Top1 - DNA topoisomerase I Gene

Also Known as Ab2-086

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64550

About Top1

Primary_assembly 3: 149,293,403-149,376,623 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 273 orthologues, 1 paralogue and is associated with 7 phenotypes. Biased expression in Spleen (RPKM 242.9), Thymus (RPKM 228.2) and 9 other tissues.

Summary

Enables DNA Topoisomerase type I (single strand cut, ATP-independent) activity and chromatin DNA binding activity. Involved in several processes, including cellular response to luteinizing hormone stimulus; nucleic acid metabolic process; and response to gamma radiation. Located in dense fibrillar component and fibrillar center. Orthologous to human TOP1 (DNA Topoisomerase I). [provided by Alliance of Genome Resources, Apr 2022]

Top1 Products (1)

mRNA Protein Name
NM_022615.2 NP_072137.1 DNA topoisomerase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA binding IDA
IDA: Inferred from direct assay
10469141 RGD
enables DNA topoisomerase type I (single strand cut, ATP-independent) activity IDA
IDA: Inferred from direct assay
1332866 RGD
enables chromatin DNA binding IDA
IDA: Inferred from direct assay
1332866 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
2851418 RGD
Biological Process GO Annotation Evidence References Source
involved in DNA topological change IDA
IDA: Inferred from direct assay
1332866 RGD
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
1332866 RGD
involved in cellular response to luteinizing hormone stimulus IEP
IEP: Inferred from expression pattern
2822514 RGD
involved in rRNA transcription IMP
IMP: Inferred from mutant phenotype
3033639 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
2822514 RGD
involved in response to gamma radiation IEP
IEP: Inferred from expression pattern
2853856 RGD
involved in response to temperature stimulus IEP
IEP: Inferred from expression pattern
9076473 RGD
Cellular Component GO Annotation Evidence References Source
located in dense fibrillar component IDA
IDA: Inferred from direct assay
11170002 RGD
located in fibrillar center IDA
IDA: Inferred from direct assay
17587596 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Top1 Protein Structure

Topoisomer_IB_N_htopoI_like

Topoisomer_IB_N_htopoI_like: cd03488 (217 - 431)

TOPEUc

TOPEUc: smart00435 (361 - 738)

  • 0
  • 200
  • 400
  • 600
  • 767 a.a.
Protein Preferred Names Protein Names

DNA topoisomerase 1

  • topoisomerase (DNA) I

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16560 Camptothecin 99.77% Unkown

Clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Phase
HY-171689 Puxitatug samrotecan Inhibitor 98.51% Phase 3
HY-U00248A LMP744 hydrochloride Inhibitor 99.08% Phase 2
HY-168739 Topoisomerase I inhibitor 17 / Phase 2
HY-171124 Tilatamig samrotecan Inhibitor 95.26% Phase 1
HY-18350 Indimitecan Inhibitor 98.30% Phase 1
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990940 Precemtabart Inhibitor 99.00% Phase 3

Pre-clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-164734 Raludotatug Deruxtecan 99.29% Unkown
HY-148819A NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT hydrochloride Inhibitor 98.46% Unkown
HY-148819 NH2-bicyclo[1.1.1]pentane-7-MAD-MDCPT Inhibitor 98.71% Unkown
HY-163099 P5(PEG24)-VC-PAB-Exatecan 99.74% Unkown
HY-153278 Q901 Inhibitor 98.38% Unkown
HY-U00248 LMP744 Inhibitor 98.33% Unkown
HY-153278A Q901 TFA Inhibitor / Unkown
HY-160005 LMP517 Inhibitor 99.20% Unkown
HY-175203 Topi MF-6 Inhibitor 99.79% Unkown
HY-W008874 meso-Tetra(4-pyridyl)porphine Inhibitor 98.0% Unkown
HY-N0114A (±)-Evodiamine 99.74% Unkown
HY-126142 Top1 inhibitor 1 Inhibitor 99.67% Unkown
HY-RS14893 TOP1MT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-118942 Topovale Inhibitor 99.94% Unkown
HY-143265 Topoisomerase I inhibitor 2 / Unkown
HY-144794 EGFR-IN-46 / Unkown
HY-146437 Topoisomerase I inhibitor 6 Inhibitor / Unkown
HY-149348 DiPT-4 / Unkown
HY-159935 Top1-IN-2 Inhibitor / Unkown
HY-161957 Top1/2-IN-1 Inhibitor / Unkown
HY-16560B (R)-Camptothecin Control / Unkown
HY-178036 ZM484 Inhibitor / Unkown
HY-180555 SN38-(PEG)2-Pom-α Activator / Unkown
HY-181080 TOP1/TDP1-IN-1 / Unkown
HY-18350A Indimitecan hydrochloride Inhibitor / Unkown
HY-184245 Hsp90-IN-48 Inhibitor / Unkown
HY-184984 SN-38-A2 Degrader / Unkown
HY-N15249 4"-Isovalerylspiramycin I / Unkown
HY-RS14890 TOP1 Human Pre-designed siRNA Set A / Unkown
HY-RS14891 Top1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS14892 Top1 Rat Pre-designed siRNA Set A / Unkown
HY-W654323 PNU-142586 sodium Inhibitor / Unkown
HY-133219 Guajadial C Inhibitor / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990947 Tilatamig Inhibitor 99.99% Unkown
HY-P991164 Torvutatug Inhibitor 99% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Top1 NCBI NCBI:7150