GPR35 - G protein-coupled receptor 35 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2859

About GPR35

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:240,605,430-240,633,159 (from NCBI)

This gene has 5 transcripts (splice variants), 228 orthologues, 16 paralogues and is associated with 1 phenotype. Biased expression in duodenum (RPKM 17.7), small intestine (RPKM 16.7) and 7 other tissues.

Summary

Enables C-X-C Chemokine Receptor activity. Involved in several processes, including chemokine-mediated signaling pathway; negative regulation of voltage-gated Calcium Channel activity; and positive regulation of cytosolic calcium ion concentration. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR35 Products (4)

mRNA	Protein	Name
NM_001195381.3	NP_001182310.1	G-protein coupled receptor 35 isoform b
NM_001195382.3	NP_001182311.1	G-protein coupled receptor 35 isoform b
NM_005301.5	NP_005292.2	G-protein coupled receptor 35 isoform a
NM_001394730.1	NP_001381659.1	G-protein coupled receptor 35 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables C-X-C chemokine receptor activity	IDA IDA: Inferred from direct assay	29068046	GOA
enables C-X-C chemokine receptor activity	IMP IMP: Inferred from mutant phenotype	25411203	GOA
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	16754668	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	16754668	GOA
involved in chemokine-mediated signaling pathway	IDA IDA: Inferred from direct assay	25411203	GOA
involved in chemokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	25411203	GOA
involved in negative regulation of voltage-gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	17940199	GOA
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	25411203	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	16754668	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR35 Protein Structure

7tm_1

0
100
200
309 a.a.

Protein Preferred Names	Protein Names
G-protein coupled receptor 35	KYNA receptor kynurenic acid receptor

Related Diseases

Diseases	Alias
Short-Rib Thoracic Dysplasia 10 With Or Without Polydactyly	SRTD10 Short-Rib Thoracic Dysplasia 10 Without Polydactyly Short Rib-Polydactyly Syndrome
Cholangitis, Primary Sclerosing	Primary Sclerosing Cholangitis PSC Sclerosing Cholangitis Cholangitis, Sclerosing Cholangitis Primary Sclerosing Psc - [Primary Sclerosing Cholangitis]
Microphthalmia, Isolated 1	Isolated Microphthalmia 1 MCOP1 Mcop Anophthalmia, Clinical, Isolated Microphthalmos, Autosomal Recessive
Retinitis Pigmentosa 71	RP71 Retinitis Pigmentosa, Type 71

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	상품명	효과	Purity	Phase
HY-100806	Kynurenic acid	Agonist	99.93%	Phase 1
HY-100806R	Kynurenic acid (Standard)	Agonist	98.87%	Phase 1

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-B1816	Zaprinast	Agonist	99.88%	Unkown
HY-107537	CID 2745687	Agonist	99.35%	Unkown
HY-W008613	Pamoic acid	Agonist	99.69%	Unkown
HY-100806S	Kynurenic acid-d5	Agonist	99.85%	Unkown
HY-107512	Kynurenic acid sodium	Agonist	99.82%	Unkown
HY-W018158	DHICA	Activator	96.91%	Unkown
HY-107536	ML 145		96.09%	Unkown
HY-W010907	Pamoic acid disodium	Agonist	99.86%	Unkown
HY-16639	ML314		99.52%	Unkown
HY-101033	GPR35 agonist 1		99.89%	Unkown
HY-134801	CID1231538		99.26%	Unkown
HY-106481	Bufrolin	Agonist	95.16%	Unkown
HY-15705	GPR35 agonist 2	Agonist	98.61%	Unkown
HY-107539	GPR35 agonist 4	Agonist	99.32%	Unkown
HY-107538	YE120	Agonist	99.93%	Unkown
HY-101958	Tyrphostin 25	Agonist	99.00%	Unkown
HY-149190	GPR35 agonist 5	Agonist	98.86%	Unkown
HY-W018158R	DHICA (Standard)	Activator	95.20%	Unkown
HY-169301	Gpr35 modulator 1	Modulator	/	Unkown
HY-169302	GPR35 activator-1	Activator	/	Unkown
HY-169303	Gpr35 modulator 2	Modulator	/	Unkown
HY-169304	Gpr35 modulator 3	Modulator	/	Unkown
HY-131728	GPR35 agonist 3	Agonist	98.32%	Unkown
HY-167706	Diethyl-Lodoxamide		/	Unkown
HY-W1058476	GPR35 agonist 6	Agonist	/	Unkown
HY-178725	ML301	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GPR35	VGNC	VGNC:73134
Canis familiaris	GPR35	VGNC	VGNC:110509
Mus musculus	GPR35	MGD	MGI:1929509
Bos taurus	GPR35	VGNC	VGNC:29584
Rattus norvegicus	GPR35	RGD	RGD:1309404
Felis catus	GPR35	VGNC	VGNC:67425
Others	GPR35	NCBI