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Art. -Nr.: HY-149232

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HPK1-IN-35

HPK1-IN-35 is a potent and selective HPK1 inhibitor with an IC₅₀ value of 3.5 nM. HPK1-IN-35 decreases the expression of p-SLP76 and promotes IL-2 secretion.

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CAS. Nr.: 2935903-77-6
Formel: C₃₀H₃₂N₈O₃S
Molecular Weight:584.69

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

HPK1-IN-35 Chemical Structure

CAS. Nr.: 2935903-77-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

HPK1-IN-35 is a potent and selective HPK1 inhibitor with an IC₅₀ value of 3.5 nM. HPK1-IN-35 decreases the expression of p-SLP76 and promotes IL-2 secretion^[1].

IC₅₀ & Target^[1]

HPK1

3.5 nM (IC₅₀)

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In Vitro

HPK1-IN-35 (compound 31) (0.1, 0.3, 1, 3 µM; 1 h) decreases the expression of p-SLP76 stimulated by anti-CD3 antibody (1 µg/mL) in a dose-dependent manner^[1].
HPK1-IN-35 (0-10 µM; 24 h) promotes IL-2 secretion in Jurkat cells in a dose-dependent manner with EC50 values of 1.19 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Jurkat cells
Concentration:

0.1, 0.3, 1, 3 µM
Incubation Time:

1 h
Result:

Dose-dependently suppressed the phosphorylation of SLP76 stimulated by anti-CD3 antibody in Jurkat cells with IC50 values of 1.04 µM.

Chemical Information

CAS. Nr. 2935903-77-6
Molecular Weight 584.69
Formel C₃₀H₃₂N₈O₃S
SMILES

COC1=C(C=C2CN(CCC2=C1)C)NC3=NC4=C(C(NC5=CC=CC=C5S(=O)(N(C)C)=O)=N3)C(C6=CC=CN=C6)=CN4
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Feifei Wu, et al. Discovery of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors. European Journal of Medicinal Chemistry. 2023, 254: 115355.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
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HPK1-IN-35

Alle MAP4K Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

HPK1-IN-35 Related Classifications

HY-149232 Related Classifications