ICA604025

ICA604025 (0.001-100 μM; 4 minutes) potently and state-dependently inhibits human Nav1.9-5C channels in HEK-293 cells, with an EC₅₀ of 9 nM for activated/inactivated states and 1.1 μM for resting closed states^[1].
ICA604025 (0.001-100 μM; 4 minutes) potently and state-dependently inhibits wild-type human Nav1.9 channels in HEK-293 cells, with an EC₅₀ of 10 nM for activated/inactivated states and 0.76 μM for resting closed states^[1].
ICA604025 (0.001-100 μM; 4 minutes) potently and state-dependently inhibits cynomolgus monkey Nav1.9 channels in HEK-293 cells, with an EC₅₀ of 10 nM for activated/inactivated states and 0.45 μM for resting closed states^[1].
ICA604025 (0.001-100 μM; 4 minutes) inhibits mouse Nav1.9 channels in HEK-293 cells with an EC₅₀ of 0.48 μM for activated/inactivated states, showing ~48-fold lower potency than for human Nav1.9^[1].
ICA604025 (0.001-100 μM; 4 minutes) inhibits rat Nav1.9 channels in HEK-293 cells with an EC₅₀ of 0.53 μM for activated/inactivated states, showing ~53-fold lower potency than for human Nav1.9^[1].
ICA604025 (0.001-100 μM; 4 minutes) inhibits human Nav1.9-5C^{F1592A/Y1599A} mutant channels in HEK-293 cells with an EC₅₀ of 0.017 μM for activated/inactivated states, showing only a minor reduction in potency compared to wild-type Nav1.9-5C^[1].
ICA604025 (0-10 μM) potently inhibits native Nav1.9 channels in human DRG neurons with an IC₅₀ of 0.56 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.