Mchr1 - melanin-concentrating hormone receptor 1 Gene

Also Known as Gpr24; Mch1r

Species: Mus musculus

Gene Type: protein coding
Gene ID: 207911

About Mchr1

Chromosome 15: 81,119,700-81,123,165 forward strand.GRCm39:CM001008.3

This gene has 1 transcript (splice variant), 241 orthologues, 55 paralogues and is associated with 35 phenotypes. Broad expression in cortex adult (RPKM 5.3), frontal lobe adult (RPKM 4.6) and 19 other tissues.

Summary

Enables signaling receptor binding activity. Predicted to be involved in several processes, including neuropeptide signaling pathway; positive regulation of calcium ion transport; and positive regulation of cytosolic calcium ion concentration. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in ciliary membrane and non-motile cilium. Is expressed in brain and lung. Human ortholog(s) of this gene implicated in morbid obesity. Orthologous to human MCHR1 (melanin concentrating hormone receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Mchr1 Products (1)

mRNA Protein Name
NM_145132.2 NP_660114.1 melanin-concentrating hormone receptor 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
35311242 MGI
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
23029470 MGI
Cellular Component GO Annotation Evidence References Source
located in ciliary membrane IDA
IDA: Inferred from direct assay
22139371 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
23029470 MGI
located in non-motile cilium IDA
IDA: Inferred from direct assay
18334641 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
15950311 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Mchr1 Protein Structure

7tmA_MCHR1

7tmA_MCHR1: cd15338 (40 - 321)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (41 - 67)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (77 - 103)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (115 - 145)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (157 - 177)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (204 - 233)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (248 - 278)

7tmA_MCHR1

7tmA_MCHR1: cd15338 (289 - 314)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
Protein Preferred Names Protein Names

melanin-concentrating hormone receptor 1

  • G protein coupled receptor 24

  • Gpr24-9 protein coupled receptor

  • MCH receptor 1

  • MCHR

  • SLC-1

  • somatostatin receptor-like protein

Mchr1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Mchr1 Q8JZL2 Mrap2 Mus musculus D3Z1Q2
Anti Tag CoIP
35311242
Intra
Mchr1 Q8JZL2 Mrap2 Mus musculus D3Z1Q2
Confocal
35311242
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-U00257 AZD1979 Antagonist 99.59% Phase 1
HY-100318 MCHR1 antagonist 5 Antagonist 99.61% Phase 1
HY-12433A BMS-830216 Antagonist / Phase 1

Pre-clinical Phase

Bioactive Molecules (23)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1205A MCH(human, mouse, rat) TFA Ligand 99.09% Unkown
HY-107625A SNAP 94847 hydrochloride Inhibitor 99.90% Unkown
HY-100321 MCHR1 antagonist 2 98.27% Unkown
HY-108049 GW856464 Antagonist 99.83% Unkown
HY-12433 BMS-819881 99.78% Unkown
HY-P1204 [Ala17]-MCH Agonist 98.28% Unkown
HY-RS08225 MCHR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-107626 ATC0065 Antagonist 99.09% Unkown
HY-101699 AMG-076 free base Antagonist / Unkown
HY-107625 SNAP 94847 Antagonist / Unkown
HY-107626A ATC0065 free base Antagonist / Unkown
HY-116031 ATC0175 free base Antagonist / Unkown
HY-119015 MCHR1 antagonist 6 Antagonist / Unkown
HY-120608 BMS-814580 Inhibitor / Unkown
HY-120847 BI 186908 Antagonist / Unkown
HY-136152 MCHR1 antagonist 3 Antagonist / Unkown
HY-161899 MCHR1 antagonist 4 Antagonist / Unkown
HY-185478 NGD-4715 Antagonist / Unkown
HY-P1204A [Ala17]-MCH TFA Agonist / Unkown
HY-RS08226 Mchr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08227 Mchr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-101699A AMG-076 Antagonist / Unkown
HY-U00353 MCHR1 antagonist 1 Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mchr1 NCBI NCBI:2847