2. MAPK/ERK Pathway
  3. MAP4K
  4. HPK1-IN-35

HPK1-IN-35 is a potent and selective HPK1 inhibitor with an IC50 value of 3.5 nM. HPK1-IN-35 decreases the expression of p-SLP76 and promotes IL-2 secretion.

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HPK1-IN-35 Chemical Structure

HPK1-IN-35 Chemical Structure

CAS No. : 2935903-77-6

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HPK1-IN-35 Related Antibodies

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Description

HPK1-IN-35 is a potent and selective HPK1 inhibitor with an IC50 value of 3.5 nM. HPK1-IN-35 decreases the expression of p-SLP76 and promotes IL-2 secretion[1].

IC50 & Target[1]

HPK1

3.5 nM (IC50)

In Vitro

HPK1-IN-35 (compound 31) (0.1, 0.3, 1, 3 µM; 1 h) decreases the expression of p-SLP76 stimulated by anti-CD3 antibody (1 µg/mL) in a dose-dependent manner[1].
HPK1-IN-35 (0-10 µM; 24 h) promotes IL-2 secretion in Jurkat cells in a dose-dependent manner with EC50 values of 1.19 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HPK1-IN-35 Related Antibodies

Western Blot Analysis [1]

Cell Line: Jurkat cells
Concentration: 0.1, 0.3, 1, 3 µM
Incubation Time: 1 h
Result: Dose-dependently suppressed the phosphorylation of SLP76 stimulated by anti-CD3 antibody in Jurkat cells with IC50 values of 1.04 µM.
Molecular Weight

584.69

Formula

C30H32N8O3S
CAS No.
SMILES

COC1=C(C=C2CN(CCC2=C1)C)NC3=NC4=C(C(NC5=CC=CC=C5S(=O)(N(C)C)=O)=N3)C(C6=CC=CN=C6)=CN4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HPK1-IN-35 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HPK1-IN-352935903-77-6MAP4KMAPK Kinase Kinase Kinasep-SLP76Jurkat cellsIL-2Inhibitorinhibitorinhibit

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HY-149232
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