ERG - ETS transcription factor ERG Gene

Also Known as p55; erg-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2078

About ERG

Cytogenetic location: 21q22.2 Genomic coordinates (GRCh38): 21:38,367,261-38,661,783 (from NCBI)

This gene has 15 transcripts (splice variants), 160 orthologues, 28 paralogues and is associated with 120 phenotypes. Broad expression in fat (RPKM 7.8), spleen (RPKM 6.9) and 23 other tissues.

Summary

This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and Apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate Cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]

ERG Products (9)

mRNA	Protein	Name
NM_001136154.1	NP_001129626.1	transcriptional regulator ERG isoform 3
NM_001136155.1	NP_001129627.1	transcriptional regulator ERG isoform 4
NM_001243428.1	NP_001230357.1	transcriptional regulator ERG isoform 3
NM_001243429.1	NP_001230358.1	transcriptional regulator ERG isoform 5
NM_001243432.2	NP_001230361.1	transcriptional regulator ERG isoform 6
NM_001291391.1	NP_001278320.1	transcriptional regulator ERG isoform 7
NM_001331025.2	NP_001317954.1	transcriptional regulator ERG isoform 8
NM_004449.4	NP_004440.1	transcriptional regulator ERG isoform 2
NM_182918.4	NP_891548.1	transcriptional regulator ERG isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	18195090	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23093599	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20478527	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18195090	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18195090	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of ribonucleoprotein complex	IDA IDA: Inferred from direct assay	17289661	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERG Protein Structure

SAM_PNT

Ets

0
100
200
300
400
479 a.a.

Protein Preferred Names	Protein Names
transcriptional regulator ERG	ERG, ETS transcription factor

ERG Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ERG	P11308	PARP1	Homo sapiens	P09874	Anti Bait CoIP	21575865
Intra	ERG	P11308	AR	Homo sapiens	P10275	Anti Bait CoIP	20478527
Intra	ERG	P11308	KDM4A	Homo sapiens	O75164	Anti Tag CoIP	27109047
Intra	ERG	P11308	KDM4A	Homo sapiens	O75164	Pull Down	27109047

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ERG Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71733	ERG Protein, Human (P.pastoris, His)	P11308-3 (M1-Y486)	≥ 95%, as determined by reducing SDS-PAGE.

ERG Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83097	ERG Antibody (YA2842)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P83097A	ERG Antibody (YA2842)(PBS only)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P85855	ERG Antibody (YA5547)	WB, ICC/IF, ELISA	Human
HY-P86237	ERG Antibody (YA5929)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Neurofibromatosis-Noonan Syndrome	NFNS Neurofibromatosis Type 1 Neurofibromatosis With Noonan Phenotype Nf1 Von Recklinghausen Disease Neurofibromatosis Type 1-Noonan Syndrome Noonan Neurofibromatosis Syndrome Recklinghausen'S Disease Noonan-Neurofibromatosis Syndrome Fibromatosis Multiple Non Ossifying Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots Jaffe Campanacci Syndrome Type 1 Neurofibromatosis Neurofibromatosis 1 Peripheral Neurofibromatosis Recklinghausen Disease, Nerve Jaffe-Campanacci Syndrome
Neurofibromatosis, Type I	Von Recklinghausen Disease Neurofibromatosis 1 Neurofibromatosis, Type 1 NF1 Neurofibromatosis, Peripheral Type Neurofibromatosis Type I Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion Familial Spinal Neurofibromatosis Fsnf Peripheral Neurofibromatosis Von Recklinghausen'S Neurofibromatosis Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion Neurofibromatosis Peripheral Type Von Recklinghausen Syndrome Neurofibromatosis Type 1 Von Recklinghausen Neuropathy Nf1 - [Neurofibromatosis Type 1] Recklinghausen Disease
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Myxoid Liposarcoma	Myxoid/Round Cell Liposarcoma Liposarcoma, Myxoid Mrcls Myxoliposarcoma MXLIPO Liposarcoma Myxoid Liposarcoma
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Long Qt Syndrome	Romano-Ward Syndrome Long Q-T Syndrome Lqt Qt Syndrome, Long Congenital Long Qt Syndrome Familial Long Qt Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0148A	Halofantrine hydrochloride	Inhibitor	99.90%	Yes
HY-A0148	Halofantrine	Inhibitor	/	Unkown
HY-A0148AR	Halofantrine hydrochloride (Standard)	Inhibitor	/	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-Y0282	Sodium bromide		99.2%	Phase 3

Pre-clinical Phase

Bioactive Molecules (34)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W193545A	ERG240	Inhibitor	98.0%	Unkown
HY-162351	EBP-IN-1	Inhibitor	99.77%	Unkown
HY-159730	ERG245	Inhibitor	99.49%	Unkown
HY-122234	VPC-18005	Inhibitor	99.80%	Unkown
HY-N7848	Linoleamide	Inhibitor	99.4%	Unkown
HY-112158	NSC139021		99.77%	Unkown
HY-16915	RPR-260243	Activator	99.37%	Unkown
HY-121964	cis-Piperidine-2,3-dicarboxylic acid	Agonist	95.0%	Unkown
HY-139893	ERGi-USU-6 mesylate	Inhibitor	95.0%	Unkown
HY-108592	UCL 2077	Inhibitor	98.91%	Unkown
HY-116445	UNC9975	Agonist	/	Unkown
HY-117744	NMS-P645	Inhibitor	/	Unkown
HY-124057	RO5126946	Activator	/	Unkown
HY-144694	HDAC/HSP90-IN-3	Inhibitor	/	Unkown
HY-145814	HSP90-IN-9	Inhibitor	/	Unkown
HY-159585	CYP51-IN-20	Inhibitor	/	Unkown
HY-175663	EYE-002	Inhibitor	/	Unkown
HY-175664	EYE-003	Inhibitor	/	Unkown
HY-180918	ERG-IN-4		/	Unkown
HY-180919	ERG-IN-5	Inhibitor	/	Unkown
HY-181103	ERG-IN-6		/	Unkown
HY-183202	NCD38		/	Unkown
HY-184190	ERG-IN-7	Inhibitor	/	Unkown
HY-P1426	AmmTX3	Inhibitor	/	Unkown
HY-P5806	Ergtoxin-1	Antagonist	/	Unkown
HY-RS04491	ERG Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04492	ERG28 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04493	ERGIC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04494	ERGIC3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W749520	Zymosterone		/	Unkown
HY-117523	(Z)-RG-13022	Inhibitor	/	Unkown
HY-184314	Antifungal agent-166	Inhibitor	/	Unkown
HY-RS16711	Erg Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23146	Erg Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991886	ANX-M1 (Human IgG1)	Inhibitor	≥99.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ERG	VGNC	VGNC:50174
Canis familiaris	ERG	VGNC	VGNC:40448
Felis catus	ERG	VGNC	VGNC:61937
Rattus norvegicus	ERG	RGD	RGD:621108
Mus musculus	ERG	MGD	MGI:95415
Macaca mulatta	ERG	VGNC	VGNC:72427
Others	ERG	NCBI