Cxcl10 - C-X-C motif chemokine ligand 10 Gene

Also Known as IP-10; Scyb10

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 245920

Summary

Enables chemokine activity. Involved in several processes, including response to auditory stimulus; response to gamma radiation; and response to vitamin D. Located in extracellular space. Used to study adult respiratory distress syndrome; myocarditis; proteinuria; renovascular hypertension; and type 1 diabetes mellitus. Biomarker of brain ischemia; encephalitis; and uveitis. Human ortholog(s) of this gene implicated in hepatitis B and middle cerebral artery infarction. Orthologous to human CXCL10 (C-X-C motif chemokine ligand 10). [provided by Alliance of Genome Resources, Apr 2022]

Cxcl10 Products (1)

mRNA Protein Name
NM_139089.2 NP_620789.2 C-X-C motif chemokine 10 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables chemokine activity IDA
IDA: Inferred from direct assay
9288136 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to heat IEP
IEP: Inferred from expression pattern
17457469 RGD
involved in immune response IDA
IDA: Inferred from direct assay
12023393 RGD
involved in negative regulation of angiogenesis IDA
IDA: Inferred from direct assay
9288136 RGD
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
8798675 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
8798675 RGD
involved in positive regulation of leukocyte chemotaxis IDA
IDA: Inferred from direct assay
9288136 RGD
involved in response to auditory stimulus IEP
IEP: Inferred from expression pattern
15519684 RGD
involved in response to gamma radiation IEP
IEP: Inferred from expression pattern
19084914 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
9288136 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
15637289 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in extracellular space IDA
IDA: Inferred from direct assay
17457469 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

C-X-C motif chemokine 10

  • 10 kDa interferon gamma-induced protein

  • chemokine (C-X-C motif) ligand 10

  • gamma-IP10

  • interferon-inducible cytokine IP-10

  • interferon-inducible protein 10

  • protein Mob-1

  • small inducible cytokine B subfamily (Cys-X-Cys) member 10

  • small inducible cytoki

Recombinant Cxcl10 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P7225 IP-10/CXCL10 Protein, Rat (HEK293) P48973 (I22-P98) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74797 IP-10/CXCL10 Protein, Rat (P.pastoris, His) P48973/NP_620789 (I22-P98) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-B0426A Olopatadine hydrochloride 99.83% Unkown
HY-W062109 Olopatadine 98.94% Unkown
HY-B0426AR Olopatadine hydrochloride (Standard) / Unkown

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-148511 Vidutolimod 93.85% Phase 3
Inhibitory Antibodies (4)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P99190 Eldelumab Inhibitor 99.50% Phase 2
HY-P990639 NI-0801 99.19% Phase 2
HY-P991582 BI-1607 / Phase 2
HY-P992047 BMS-986184 / Phase 1

Pre-clinical Phase

Bioactive Molecules (44)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-15319 AMG 487 Inhibitor 99.89% Unkown
HY-15589 GW9508 99.23% Unkown
HY-152237 TBK1-IN-1 Inhibitor 99.63% Unkown
HY-15320 NBI-74330 Antagonist 99.76% Unkown
HY-124151 Adenosine-2'-monophosphate Activator 99.91% Unkown
HY-111149A PS372424 hydrochloride Agonist ≥98.0% Unkown
HY-122891 SB02024 99.70% Unkown
HY-152956 STING agonist-23 Agonist 99.33% Unkown
HY-N7688 Regaloside B Inhibitor 99.90% Unkown
HY-165428 SCH-900875 Inhibitor 98.16% Unkown
HY-152959 STING agonist-26 Agonist 99.56% Unkown
HY-162675 COB-187 Inhibitor 95.0% Unkown
HY-183058 EZM8266 Inhibitor 98.24% Unkown
HY-181654 Snail IN-1 Inhibitor 98.27% Unkown
HY-111149 PS372424 Agonist / Unkown
HY-RS03384 CXCL10 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-15589R GW9508 (Standard) 98.07% Unkown
HY-113730 VUF5834 Antagonist / Unkown
HY-147129 cGAS-IN-9 Inhibitor / Unkown
HY-152957 STING agonist-24 Agonist / Unkown
HY-152958 STING agonist-25 Agonist / Unkown
HY-152961 STING agonist-28 Agonist / Unkown
HY-15319A (±)-AMG 487 Inhibitor / Unkown
HY-158036 PROTAC STING Degrader-2 / Unkown
HY-168554 STING Degrader-3 / Unkown
HY-173404 VB-85247 / Unkown
HY-174136 STING Degrader-2 / Unkown
HY-176257 STING agonist-44 Agonist / Unkown
HY-178032 PARP1-IN-44 / Unkown
HY-179288 TPST2-IN-1 Inhibitor / Unkown
HY-181484 STING agonist-50 / Unkown
HY-181877 IHCH-3185 / Unkown
HY-182926 Topoisomerase I/II-IN-9 Inhibitor / Unkown
HY-183325 FTO-IN-17 Inhibitor / Unkown
HY-183607 SMU-3k / Unkown
HY-184500 TNG917 Inhibitor / Unkown
HY-B0426AS2 Olopatadine-d6 hydrochloride / Unkown
HY-W062109S Olopatadine-d6 / Unkown
HY-W104821 Rosolic acid Activator / Unkown
HY-167884 PF-1367550 Inhibitor / Unkown
HY-172167 PD-L1/HDAC-IN-1 Inhibitor / Unkown
HY-B0426AS Olopatadine-d3 hydrochloride / Unkown
HY-RS16518 Cxcl10 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22949 Cxcl10 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P991761 Anti-Mouse CXCL10 Antibody (1F11) Inhibitor 97.564% Unkown
HY-P991208 Flt-3L-Ig (hum/hum) 98% Unkown
HY-P991989 MRG004A Antibody 95.44% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cxcl10 NCBI NCBI:3627