2. Gene
  3. Vcp - valosin containing protein Gene

Vcp - valosin containing protein Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as p97; CDC48; p97/VCP; 3110001E05

Gene ID: 269523 | Gene type: protein coding

About Vcp

Chromosome 4: 42,979,963-43,000,507 reverse strand.GRCm39:CM000997.3

This gene has 5 transcripts (splice variants), 229 orthologues, 6 paralogues and is associated with 37 phenotypes. Ubiquitous expression in placenta adult (RPKM 19.8), adrenal adult (RPKM 19.) and 28 other tissues.

Summary

Enables several functions, including ATP hydrolysis activity; K48-linked polyubiquitin modification-dependent protein binding activity; and adenyl ribonucleotide binding activity. Involved in ATP metabolic process; positive regulation of mitochondrial membrane potential; and proteasomal protein catabolic process. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process; aggresome assembly; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane and synapse. Part of ATPase complex; VCP-NSFL1C complex; and endoplasmic reticulum membrane. Is expressed in several structures, including cerebral cortex; early embryo; gonad; gut; and triceps surae muscle. Used to study inclusion body myopathy with Paget disease of bone and frontotemporal dementia. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein). [provided by Alliance of Genome Resources, Apr 2022]

Vcp Products(1)

mRNA Protein Name
NM_009503.4 NP_033529.3 transitional endoplasmic reticulum ATPase

Vcp Protein Structure

CDC48

CDC48: cl36852 (24 - 763)

  • 0
  • 200
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  • 600
  • 806 a.a.
Protein Preferred Names Protein Names

transitional endoplasmic reticulum ATPase

15S Mg(2+)-ATPase p97 subunit

AAA ATPase p97

Inv protein

TER ATPase

homolog of yeast cdc48

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-12861 CB-5083 Inhibitor 99.90% Phase 1
Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15713 NMS-873 Inhibitor 99.87% Unkown
HY-123872 MSC1094308 Inhibitor 99.89% Unkown
HY-128870 Mal-PEG2-VCP-Eribulin 99.82% Unkown
HY-15714 NMS-859 Inhibitor 98.05% Unkown
HY-130084 Mal-PEG2-VCP-NB 98.25% Unkown
HY-157508 VCP Activator 1 Activator 99.71% Unkown
HY-128871 VCP-Eribulin / Unkown
HY-113608 VCP171 Modulator / Unkown
HY-124776 NPD8733 / Unkown
HY-139606 VCP/p97 inhibitor-1 Inhibitor / Unkown
HY-148122 NW 1028 Inhibitor / Unkown
HY-RS15621 VCP Human Pre-designed siRNA Set A / Unkown
HY-RS15622 Vcp Mouse Pre-designed siRNA Set A / Unkown
HY-RS15623 Vcp Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vcp NCBI NCBI:7415