Ikzf3 - IKAROS family zinc finger 3 Gene

Also Known as Aiolos; Zfpn1a3; Znfn1a3; 5830411O07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22780

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of B cell differentiation; and regulation of B cell proliferation. Acts upstream of or within response to bacterium. Located in cytoplasm and nucleus. Is expressed in Peyer's patch; genitourinary system; immune system; lung; and spinal cord. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IKZF3 (IKAROS family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]

Ikzf3 Products (1)

mRNA Protein Name
NM_011771.1 NP_035901.1 zinc finger protein Aiolos

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
9155026 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: Inferred from mutant phenotype
34155405 MGI
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9155026 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9155026 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
9155026 MGI
Biological Process GO Annotation Evidence References Source
involved in B cell differentiation IMP
IMP: Inferred from mutant phenotype
34155405 MGI
involved in T cell differentiation IMP
IMP: Inferred from mutant phenotype
34155405 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9155026 MGI
involved in regulation of B cell differentiation IMP
IMP: Inferred from mutant phenotype
9806640 MGI
involved in regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
9806640 MGI
involved in regulation of lymphocyte differentiation IMP
IMP: Inferred from mutant phenotype
9155026 MGI
acts upstream of or within response to bacterium IEP
IEP: Inferred from expression pattern
23012479 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
9155026 MGI
located in nucleus IDA
IDA: Inferred from direct assay
9155026 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

zinc finger protein Aiolos

  • ikaros family zinc finger protein 3

  • zinc finger protein, subfamily 1A, 3 (Aiolos)

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10984 Pomalidomide Degrader 99.96% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-144841 Cemsidomide Degrader 99.54% Phase 2

Pre-clinical Phase

Bioactive Molecules (20)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W1135319 SB-405483 99.33% Unkown
HY-144995 BSJ-02-162 Degrader 98.07% Unkown
HY-161101 MG degrader 1 Degrader 99.30% Unkown
HY-153220A (R)-Zelebrudomide Degrader 98.93% Unkown
HY-168615 MGD-28 Degrader 99.73% Unkown
HY-168614 MGD-4 Degrader / Unkown
HY-169077 IKZF3 degrader 1 Degrader / Unkown
HY-172368 PROTAC IKZF3 degrader-1 Degrader / Unkown
HY-181651 SZU305 Inhibitor / Unkown
HY-179077 PROTAC BTK/IKZF1/3 Degrader-1 Degrader / Unkown
HY-179075 PROTAC BCL6/IKZF1/3 Degrader-1 Degrader / Unkown
HY-175040 PROTAC FLT-3 degrader 5 Degrader / Unkown
HY-180836 DIX-01 Degrader / Unkown
HY-184967 XZ8078 Degrader / Unkown
HY-182797 NHWL071065 Degrader / Unkown
HY-168586 PROTAC IRAK4 degrader-12 Degrader / Unkown
HY-175600 MI-2-80 Degrader / Unkown
HY-175602 TM-04-064-02 Degrader / Unkown
HY-179076 BTK/IKZF1/3 ligand 1 Ligand / Unkown
HY-175502 MGD-22 Degrader / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ikzf3 NCBI NCBI:22806