2. Gene
  3. Hras - HRas proto-oncogene, GTPase Gene

Hras - HRas proto-oncogene, GTPase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as HRAS1; c-H-ras

Gene ID: 293621 | Gene type: protein coding

About Hras

Primary_assembly 1: 196,296,263-196,300,615 reverse strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 224 orthologues, 41 paralogues and is associated with 104 phenotypes. Biased expression in Muscle (RPKM 343.7), Brain (RPKM 196.6) and 9 other tissues.

Summary

Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular senescence; positive regulation of DNA replication; and positive regulation of ERK1 and ERK2 cascade. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in intracellular membrane-bounded organelle and plasma membrane. Used to study diabetic retinopathy and liver carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Hras Products(2)

mRNA Protein Name
NM_001130441.1 NP_001123913.1 GTPase HRas
NM_001098241.1 NP_001091711.1 GTPase HRas

Hras Protein Structure

H_N_K_Ras_like

H_N_K_Ras_like: cd04138 (103 - 264)

  • 0
  • 100
  • 200
  • 290 a.a.
Protein Preferred Names Protein Names

GTPase HRas

H-Ras-1

Harvey ras1 protein

Harvey rat sarcoma viral (v-Ha-ras) oncogene homolog

Harvey rat sarcoma virus oncogene

p21ras

transforming protein p21

Related Agents

Approval
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0660 Eicosapentaenoic Acid Activator ≥98.0% Yes
HY-15136 Lonafarnib 99.87% Yes
HY-W011269 Eicosapentaenoic Acid sodium Activator / Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-16373 CP-609754 Inhibitor 99.87% Phase 1
Pre-clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100002 ML162 99.35% Unkown
HY-156498 RMC-7977 Inhibitor 99.12% Unkown
HY-122862 RAS inhibitor Abd-7 Inhibitor 99.16% Unkown
HY-113849 MLS-573151 Inhibitor 99.74% Unkown
HY-18674 K-Ras-IN-1 Inhibitor 98.05% Unkown
HY-145962A MRTX-EX185 formic Inhibitor 97.32% Unkown
HY-123242 FTI-2153 Inhibitor 98.48% Unkown
HY-125904 4-Hydroxyretinoic acid Activator 95.11% Unkown
HY-15879 LB42708 ≥99.0% Unkown
HY-123242A FTI-2153 TFA Inhibitor 99.11% Unkown
HY-145962 MRTX-EX185 Inhibitor / Unkown
HY-115489 GGTI-286 Inhibitor / Unkown
HY-115489A GGTI-286 TFA Inhibitor / Unkown
HY-117935 GGTI-286 hydrochloride Inhibitor / Unkown
HY-151263 G4/HDAC-IN-1 / Unkown
HY-15136B (Rac)-Lonafarnib / Unkown
HY-RS06354 HRAS Human Pre-designed siRNA Set A / Unkown
HY-RS06355 Hras Mouse Pre-designed siRNA Set A / Unkown
HY-RS06356 Hras Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hras NCBI NCBI:3265