstream of or within axon guidance	IDA IDA: Inferred from direct assay	12679031	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	12756179	MGI
acts upstream of or within blood coagulation	IMP IMP: Inferred from mutant phenotype	8835524	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	15936751	MGI
acts upstream of or within branching involved in prostate gland morphogenesis	IDA IDA: Inferred from direct assay	10208740	MGI
acts upstream of or within branching involved in salivary gland morphogenesis	IGI IGI: Inferred from genetic interaction	15042696	MGI
acts upstream of or within branching involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	15042696	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	16396903	MGI
acts upstream of or within branching morphogenesis of an epithelial tube	IMP IMP: Inferred from mutant phenotype	9768363	MGI
acts upstream of or within bud outgrowth involved in lung branching	IMP IMP: Inferred from mutant phenotype	9731532	MGI
acts upstream of or within camera-type eye development	IDA IDA: Inferred from direct assay	12195432	MGI
acts upstream of or within camera-type eye development	IGI IGI: Inferred from genetic interaction	18582859	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	12756179	MGI
acts upstream of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	17284610	MGI
acts upstream of or within cell development	IMP IMP: Inferred from mutant phenotype	15183722	MGI
acts upstream of or within cell fate commitment	IGI IGI: Inferred from genetic interaction	17504941	MGI
acts upstream of or within cell fate specification	IDA IDA: Inferred from direct assay	18076286	MGI
acts upstream of or within cell fate specification	IGI IGI: Inferred from genetic interaction	16647304	MGI
acts upstream of or within cell fate specification	IMP IMP: Inferred from mutant phenotype	12231626	MGI
acts upstream of cell migration	IDA IDA: Inferred from direct assay	15337776	MGI
acts upstream of cell population proliferation	IGI IGI: Inferred from genetic interaction	15496441	MGI
acts upstream of or within cell population proliferation	IGI IGI: Inferred from genetic interaction	19056373	MGI
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15183722	MGI
acts upstream of or within cell proliferation in external granule layer	IDA IDA: Inferred from direct assay	10970885	MGI
acts upstream of or within cell-cell signaling	IMP IMP: Inferred from mutant phenotype	15199404	MGI
acts upstream of or within cellular response to lithium ion	IDA IDA: Inferred from direct assay	17284610	MGI
acts upstream of or within central nervous system development	IMP IMP: Inferred from mutant phenotype	12435628	MGI
acts upstream of cerebellar granule cell precursor proliferation	IDA IDA: Inferred from direct assay	10027293	MGI
involved in cerebellar granule cell precursor proliferation	IDA IDA: Inferred from direct assay	22095825	MGI
involved in cerebellar granule cell precursor proliferation	IGI IGI: Inferred from genetic interaction	14687547	MGI
involved in determination of left/right asymmetry in lateral mesoderm	IMP IMP: Inferred from mutant phenotype	11517919	MGI
acts upstream of or within determination of left/right symmetry	IMP IMP: Inferred from mutant phenotype	10385121	MGI
acts upstream of or within developmental growth	IMP IMP: Inferred from mutant phenotype	11044393	MGI
acts upstream of or within digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	9731532	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IDA IDA: Inferred from direct assay	17442700	MGI
acts upstream of or within dorsal/ventral neural tube patterning	IGI IGI: Inferred from genetic interaction	17504941	MGI
involved in dorsal/ventral neural tube patterning	IMP IMP: Inferred from mutant phenotype	21209331	MGI
acts upstream of or within dorsal/ventral pattern formation	IGI IGI: Inferred from genetic interaction	21552265	MGI
acts upstream of or within ectoderm development	IMP IMP: Inferred from mutant phenotype	11118883	MGI
acts upstream of or within embryo development	IGI IGI: Inferred from genetic interaction	16020517	MGI
acts upstream of or within embryo development	IMP IMP: Inferred from mutant phenotype	17881493	MGI
acts upstream of or within embryonic digestive tract morphogenesis	IMP IMP: Inferred from mutant phenotype	10821773	MGI
acts upstream of or within embryonic digit morphogenesis	IGI IGI: Inferred from genetic interaction	15930098	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	20660756	MGI
involved in embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	11044396	MGI
acts upstream of or within embryonic foregut morphogenesis	IMP IMP: Inferred from mutant phenotype	9731532	MGI
acts upstream of or within embryonic forelimb morphogenesis	IMP IMP: Inferred from mutant phenotype	11118883	MGI
acts upstream of or within embryonic hindlimb morphogenesis	IMP IMP: Inferred from mutant phenotype	11118883	MGI
acts upstream of or within embryonic limb morphogenesis	IGI IGI: Inferred from genetic interaction	11389830	MGI
acts upstream of or within embryonic limb morphogenesis	IMP IMP: Inferred from mutant phenotype	15315763	MGI
acts upstream of or within embryonic morphogenesis	IMP IMP: Inferred from mutant phenotype	16492970	MGI
acts upstream of or within embryonic organ development	IMP IMP: Inferred from mutant phenotype	15680353	MGI
acts upstream of or within embryonic skeletal system development	IGI IGI: Inferred from genetic interaction	17504941	MGI
acts upstream of or within endocytosis	IDA IDA: Inferred from direct assay	18477453	MGI
acts upstream of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	16054035	MGI
acts upstream of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16054035	MGI
acts upstream of epithelial cell proliferation involved in prostate gland development	IMP IMP: Inferred from mutant phenotype	12221011	MGI
acts upstream of or within epithelial cell proliferation involved in salivary gland morphogenesis	IMP IMP: Inferred from mutant phenotype	15042696	MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis	IMP IMP: Inferred from mutant phenotype	9731532	MGI
acts upstream of or within epithelial-mesenchymal cell signaling	IMP IMP: Inferred from mutant phenotype	19304890	MGI
acts upstream of or within epithelial-mesenchymal signaling involved in prostate gland development	IGI IGI: Inferred from genetic interaction	15987773	MGI
acts upstream of or within establishment of epithelial cell polarity	IDA IDA: Inferred from direct assay	16332353	MGI
acts upstream of or within forebrain development	IGI IGI: Inferred from genetic interaction	16020517	MGI
acts upstream of or within forebrain regionalization	IMP IMP: Inferred from mutant phenotype	24528677	MGI
acts upstream of or within formation of anatomical boundary	IMP IMP: Inferred from mutant phenotype	9731532	MGI
acts upstream of or within gene expression	IDA IDA: Inferred from direct assay	23201751	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	23201751	MGI
involved in gene expression	IMP IMP: Inferred from mutant phenotype	21211521	MGI
acts upstream of or within hair follicle development	IMP IMP: Inferred from mutant phenotype	16054035	MGI
acts upstream of or within hair follicle morphogenesis	IMP IMP: Inferred from mutant phenotype	9768360	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	10500184	MGI
acts upstream of or within heart looping	IMP IMP: Inferred from mutant phenotype	10411502	MGI
involved in heart looping	IMP IMP: Inferred from mutant phenotype	11517919	MGI
acts upstream of or within hindbrain development	IGI IGI: Inferred from genetic interaction	15496441	MGI
acts upstream of or within hindbrain development	IMP IMP: Inferred from mutant phenotype	15183722	MGI
acts upstream of or within hindgut morphogenesis	IMP IMP: Inferred from mutant phenotype	11485934	MGI
acts upstream of or within inner ear development	IGI IGI: Inferred from genetic interaction	17395647	MGI
acts upstream of or within inner ear development	IMP IMP: Inferred from mutant phenotype	17395647	MGI
acts upstream of or within intermediate filament organization	IMP IMP: Inferred from mutant phenotype	11171399	MGI
acts upstream of or within kidney development	IMP IMP: Inferred from mutant phenotype	11172440	MGI
acts upstream of or within left lung development	IMP IMP: Inferred from mutant phenotype	10500184	MGI
acts upstream of or within limb bud formation	IMP IMP: Inferred from mutant phenotype	11118883	MGI
acts upstream of or within limb development	IGI IGI: Inferred from genetic interaction	19223390	MGI
acts upstream of or within limb development	IMP IMP: Inferred from mutant phenotype	19223390	MGI
acts upstream of or within lung development	IGI IGI: Inferred from genetic interaction	15136151	MGI
acts upstream of or within lung development	IMP IMP: Inferred from mutant phenotype	9731532	MGI
acts upstream of or within lung epithelium development	IMP IMP: Inferred from mutant phenotype	9731532	MGI
acts upstream of or within lung lobe morphogenesis	IMP IMP: Inferred from mutant phenotype	9731532	MGI
acts upstream of or within lung morphogenesis	IMP IMP: Inferred from mutant phenotype	10500184	MGI
acts upstream of or within lung-associated mesenchyme development	IMP IMP: Inferred from mutant phenotype	9731532	MGI
involved in lymphoid progenitor cell differentiation	IMP IMP: Inferred from mutant phenotype	14764698	MGI
acts upstream of or within male genitalia development	IMP IMP: Inferred from mutant phenotype	11684660	MGI
acts upstream of mesenchymal cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19422820	MGI
acts upstream of or within mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	9731532	MGI
acts upstream of or within mesenchymal cell proliferation involved in lung development	IDA IDA: Inferred from direct assay	9006067	MGI
acts upstream of or within mesenchymal smoothened signaling pathway involved in prostate gland development	IMP IMP: Inferred from mutant phenotype	12221011	MGI
involved in metanephric mesenchymal cell proliferation involved in metanephros development	IMP IMP: Inferred from mutant phenotype	12399320	MGI
involved in metanephros development	IMP IMP: Inferred from mutant phenotype	12399320	MGI
acts upstream of or within midbrain development	IGI IGI: Inferred from genetic interaction	16020517	MGI
acts upstream of or within myoblast differentiation	IDA IDA: Inferred from direct assay	15238161	MGI
acts upstream of or within myotube differentiation	IMP IMP: Inferred from mutant phenotype	11171399	MGI
acts upstream of or within negative regulation of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	10981962	MGI
acts upstream of or within negative regulation of T cell proliferation	IMP IMP: Inferred from mutant phenotype	10981962	MGI
acts upstream of or within negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	9356179	MGI
acts upstream of or within negative regulation of alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	10981962	MGI
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	11044396	MGI
acts upstream of or within negative regulation of apoptotic process	IGI IGI: Inferred from genetic interaction	19029980	MGI
acts upstream of or within negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	9731532	MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	17284610	MGI
acts upstream of or within negative regulation of cell migration	IDA IDA: Inferred from direct assay	15337776	MGI
involved in negative regulation of cholesterol efflux	IMP IMP: Inferred from mutant phenotype	21931618	MGI
involved in negative regulation of dopaminergic neuron differentiation	IMP IMP: Inferred from mutant phenotype	19122665	MGI
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16396903	MGI
involved in negative regulation of kidney smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	12399320	MGI
acts upstream of or within negative regulation of mesenchymal cell apoptotic process	IMP IMP: Inferred from mutant phenotype	19422820	MGI
acts upstream of or within negative regulation of neuron differentiation	IDA IDA: Inferred from direct assay	15337776	MGI
acts upstream of or within negative regulation of neuron differentiation	IMP IMP: Inferred from mutant phenotype	16236765	MGI
acts upstream of or within negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	16611981	MGI
acts upstream of or within negative regulation of protein binding	IDA IDA: Inferred from direct assay	35353806	MGI
acts upstream of or within negative regulation of protein catabolic process	IMP IMP: Inferred from mutant phenotype	16611981	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9769173	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	21447550	MGI
acts upstream of or within negative regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	17284610	MGI
involved in negative regulation of ureter smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	12399320	MGI
involved in negative thymic T cell selection	IMP IMP: Inferred from mutant phenotype	17227833	MGI
acts upstream of or within neural crest cell migration	IMP IMP: Inferred from mutant phenotype	15936751	MGI
acts upstream of neuroblast proliferation	IDA IDA: Inferred from direct assay	11748155	MGI
acts upstream of or within neuroblast proliferation	IDA IDA: Inferred from direct assay	15337776	MGI
acts upstream of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	16236765	MGI
acts upstream of neuron differentiation	IDA IDA: Inferred from direct assay	15337776	MGI
acts upstream of neuron differentiation	IMP IMP: Inferred from mutant phenotype	16236765	MGI
acts upstream of or within neuron fate commitment	IMP IMP: Inferred from mutant phenotype	16221724	MGI
acts upstream of or within odontogenesis	IDA IDA: Inferred from direct assay	10781055	MGI
acts upstream of or within odontogenesis of dentin-containing tooth	IMP IMP: Inferred from mutant phenotype	11044393	MGI
acts upstream of or within oligodendrocyte development	IDA IDA: Inferred from direct assay	8660874	MGI
acts upstream of or within oligodendrocyte differentiation	IGI IGI: Inferred from genetic interaction	11171336	MGI
acts upstream of or within osteoblast development	IDA IDA: Inferred from direct assay	16880529	MGI
acts upstream of or within pancreas development	IGI IGI: Inferred from genetic interaction	11044404	MGI
acts upstream of or within pancreas development	IMP IMP: Inferred from mutant phenotype	10821773	MGI
acts upstream of or within pattern specification process	IGI IGI: Inferred from genetic interaction	14602680	MGI
acts upstream of or within pattern specification process	IMP IMP: Inferred from mutant phenotype	12231626	MGI
involved in polarity specification of anterior/posterior axis	IMP IMP: Inferred from mutant phenotype	11044396	MGI
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9356179	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12399320	MGI
involved in positive regulation of T cell differentiation in thymus	IMP IMP: Inferred from mutant phenotype	19109233	MGI
acts upstream of or within positive regulation of Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	11520664	MGI
involved in positive regulation of alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	14764698	MGI
acts upstream of or within positive regulation of astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	10357934	MGI
acts upstream of or within positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11748155	MGI
acts upstream of or within positive regulation of cell population proliferation	IGI IGI: Inferred from genetic interaction	15496441	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15183722	MGI
acts upstream of or within positive regulation of cerebellar granule cell precursor proliferation	IDA IDA: Inferred from direct assay	10027293	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IGI IGI: Inferred from genetic interaction	16054035	MGI
acts upstream of or within positive regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	16054035	MGI
acts upstream of or within positive regulation of epithelial cell proliferation involved in prostate gland development	IMP IMP: Inferred from mutant phenotype	12221011	MGI
acts upstream of or within positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	11118883	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	16396903	MGI
involved in positive regulation of immature T cell proliferation in thymus	IMP IMP: Inferred from mutant phenotype	14764698	MGI
involved in positive regulation of kidney smooth muscle cell differentiation	IDA IDA: Inferred from direct assay	12399320	MGI
acts upstream of or within positive regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	9731532	MGI
involved in positive regulation of mesenchymal cell proliferation involved in ureter development	IMP IMP: Inferred from mutant phenotype	12399320	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IDA IDA: Inferred from direct assay	11748155	MGI
acts upstream of or within positive regulation of neuroblast proliferation	IMP IMP: Inferred from mutant phenotype	16236765	MGI
acts upstream of or within positive regulation of oligodendrocyte differentiation	IDA IDA: Inferred from direct assay	11171336	MGI
acts upstream of or within positive regulation of protein import into nucleus	IGI IGI: Inferred from genetic interaction	17043310	MGI
acts upstream of or within positive regulation of skeletal muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	11171399	MGI
acts upstream of or within positive regulation of skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	11171399	MGI
acts upstream of or within positive regulation of striated muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	11171399	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9006067	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21447550	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9585504	MGI
acts upstream of positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	11517919	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9731532	MGI
involved in positive regulation of ureter smooth muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	12399320	MGI
involved in positive thymic T cell selection	IMP IMP: Inferred from mutant phenotype	17227833	MGI
acts upstream of or within primary prostatic bud elongation	IDA IDA: Inferred from direct assay	10208740	MGI
acts upstream of or within prostate epithelial cord elongation	IDA IDA: Inferred from direct assay	15013801	MGI
acts upstream of or within prostate gland development	IMP IMP: Inferred from mutant phenotype	10208740	MGI
NOT acts upstream of or within prostatic bud formation	IGI IGI: Inferred from genetic interaction	15013801	MGI
acts upstream of protein import into nucleus	IGI IGI: Inferred from genetic interaction	17043310	MGI
acts upstream of or within protein localization to nucleus	IDA IDA: Inferred from direct assay	19952108	MGI
acts upstream of or within regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	11171399	MGI
acts upstream of or within regulation of epithelial cell proliferation involved in prostate gland development	IMP IMP: Inferred from mutant phenotype	12221011	MGI
acts upstream of or within regulation of gene expression	IDA IDA: Inferred from direct assay	22179047	MGI
acts upstream of or within regulation of gene expression	IGI IGI: Inferred from genetic interaction	18799682	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	11476582	MGI
acts upstream of or within regulation of glial cell proliferation	IDA IDA: Inferred from direct assay	12756179	MGI
acts upstream of or within regulation of mesenchymal cell proliferation involved in prostate gland development	IMP IMP: Inferred from mutant phenotype	12221011	MGI
involved in regulation of odontogenesis	IMP IMP: Inferred from mutant phenotype	21447550	MGI
acts upstream of or within regulation of prostatic bud formation	IDA IDA: Inferred from direct assay	18393306	MGI
acts upstream of or within regulation of prostatic bud formation	IMP IMP: Inferred from mutant phenotype	12221011	MGI
acts upstream of or within regulation of proteolysis	IDA IDA: Inferred from direct assay	15136151	MGI
acts upstream of or within regulation of stem cell proliferation	IMP IMP: Inferred from mutant phenotype	12221011	MGI
acts upstream of or within respiratory tube development	IMP IMP: Inferred from mutant phenotype	9731532	MGI
acts upstream of or within right lung development	IMP IMP: Inferred from mutant phenotype	10500184	MGI
acts upstream of or within roof of mouth development	IMP IMP: Inferred from mutant phenotype	19304890	MGI
acts upstream of or within salivary gland cavitation	IDA IDA: Inferred from direct assay	16332353	MGI
involved in self proteolysis	IDA IDA: Inferred from direct assay	8824192	MGI
acts upstream of skeletal muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	11171399	MGI
acts upstream of or within skeletal muscle fiber differentiation	IMP IMP: Inferred from mutant phenotype	15238161	MGI
acts upstream of skeletal muscle tissue development	IMP IMP: Inferred from mutant phenotype	11171399	MGI
acts upstream of or within skin development	IMP IMP: Inferred from mutant phenotype	10331973	MGI
acts upstream of or within smoothened signaling pathway	IDA IDA: Inferred from direct assay	8906787	MGI
acts upstream of or within smoothened signaling pathway	IGI IGI: Inferred from genetic interaction	16880529	MGI
acts upstream of or within smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	10340755	MGI
involved in smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	11517919	MGI
involved in somite development	IMP IMP: Inferred from mutant phenotype	11517919	MGI
acts upstream of or within spinal cord dorsal/ventral patterning	IMP IMP: Inferred from mutant phenotype	11748151	MGI
acts upstream of or within spinal cord motor neuron differentiation	IGI IGI: Inferred from genetic interaction	21552265	MGI
involved in stem cell development	IMP IMP: Inferred from mutant phenotype	12843296	MGI
acts upstream of or within stem cell proliferation	IDA IDA: Inferred from direct assay	15337776	MGI
acts upstream of or within striated muscle cell differentiation	IDA IDA: Inferred from direct assay	15238161	MGI
acts upstream of or within striated muscle tissue development	IMP IMP: Inferred from mutant phenotype	11171399	MGI
acts upstream of or within telencephalon regionalization	IMP IMP: Inferred from mutant phenotype	11060228	MGI
acts upstream of or within thalamus development	IGI IGI: Inferred from genetic interaction	19357274	MGI
acts upstream of or within thalamus development	IMP IMP: Inferred from mutant phenotype	19357274	MGI
involved in thymus development	IMP IMP: Inferred from mutant phenotype	19109233	MGI
acts upstream of or within thyroid gland development	IMP IMP: Inferred from mutant phenotype	16968815	MGI
acts upstream of or within trachea development	IMP IMP: Inferred from mutant phenotype	9731532	MGI
acts upstream of or within trachea morphogenesis	IMP IMP: Inferred from mutant phenotype	9731532	MGI
acts upstream of or within tracheoesophageal septum formation	IMP IMP: Inferred from mutant phenotype	9731532	MGI
acts upstream of trunk neural crest cell migration	IDA IDA: Inferred from direct assay	15337776	MGI
acts upstream of or within vasculature development	IMP IMP: Inferred from mutant phenotype	17881493	MGI
acts upstream of or within vasculogenesis	IDA IDA: Inferred from direct assay	15294868	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	15576403	MGI
located in extracellular matrix	IDA IDA: Inferred from direct assay	11476578	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	7891723	MGI
located in membrane	IDA IDA: Inferred from direct assay	18477453	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	15075292	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sonic hedgehog protein	HHG-1 hemimelic extra toes shh unprocessed N-terminal signaling and C-terminal autoprocessing domains short digits

Recombinant Shh Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7288	SHH Protein, Mouse (CHO)	Q62226 (C25-G198)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7290	SHH Protein, Mouse	Q62226 (C25-G198, C25I-V-I)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7409	SHH Protein, Mouse (C25II)	Q62226 (C25-G198, C25II)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73418	SHH Protein, Mouse (HEK293, His)	Q62226 (C25-G198)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P701100	SHH Protein, Mouse (HEK293)	Q62226 (C25-G198)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0508	Ornidazole	Inhibitor	99.49%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13242	Taladegib	Inhibitor	99.92%	Phase 2

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100224	SANT-1		99.87%	Unkown
HY-100515	Robotnikinin	Inhibitor	98.98%	Unkown
HY-N0836	Jervine		99.28%	Unkown
HY-108439	Neurodazine	Activator	99.0%	Unkown
HY-158059	DS-1-38	Inhibitor	99.57%	Unkown
HY-P10875	HL2-m5	Inhibitor	98.06%	Unkown
HY-144881	(S)-HH2853	Inhibitor	/	Unkown
HY-123781A	RUSKI-201 dihydrochloride	Inhibitor	98.20%	Unkown
HY-145387	MRT-81	Antagonist	99.85%	Unkown
HY-116455	BRD-9526		/	Unkown
HY-13242A	Taladegib hydrochloride	Inhibitor	/	Unkown
HY-147743	SMO-IN-1	Inhibitor	/	Unkown
HY-147744	AZD7254	Inhibitor	/	Unkown
HY-183335	SMO-IN-6		/	Unkown
HY-B0508S	Ornidazole-d5	Inhibitor	/	Unkown
HY-B0508S1	Ornidazole-13C2,15N2	Inhibitor	/	Unkown
HY-RS12865	SHH Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-120664	BRD50837	Inhibitor	/	Unkown
HY-123781	RUSKI-201	Inhibitor	/	Unkown
HY-164500	MC3629	Inhibitor	/	Unkown
HY-N0836A	Jervine hydriodide		/	Unkown
HY-N18954	Heparin disaccharide III-S trisodium	Inhibitor	/	Unkown
HY-RS16599	Shh Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23033	Shh Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W338819	Clobetasol		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992409	MEDI-5304	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Shh	NCBI	NCBI:6469