2. Gene
  3. Top1 - DNA topoisomerase I Gene

Top1 - DNA topoisomerase I Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Ab2-086

Gene ID: 64550 | Gene type: protein coding

About Top1

Primary_assembly 3: 149,293,403-149,376,623 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 273 orthologues, 1 paralogue and is associated with 7 phenotypes. Biased expression in Spleen (RPKM 242.9), Thymus (RPKM 228.2) and 9 other tissues.

Summary

Enables DNA Topoisomerase type I (single strand cut, ATP-independent) activity and chromatin DNA binding activity. Involved in several processes, including cellular response to luteinizing hormone stimulus; nucleic acid metabolic process; and response to gamma radiation. Located in dense fibrillar component and fibrillar center. Orthologous to human TOP1 (DNA Topoisomerase I). [provided by Alliance of Genome Resources, Apr 2022]

Top1 Products(1)

mRNA Protein Name
NM_022615.2 NP_072137.1 DNA topoisomerase 1

Top1 Protein Structure

Topoisomer_IB_N_htopoI_like

Topoisomer_IB_N_htopoI_like: cd03488 (217 - 431)

TOPEUc

TOPEUc: smart00435 (361 - 738)

  • 0
  • 200
  • 400
  • 600
  • 767 a.a.
Protein Preferred Names Protein Names

DNA topoisomerase 1

topoisomerase (DNA) I

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16560 Camptothecin 99.82% Unkown
Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-U00248A LMP744 hydrochloride Inhibitor 99.70% Phase 1
HY-U00248 LMP744 Inhibitor 97.00% Phase 1
Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0114A (±)-Evodiamine 99.97% Unkown
HY-18350 Indimitecan Inhibitor 98.03% Unkown
HY-126142 Top1 inhibitor 1 Inhibitor / Unkown
HY-143265 Topoisomerase I inhibitor 2 / Unkown
HY-144794 EGFR-IN-46 / Unkown
HY-146437 Topoisomerase I inhibitor 6 Inhibitor / Unkown
HY-149348 DiPT-4 / Unkown
HY-160005 LMP517 Inhibitor / Unkown
HY-RS14890 TOP1 Human Pre-designed siRNA Set A / Unkown
HY-RS14891 Top1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS14892 Top1 Rat Pre-designed siRNA Set A / Unkown
HY-RS14893 TOP1MT Human Pre-designed siRNA Set A / Unkown
HY-118942 Topovale Inhibitor / Unkown
HY-133219 Guajadial C Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Top1 NCBI NCBI:7150
Mus musculus Top1 NCBI NCBI:21969