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Cat. No.: HY-122101

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NSC114792

NSC114792 is a selective JAK3 inhibitor. NSC114792 induces apoptosis. NSC114792 decreases the protein expression of p-JAK3 and p-STAT5.

For research use only. We do not sell to patients.

CAS No.: 17392-79-9
Formula: C₂₆H₃₂N₄O₂S
Molecular Weight:464.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

NSC114792 Chemical Structure

CAS No.: 17392-79-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Classifications
Bioz

Biological Activity

Description

NSC114792 is a selective JAK3 inhibitor. NSC114792 induces apoptosis. NSC114792 decreases the protein expression of p-JAK3 and p-STAT5^[1].

IC₅₀ & Target^[1]

JAK3

All JAK Isoforms :

In Vitro

NSC114792 (0, 5, 10, 20 µM; 24, 48, 72 h) inhibits BaF3-JAK3^V674A and BKO84 cell viability in a time and dose-dependent manner^[1].
NSC114792 (0, 5, 10, 20 µM) decreases the protein expression of p-JAK3 and p-STAT5 in a dose-dependent manner^[1].
NSC114792 (0, 5, 10, 20 µM; 72 h) induces apoptosis in a dose-dependent manner in L540 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

L540, HDLM-2, MDA-MB-468, DU145 cells
Concentration:

0, 5, 10, 20 µM
Incubation Time:

0, 24, 48, 72 h
Result:

Inhibited cell viability in a time and dose-dependent manner.

Western Blot Analysis^[1]

Cell Line:

BKO84 cells
Concentration:

0, 5, 10, 20 µM
Incubation Time:
Result:

Decreased the protein expression of p-JAK3 and p-STAT5 in a dose-dependent manner.

Apoptosis Analysis^[1]

Cell Line:

L540 cells
Concentration:

0, 10, 20 µM
Incubation Time:

72 h
Result:

Induced apoptosis and increased the expression of cleaved PARP and cleaved Capase-3, decreased the protein expression of Bcl-2, Bcl-Xl, Mcl-1, Survivin in a dose-dependent manner.

Chemical Information

CAS No. 17392-79-9
Molecular Weight 464.62
Formula C₂₆H₃₂N₄O₂S
SMILES

C[C@@]12[C@@H](C(CN3C=NC4=C3N=CNC4=S)=O)CC[C@@]1([H])[C@]5([H])CCC6=CC(CC[C@]6(C)[C@@]5([H])CC2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Kim BH, et al. NSC114792, a novel small molecule identified through structure-based computational database screening, selectively inhibits JAK3. Mol Cancer. 2010 Feb 11;9:36. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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NSC114792

All JAK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NSC114792 Related Classifications

HY-122101 Related Classifications