PARP14 - poly(ADP-ribose) polymerase family member 14 Gene

Also Known as BAL2; ARTD8; pART8; PARP-14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54625

About PARP14

Cytogenetic location: 3q21.1 Genomic coordinates (GRCh38): 3:122,680,839-122,730,840 (from NCBI)

This gene has 7 transcripts (splice variants), 295 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 17.4), appendix (RPKM 15.1) and 24 other tissues.

Summary

This gene encodes a member of the poly(ADP-ribose) polymerase (PARP) protein family. The encoded anti-apoptotic protein may regulate aerobic glycolysis and promote survival of Cancer cells. Increased expression of this gene has been reported in a variety of tumor types. [provided by RefSeq, Jul 2016]

PARP14 Products (3)

mRNA	Protein	Name
NM_017554.3	NP_060024.2	protein mono-ADP-ribosyltransferase PARP14
XM_011512929.3	XP_011511231.1	protein mono-ADP-ribosyltransferase PARP14 isoform X1
XR_007095695.1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NAD+ binding	IMP IMP: Inferred from mutant phenotype	16061477	GOA
enables NAD+-protein ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	18851833	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA IDA: Inferred from direct assay	27796300	GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity	IMP IMP: Inferred from mutant phenotype	16061477	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	27796300	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23473667	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	27796300	GOA
involved in negative regulation of type II interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	27796300	GOA
involved in negative regulation of tyrosine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	27796300	GOA
involved in positive regulation of interleukin-4-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	27796300	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IMP IMP: Inferred from mutant phenotype	27796300	GOA
involved in protein poly-ADP-ribosylation	IMP IMP: Inferred from mutant phenotype	16061477	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	27796300	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PARP14 Protein Structure

Macro

WWE

PARP

0
300
600
900
1200
1500
1801 a.a.

Protein Preferred Names	Protein Names
protein mono-ADP-ribosyltransferase PARP14	ADP-ribosyltransferase diphtheria toxin-like 8 B-aggressive lymphoma 2 b aggressive lymphoma protein 2 collaborator of STAT6 poly [ADP-ribose] polymerase 14

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia 44	SCA44
Alcohol-Related Birth Defects	Arbd Alcohol-Related Birth Defect Alcohol Related Birth Defect Fetal Alcohol Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-150207	RBN-3143	Inhibitor	99.29%	Phase 1

Pre-clinical Phase

Bioactive Molecules (16)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136979	RBN012759	Inhibitor	99.33%	Unkown
HY-148566	OUL232	Inhibitor	99.86%	Unkown
HY-117889	PARP14 inhibitor H10	Inhibitor	99.46%	Unkown
HY-108708	GeA-69	Inhibitor	99.91%	Unkown
HY-148754	PARP10-IN-3	Inhibitor	98.72%	Unkown
HY-173679	RBN012811	Degrader	98.79%	Unkown
HY-155993	YCH1899	Inhibitor	99.39%	Unkown
HY-148753	PARP10-IN-2	Inhibitor	98.07%	Unkown
HY-121719	TIQ-A	Inhibitor	99.85%	Unkown
HY-143338	ART-IN-1	Inhibitor	98.91%	Unkown
HY-W294889	OUL245	Inhibitor	/	Unkown
HY-172806	PARP14 inhibitor 1	Inhibitor	/	Unkown
HY-148709	ARTD10/PARP10-IN-1	Inhibitor	/	Unkown
HY-148710	ARTD10/PARP10-IN-2	Inhibitor	/	Unkown
HY-176456	PARP14 inhibitor 2	Inhibitor	/	Unkown
HY-183548	XW-17	Ligand	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PARP14	VGNC	VGNC:84054
Felis catus	PARP14	VGNC	VGNC:102797
Mus musculus	PARP14	MGD	MGI:1919489
Rattus norvegicus	PARP14	RGD	RGD:1310490
Canis familiaris	PARP14	VGNC	VGNC:53082
Others	PARP14	NCBI