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Cat. No.: HY-158434

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IRAK1-IN-1

IRAK1-IN-1 (compound B8) is an orally active IRAK1 inhibitor. IRAK1-IN-1 inhibits the release of IL-6 with the IC₅₀ values of 4.57 μM and 6.51 μM on mouse cells J774A. 1 and human cells THP-1, respectively. IRAK1-IN-1 alleviats LPS (HY-D1056)-induced acute lung injury (ALI) and DSS(HY-116282C)-induced colitis in mice.

For research use only. We do not sell to patients.

CAS No.: 3047343-70-1
Formula: C₁₇H₂₀N₂O₄
Molecular Weight:316.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

IRAK1-IN-1 Chemical Structure

CAS No.: 3047343-70-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All IRAK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
J774.A1	IC₅₀	4.57 μM Compound: B8	Antiinflammatory activity in LPS-induced mouse J774.A1 cells assessed as inhibition of IL-6 production pretreated for 30 mins followed by LPS stimulation and measured after 24 hrs by ELISA Antiinflammatory activity in LPS-induced mouse J774.A1 cells assessed as inhibition of IL-6 production pretreated for 30 mins followed by LPS stimulation and measured after 24 hrs by ELISA	[PMID: 38759452]
THP-1	IC₅₀	6.51 μM Compound: B8	Antiinflammatory activity in LPS-induced human THP-1 cells assessed as inhibition of IL-6 production pretreated for 30 mins followed by LPS stimulation and measured after 24 hrs by ELISA Antiinflammatory activity in LPS-induced human THP-1 cells assessed as inhibition of IL-6 production pretreated for 30 mins followed by LPS stimulation and measured after 24 hrs by ELISA	[PMID: 38759452]

Chemical Information

CAS No. 3047343-70-1
Molecular Weight 316.35
Formula C₁₇H₂₀N₂O₄
SMILES

CC(N1CCN(CC1)CCOC2=CC(OC3=CC=CC=C23)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li X, et al. Design, synthesis and bioactivity evaluation of 4-hydroxycoumarin derivatives as potential anti-inflammatory agents against acute lung injury and colitis. Eur J Med Chem. 2024;272:116487. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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