Dld - dihydrolipoamide dehydrogenase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 298942

Summary

This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. A similar protein in human, mouse, and pig has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In homodimeric form, the protein functions as a dehydrogenase and is found in several multi-enzyme complexes that regulate energy metabolism. However, as a monomer, the protein can function as a protease. [provided by RefSeq, Jan 2014]

Dld Products (1)

mRNA Protein Name
NM_199385.2 NP_955417.1 dihydrolipoyl dehydrogenase, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables NAD binding IDA
IDA: Inferred from direct assay
3753688 RGD
enables dihydrolipoyl dehydrogenase activity IDA
IDA: Inferred from direct assay
7487891 RGD
enables flavin adenine dinucleotide binding IDA
IDA: Inferred from direct assay
3753688 RGD
enables lipoamide binding IDA
IDA: Inferred from direct assay
8981046 RGD
Biological Process GO Annotation Evidence References Source
involved in 2-oxoglutarate metabolic process IDA
IDA: Inferred from direct assay
3571202 RGD
involved in acetyl-CoA biosynthetic process from pyruvate IDA
IDA: Inferred from direct assay
7487891 RGD
involved in dihydrolipoamide metabolic process IDA
IDA: Inferred from direct assay
8981046 RGD
involved in lipoate metabolic process IDA
IDA: Inferred from direct assay
8981046 RGD
Cellular Component GO Annotation Evidence References Source
part of oxoglutarate dehydrogenase complex IDA
IDA: Inferred from direct assay
3571202 RGD
part of pyruvate dehydrogenase complex IDA
IDA: Inferred from direct assay
7487891 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dihydrolipoyl dehydrogenase, mitochondrial

  • dihydrolipoamide dehydrogenase (E3 component of pyruvate dehydrogenase complex, 2-oxo-glutarate complex, branched chain keto acid dehydrogenase complex)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (27)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122312 BAY-8002 Inhibitor 98.84% Unkown
HY-139691 SR15006 Inhibitor 99.90% Unkown
HY-177512 MSC778 Inhibitor / Unkown
HY-119257 ABT-100 ≥98.0% Unkown
HY-169652 NPC26 Activator 98.0% Unkown
HY-156375 PKM2 activator 6 / Unkown
HY-120667 DS-5272 / Unkown
HY-118829 3,4-Methylenedioxy PV9 hydrochloride 99.90% Unkown
HY-153674 PROTAC SOS1 degrader-4 Degrader / Unkown
HY-161654 PROTAC SOS1 degrader-10 / Unkown
HY-163816 Antiproliferative agent-53-d3 Inhibitor / Unkown
HY-165606 SB-T-1214 Inducer / Unkown
HY-168716 SOS1-IN-17 Inhibitor / Unkown
HY-168733 LDHA-IN-9 / Unkown
HY-176701 PRMT5-MTA-IN-4 Inhibitor / Unkown
HY-177967 Antitumor agent-209 / Unkown
HY-179413 Polθ-IN-9 Inhibitor / Unkown
HY-RS03794 DLD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04711 FAM3A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07574 LDHD Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-121619 Jacaric acid Inducer / Unkown
HY-122063 FR260330 Inhibitor / Unkown
HY-N13886 Anicequol / Unkown
HY-N7305 Jatrophane 5 Inhibitor / Unkown
HY-RS19107 Dld Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25597 Dld Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W098807 4-Chloro-7-ethoxyquinoline / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dld NCBI NCBI:1738