Cat. No.: HY-B1360

Chlorquinaldol

(Synonyms: Chloquinan)

6 Cited Publications

Customer Review

Based on 6 publication(s) in Google Scholar

Chlorquinaldol (Chloquinan) is an antibacterial agent with the potential use in topical skin conditions and vaginal infections. Chlorquinaldol is a β-catenin/TCF4 inhibitor, showing anti-proliferation, anti-migration, and apoptosis-inducing activity in cancer cells.

For research use only. We do not sell to patients.

Purity: 98.69%
CAS No.: 72-80-0
Formula: C₁₀H₇Cl₂NO
Molecular Weight:228.08

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Chlorquinaldol Chemical Structure

CAS No.: 72-80-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Publications (6)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All Antibiotic Isoforms :

In Vitro

Chlorquinaldol (Chloquinan; 5, 10 μM; 24 h) inhibits Wnt/β-catenin signaling by disrupting β-catenin/TCF4 complex in colorectal cancer (CRC) cell^[2].
Chlorquinaldol (5, 10 μM; 24 h) inhibits β-catenin acetylation in CRC cells, thereby reducing the interaction of β-catenin with TCF4^[2].
Chlorquinaldol (0.5, 1, 2 μM; 24 h) inhibits the stemness of CRC cells and exerts anti-CRC activity in vitro and in vivo^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[2]

Cell Line:

SW480, HCT116, HT29 and DLD1 cells
Concentration:

5, 10 μM
Incubation Time:

24 h
Result:

Decreased the mRNA levels of these target genes in all four CRC cell lines in a dose-dependent manner.

Chemical Information

CAS No. 72-80-0
Appearance Solid
Molecular Weight 228.08
Formula C₁₀H₇Cl₂NO
Color Light yellow to brown
SMILES

OC1=C2N=C(C)C=CC2=C(Cl)C=C1Cl
Synonyms

Chloquinan
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (6)

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Journal Impact Factor

ACS Cent Sci

Chlorquinaldol Alleviates Lung Fibrosis in Mice by Inhibiting Fibroblast Activation through Targeting Methionine Synthase Reductase. [Abstract]

2024 Aug 28;10(9):1789-1802. PMID: 39345816
Mol Med

Extinguishing the flames of inflammation: retardant effect of chlorquinaldol on NLRP3-driven diseases. [Abstract]

2024 Dec 19;30(1):245. PMID: 39701924
Clin Transl Med

Loss of LncRNA DUXAP8 synergistically enhanced sorafenib induced ferroptosis in hepatocellular carcinoma via SLC7A11 de-palmitoylation. [Abstract]

2023 Jun;13(6):e1300. PMID: 37337470
Anal Chem

Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]

2025 Jun 3;97(21):11099-11109. PMID: 40401576
Front Microbiol

In vitro Antimicrobial Activity of Chlorquinaldol against Microorganisms Responsible for Skin and Soft Tissue Infections: Comparative Evaluation with Gentamicin and Fusidic Acid. [Abstract]

2017 Jun 8:8:1039. PMID: 28642751
Infect Drug Resist

Chlorquinaldol, a topical agent for skin and wound infections: anti-biofilm activity and biofilm-related antimicrobial cross-resistance. [Abstract]

2019 Jul 19:12:2177-2189. PMID: 31410037

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (219.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.3845 mL

21.9223 mL

43.8446 mL

5 mM

0.8769 mL

4.3845 mL

8.7689 mL

10 mM

0.4384 mL

2.1922 mL

4.3845 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (9.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (9.12 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bortolin M, et al. In vitro Antimicrobial Activity of Chlorquinaldol against Microorganisms Responsible for Skin and Soft Tissue Infections: Comparative Evaluation with Gentamicin and Fusidic Acid. Front Microbiol. 2017 Jun 8;8:1039. [Content Brief]

[2]. Wang L, et al. Chlorquinaldol targets the β-catenin and T-cell factor 4 complex and exerts anti-colorectal cancer activity. Pharmacol Res. 2020 Sep;159:104955. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.3845 mL	21.9223 mL	43.8446 mL	109.6116 mL
	5 mM	0.8769 mL	4.3845 mL	8.7689 mL	21.9223 mL
	10 mM	0.4384 mL	2.1922 mL	4.3845 mL	10.9612 mL
	15 mM	0.2923 mL	1.4615 mL	2.9230 mL	7.3074 mL
	20 mM	0.2192 mL	1.0961 mL	2.1922 mL	5.4806 mL
	25 mM	0.1754 mL	0.8769 mL	1.7538 mL	4.3845 mL
	30 mM	0.1461 mL	0.7307 mL	1.4615 mL	3.6537 mL
	40 mM	0.1096 mL	0.5481 mL	1.0961 mL	2.7403 mL
	50 mM	0.0877 mL	0.4384 mL	0.8769 mL	2.1922 mL
	60 mM	0.0731 mL	0.3654 mL	0.7307 mL	1.8269 mL
	80 mM	0.0548 mL	0.2740 mL	0.5481 mL	1.3701 mL
	100 mM	0.0438 mL	0.2192 mL	0.4384 mL	1.0961 mL

Keywords

Chlorquinaldol

6 Cited Publications

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Chlorquinaldol

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Publications Citing Use of MedChemExpress (MCE) Chlorquinaldol

All Antibiotic Isoforms

Biological Activity

Chemical Information

Publications (6)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Chlorquinaldol Related Classifications

HY-B1360 Related Classifications