Wrn - Werner syndrome RecQ like helicase Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22427

Summary

Enables 3'-5' exonuclease activity. Involved in G-quadruplex DNA unwinding. Acts upstream of or within several processes, including multicellular organism aging; regulation of growth rate; and replicative senescence. Located in chromosome, telomeric region; nucleoplasm; and replication fork. Is expressed in coelomic epithelium of testis; metanephros; and spleen. Used to study Werner syndrome. Human ortholog(s) of this gene implicated in Werner syndrome; breast cancer; coronary artery disease (multiple); diffuse scleroderma; and senile cataract. Orthologous to human WRN (WRN RecQ like helicase). [provided by Alliance of Genome Resources, Apr 2022]

Wrn Products (2)

mRNA Protein Name
NM_001122822.1 NP_001116294.1 bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
NM_011721.4 NP_035851.3 bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3'-5' exonuclease activity IDA
IDA: Inferred from direct assay
10871373 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11301316 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within DNA metabolic process IMP
IMP: Inferred from mutant phenotype
11756244 MGI
involved in DNA replication IGI
IGI: Inferred from genetic interaction
26195664 MGI
acts upstream of or within DNA replication IMP
IMP: Inferred from mutant phenotype
9789047 MGI
involved in DNA replication IMP
IMP: Inferred from mutant phenotype
26195664 MGI
involved in G-quadruplex DNA unwinding IGI
IGI: Inferred from genetic interaction
26195664 MGI
involved in G-quadruplex DNA unwinding IMP
IMP: Inferred from mutant phenotype
26195664 MGI
acts upstream of or within determination of adult lifespan IGI
IGI: Inferred from genetic interaction
15235603 MGI
acts upstream of or within regulation of growth rate IMP
IMP: Inferred from mutant phenotype
12707040 MGI
acts upstream of or within replicative senescence IMP
IMP: Inferred from mutant phenotype
10757812 MGI
acts upstream of or within telomere maintenance IGI
IGI: Inferred from genetic interaction
15235603 MGI
acts upstream of or within telomere maintenance IMP
IMP: Inferred from mutant phenotype
12707040 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome, telomeric region IMP
IMP: Inferred from mutant phenotype
26195664 MGI
NOT located in nucleolus IDA
IDA: Inferred from direct assay
11420665 MGI
located in nucleoplasm IDA
IDA: Inferred from direct assay
11420665 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9789047 MGI
located in replication fork IMP
IMP: Inferred from mutant phenotype
26195664 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

Werner syndrome ATP-dependent helicase homolog

  • Werner syndrome homolog

  • Werner syndrome protein homolog

  • exonuclease WRN

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-169422 GSK4418959 Inhibitor 99.07% Phase 2
HY-148699 HRO761 Inhibitor 99.58% Phase 1
HY-158116 VVD-214 Inhibitor 99.99% Phase 1

Pre-clinical Phase

Bioactive Molecules (46)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12342 ML216 Inhibitor 99.89% Unkown
HY-110185 NSC 617145 Inhibitor 99.53% Unkown
HY-162471 GSK_WRN3 Inhibitor 98.10% Unkown
HY-163942 GSK_WRN4 Inhibitor 98.85% Unkown
HY-156579 WRN inhibitor 3 Inhibitor 99.54% Unkown
HY-156581 WRN inhibitor 5 Inhibitor 98.12% Unkown
HY-160859 WRN inhibitor 8 Inhibitor 98.07% Unkown
HY-148740 Werner syndrome RecQ helicase-IN-3 Inhibitor 99.94% Unkown
HY-149887 H3B-968 98.22% Unkown
HY-148741 Werner syndrome RecQ helicase-IN-4 Inhibitor 98.13% Unkown
HY-128712 NCGC00029283 Inhibitor 98.88% Unkown
HY-156580 WRN inhibitor 4 Inhibitor 99.40% Unkown
HY-163941 GSK_WRN2 95.95% Unkown
HY-153692 WRN inhibitor 1 Inhibitor 98.05% Unkown
HY-153973 WRN inhibitor 2 99.60% Unkown
HY-175750 MOMA-341 Inhibitor / Unkown
HY-148700 Werner syndrome RecQ helicase-IN-2 Inhibitor 99.32% Unkown
HY-169422A GSK4418959 (enantiomer) 95.0% Unkown
HY-158025 Anticancer agent 198 Inhibitor / Unkown
HY-153692A (R)-WRN inhibitor 1 / Unkown
HY-157954 WRN inhibitor 6 / Unkown
HY-161386 WRN inhibitor 7 / Unkown
HY-163797 WRN inhibitor 10 Inhibitor / Unkown
HY-164852 WRN inhibitor 13 / Unkown
HY-168583 WRN inhibitor 11 Inhibitor / Unkown
HY-168592 WRN inhibitor 12 Inhibitor / Unkown
HY-168933 KWR095 Inhibitor / Unkown
HY-168934 KWR137 Inhibitor / Unkown
HY-169414 WRN inhibitor 15 / Unkown
HY-169423 WRN inhibitor 17 Inhibitor / Unkown
HY-169424 WRN inhibitor 18 Inhibitor / Unkown
HY-169928 WRN inhibitor 14 Inhibitor / Unkown
HY-174217 WRN-IN-19 Inhibitor / Unkown
HY-176727 WRN inhibitor 19 Inhibitor / Unkown
HY-176912 WRN-IN-22 Inhibitor / Unkown
HY-178474 WRN-IN-20 / Unkown
HY-178991 WRN-IN-21 Inhibitor / Unkown
HY-179326 WRN-IN-23 / Unkown
HY-181562 WRN-IN-24 Inhibitor / Unkown
HY-182313 WRN-IN-25 Inhibitor / Unkown
HY-182634 NCGC00063279 Inhibitor / Unkown
HY-183610 WRN-IN-26 / Unkown
HY-184427 WRN-IN-27 Inhibitor / Unkown
HY-RS15847 WRN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16538 Wrn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22970 Wrn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wrn NCBI NCBI:7486