Dyrk2 - dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 Gene

Mus musculus

Also known as 1810038L18Rik

Gene ID: 69181 | Gene type: protein coding

About Dyrk2

Chromosome 10: 118,691,508-118,706,114 reverse strand.GRCm39:CM001003.3

This gene has 3 transcripts (splice variants), 208 orthologues, 12 paralogues and is associated with 14 phenotypes. Ubiquitous expression in CNS E18 (RPKM 1.4), large intestine adult (RPKM 9.8) and 28 other tissues.

Summary

Predicted to enable ATP binding activity; metal ion binding activity; and protein kinase activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of calcineurin-NFAT signaling cascade; and protein phosphorylation. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation. Part of ribonucleoprotein complex. Is expressed in several structures, including brain; eye; gut gland; hemolymphoid system gland; and reproductive system. Orthologous to human DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Dyrk2 Products(1)

mRNA	Protein	Name
NM_001014390.2	NP_001014412.1	dual specificity tyrosine-phosphorylation-regulated kinase 2

Dyrk2 Protein Structure

PKc_DYRK2_3

0
100
200
300
400
500
599 a.a.

Protein Preferred Names

Protein Names

dual specificity tyrosine-phosphorylation-regulated kinase 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-112296	T025	Inhibitor	98.84%	Unkown
HY-U00439A	Protein kinase inhibitor 1 hydrochloride	Inhibitor	≥98.0%	Unkown
HY-111379	EHT 5372	Inhibitor	98.12%	Unkown
HY-146221	Dyrk1A-IN-5	Inhibitor	98.56%	Unkown
HY-147066	Dyrk1A-IN-4	Inhibitor	99.90%	Unkown
HY-156816	ON 108600	Inhibitor	99.73%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Dyrk2	NCBI	NCBI:8445

Name
Email *

	Sorry, but the email address you supplied was invalid.