GSK3β-IN-3
GSK3β-IN-3 is an ATP-competitive GSK-3β inhibitor (IC50 = 0.90 μM). GSK3β-IN-3 can reduce the phosphorylation level of tau protein in the BR5706 strain and reduce the deposition of Aβ aggregates in the CL2006 strain, and can be used to research Alzheimer's disease (AD).
For research use only. We do not sell to patients.
- CAS No.: 301359-45-5
- Formula: C14H15ClN2O2S
- Molecular Weight:310.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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GSK3β 0.90 μM (IC50) |
GSK3β-IN-3 (Compound 66) (10 μM) reduces p-Tau (Ser396) levels in the BR5706 strain in C. elegans[1].
GSK3β-IN-3 (10 μM) increases quantity of thrashes, reduces Aβ deposition in the CL2006 C. elegans strain[1].
GSK3β-IN-3 shows good stability in human microsomes[1].
GSK3β-IN-3 has the potential to cross the BBB in PAMPA-BBB test[1].
GSK3β-IN-3 has high plasma protein binding, shows plasma protein binding 96.4%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 301359-45-5
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Molecular Weight 310.80
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Formula C14H15ClN2O2S
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SMILES
CCOC(C1=C(NC(NC1C2=CC=CC=C2Cl)=S)C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK3β-IN-3 Related Classifications
HY-W098905 Related Classifications
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