hCAIX-IN-15
hCAIX-IN-15 is a potent hCA IX inhibitor with a Ki value of 38.8 nM. hCAIX-IN-15 shows good broad-spectrum anticancer activity and can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 2849348-43-0
- Formula: C18H14FN7O2S
- Molecular Weight:411.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hCA IX 38.8 nM (Ki) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-468 | IC50 |
1.48 μM
Compound: 84
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Anticancer activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay
Anticancer activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 48 hrs by SRB assay
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[PMID: 39018924] |
hCAIX-IN-15 (compound 12i; 48 h) has best cytotoxicity towards renal cancer (UO-31), breast cancer (MDA-MB-468) and non-small cell lung cancer (HOP-92) cell lines, with GI% = 20%, 17% and 16% respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2849348-43-0
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Molecular Weight 411.41
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Formula C18H14FN7O2S
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SMILES
O=S(C1=CC=C(NC2=NC(N)=NC(/C(C#N)=C/C3=CC=CC(F)=C3)=N2)C=C1)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
hCAIX-IN-15 Related Classifications
HY-151632 Related Classifications
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