VTX-0811
VTX-0811 is a human IgG4 monoclonal antibody (mAb) targeting PSGL1/CD162. VTX-0811 up-regulates TNF-α/NF-κB and chemokine-mediated signaling and down-regulates oxidative phosphorylation, fatty acid metabolism, and Myc signaling pathways. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells. VTX-0811 has antitumor activity in a humanized mouse PDX model of melanoma.
For research use only. We do not sell to patients.
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Species Reactivity
Human
IC50 & Target
PSGL1/CD162
Gene ID
Accession
Conjugated
Unconjugated
Reconstitution
The product can be reconstituted/diluted with sterile PBS or saline.
Application
ELISA, FACS, Functional assay
Chemical Information
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SMILES
[VTX-0811]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Hot Topics
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Topics
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Topics Oxidative Phosphorylation: Cancer & Beyond Therapeutic Target
Oxidative phosphorylation (OXPHOS) is the mitochondrial energy-conversion process in which the electron transport chain uses reducing equivalents from NADH and FADH2 to generate a proton gradient that drives ATP synthase.
2026-06-18
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
VTX-0811 Related Classifications
HY-P991432 Related Classifications
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