HPK1-IN-35
HPK1-IN-35 is a potent and selective HPK1 inhibitor with an IC50 value of 3.5 nM. HPK1-IN-35 decreases the expression of p-SLP76 and promotes IL-2 secretion.
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2935903-77-6
- Fòrmula: C30H32N8O3S
- Peso molecular:584.69
-
Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas MAP4K
More
Actividad biológica
|
HPK1 3.5 nM (IC50) |
HPK1-IN-35 (compound 31) (0.1, 0.3, 1, 3 µM; 1 h) decreases the expression of p-SLP76 stimulated by anti-CD3 antibody (1 µg/mL) in a dose-dependent manner[1].
HPK1-IN-35 (0-10 µM; 24 h) promotes IL-2 secretion in Jurkat cells in a dose-dependent manner with EC50 values of 1.19 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Jurkat cells
-
Concentration:0.1, 0.3, 1, 3 µM
-
Incubation Time:1 h
-
Result:Dose-dependently suppressed the phosphorylation of SLP76 stimulated by anti-CD3 antibody in Jurkat cells with IC50 values of 1.04 µM.
Chemical Information
-
No. CAS 2935903-77-6
-
Peso molecular 584.69
-
Fòrmula C30H32N8O3S
-
SMILES
COC1=C(C=C2CN(CCC2=C1)C)NC3=NC4=C(C(NC5=CC=CC=C5S(=O)(N(C)C)=O)=N3)C(C6=CC=CN=C6)=CN4
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HPK1-IN-35 Related Classifications
HY-149232 Related Classifications
Powered by Bioz