Il15 - interleukin 15 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25670

About Il15

Primary_assembly 19: 25,640,251-25,706,820 forward strand.mRatBN7.2:CM026992.1

This gene has 2 transcripts (splice variants), 128 orthologues and is associated with 46 phenotypes. Biased expression in Lung (RPKM 129.7), Muscle (RPKM 78.1) and 9 other tissues.

Summary

Predicted to enable cytokine activity. Involved in several processes, including cellular response to vitamin D; positive regulation of tyrosine phosphorylation of STAT protein; and skeletal muscle atrophy. Located in cell surface and extracellular space. Used to study pancreatitis. Biomarker of listeriosis and periodontal disease. Human ortholog(s) of this gene implicated in aspergillosis; asthma; pleurisy; and type 1 diabetes mellitus. Orthologous to human IL15 (interleukin 15). [provided by Alliance of Genome Resources, Apr 2022]

Il15 Products (2)

mRNA Protein Name
NM_001401135.1 NP_001388064.1 interleukin-15 preproprotein
NM_013129.3 NP_037261.1 interleukin-15 preproprotein

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in cellular response to vitamin D IEP
IEP: Inferred from expression pattern
15637289 RGD
involved in hyaluronan metabolic process IDA
IDA: Inferred from direct assay
17667861 RGD
involved in negative regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17667861 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
9826341 RGD
involved in positive regulation of protein modification process IDA
IDA: Inferred from direct assay
8942753 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
19396981 RGD
involved in skeletal muscle atrophy IEP
IEP: Inferred from expression pattern
17135303 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
16002563 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
17667861 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-15

  • IL-15

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100754 Ritlecitinib Inhibitor 99.80% Yes
HY-132580 Tofersen Inhibitor 96.53% Unkown
HY-100754C Ritlecitinib tosylate Inhibitor 99.65% Yes
HY-100754A Ritlecitinib malonate Inhibitor / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P99661 Inbakicept Activator 99.06% Unkown

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99410 Ordesekimab Inhibitor 99.08% Phase 2
HY-P990719 Efbalropendekin alfa 97.17% Phase 1

Pre-clinical Phase

Bioactive Molecules (14)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-132580A Tofersen sodium Inhibitor 97.55% Unkown
HY-15898 Y-320 99.03% Unkown
HY-102049 IL-15-IN-1 Inhibitor 99.79% Unkown
HY-Y0493 HODHBt Inhibitor 99.93% Unkown
HY-153050 JAK-IN-24 Inhibitor 99.35% Unkown
HY-RS06690 IL15 Human Pre-designed siRNA Set A / Unkown
HY-RS06691 Il15 Mouse Pre-designed siRNA Set A / Unkown
HY-RS06692 Il15 Rat Pre-designed siRNA Set A / Unkown
HY-RS06693 IL15RA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-132580S Tofersen-d27 Inhibitor / Unkown
HY-174635 Human IL15RA mRNA / Unkown
HY-174636 Human IL15 mRNA / Unkown
HY-RS19780 Il15ra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26277 Il15ra Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990223 Anti-Mouse IL-15 Antibody (AIO.3) Inhibitor 95.00% Unkown
HY-P99759 Nogapendekin alfa (his tag) Agonist 98.62% Unkown
HY-P990446 Anti-IL-15 Antibody (DISC0280) Inhibitor 99.35% Unkown
HY-P992030 FB102 / Unkown
HY-P990808 Anti-Mouse CD122/IL-2Rβ Antibody (TM-Beta 1) Inhibitor 95% Unkown
HY-P991005 Larnefpendekin alfa Inhibitor / Unkown
HY-P992375 HuMax-IL15 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il15 NCBI NCBI:3600
Mus musculus Il15 NCBI NCBI:16168
Susscrofa domestica Il15 NCBI
Macaca mulatta Il15 NCBI NCBI:699616