Dyrk2 - dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 Gene

Also Known as 1810038L18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 69181

About Dyrk2

Chromosome 10: 118,691,508-118,706,114 reverse strand.GRCm39:CM001003.3

This gene has 3 transcripts (splice variants), 208 orthologues, 12 paralogues and is associated with 14 phenotypes. Ubiquitous expression in CNS E18 (RPKM 1.4), large intestine adult (RPKM 9.8) and 28 other tissues.

Summary

Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of calcineurin-NFAT signaling cascade; and protein phosphorylation. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation. Part of ribonucleoprotein complex. Is expressed in several structures, including brain; eye; gut gland; hemolymphoid system gland; and reproductive system. Orthologous to human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Dyrk2 Products (1)

mRNA Protein Name
NM_001014390.2 NP_001014412.1 dual specificity tyrosine-phosphorylation-regulated kinase 2

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
21709260 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dyrk2 Protein Structure

PKc_DYRK2_3

PKc_DYRK2_3: cd14224 (153 - 532)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 599 a.a.
Protein Preferred Names Protein Names

dual specificity tyrosine-phosphorylation-regulated kinase 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-105309 GSK-626616 Inhibitor 99.88% Unkown
HY-112296 T025 Inhibitor 99.64% Unkown
HY-U00439A Protein kinase inhibitor 1 hydrochloride Inhibitor 98.0% Unkown
HY-117049 Leucettine L41 Inhibitor 98.98% Unkown
HY-146221 Dyrk1A-IN-5 Inhibitor 98.06% Unkown
HY-153949 YK-2-69 Inhibitor 99.57% Unkown
HY-147066 Dyrk1A-IN-4 Inhibitor 99.30% Unkown
HY-125290 MU1210 Inhibitor 99.50% Unkown
HY-111379 EHT 5372 Inhibitor 98.12% Unkown
HY-13455 LDN-192960 Inhibitor 99.58% Unkown
HY-156816 ON 108600 Inhibitor 98.65% Unkown
HY-13455A LDN-192960 hydrochloride Inhibitor 99.76% Unkown
HY-162750 ZJCK-6-46 Inhibitor 99.06% Unkown
HY-110320 LDN-209929 dihydrochloride Inhibitor 98.33% Unkown
HY-161597 PROTAC DYRK2 degrader 1 Degrader / Unkown
HY-402805 DYRK2-IN-2 Inhibitor / Unkown
HY-402805A DYRK2-IN-2 hydrochloride Inhibitor / Unkown
HY-172198 GSK3-IN-10 Inhibitor / Unkown
HY-177416 MU1787 Inhibitor / Unkown
HY-161598 DYRK2 ligand 1 Degrader / Unkown
HY-181085 RD0448 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dyrk2 NCBI NCBI:8445