Indole-3-carbinol-d2
Based on 1 Customer Validation
Indole-3-carbinol-d2 (Indole-3-methanol-d2) is the deuterated-labeled Indole-3-carbinol (HY-N0170). Indole-3-carbinol inhibits NF-κB activity and also is an Aryl hydrocarbon receptor (AhR) agonist, and an inhibitor of WWP1 (WW domain-containing ubiquitin E3 ligase 1).
For research use only. We do not sell to patients.
- Formula: C9H7D2NO
- Molecular Weight:149.19
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
Description
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NF-κB |
AhR |
Human Endogenous Metabolite |
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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Unlabeled CAS 700-06-1
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Appearance Solid
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Molecular Weight 149.19
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Formula C9H7D2NO
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SMILES
OC([2H])([2H])C1=CNC2=C1C=CC=C2
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Synonyms
Indole-3-methanol-d2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Purity & Documentation
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Data Sheet (288 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Mohammadi S, et al. Indole-3-carbinol induces G1 cell cycle arrest and apoptosis through aryl hydrocarbon receptor in THP-1 monocytic cell line.J Recept Signal Transduct Res. 2017 Oct;37(5):506-514. [Content Brief]
[2]. Safa M, et al. Indole-3-carbinol suppresses NF-κB activity and stimulates the p53 pathway in pre-B acute lymphoblastic leukemia cells. Tumour Biol. 2015 May;36(5):3919-30. [Content Brief]
[3]. Lee YR, et al. Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 2019 May 17;364(6441). pii: eaau0159. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Indole-3-carbinol-d2 Related Classifications
HY-N0170S Related Classifications
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Keywords
- Indole-3-carbinol-d2
- Indole-3-methanol-d2
- Isotope-Labeled Compounds
- NF-κB
- Aryl Hydrocarbon Receptor
- E1/E2/E3 Enzyme
- Endogenous Metabolite
- Nuclear factor-κB
- Nuclear factor-kappaB
- AhR
- E1 activating enzyme
- E2 conjugating enzyme
- E3 ligating enzyme
- Ubiquitin activating enzyme
- Ubiquitin conjugating enzyme
- Ubiquitin ligase
- Inhibitor
- inhibitor
- inhibit