CH7233163
Based on 1 Customer Validation
CH7233163 is a noncovalent ATP-competitive inhibitor for EGFR-Del19/T790M/C797S. CH7233163 can overcome Osimertinib (HY-15772)-Resistant EGFR-Del19/T790M/C797S mutation. CH7233163 blocks the EGFR phosphorylation in the Del19/T790M/C797S_NIH3T3 cells. CH7233163 has antitumor activities.
For research use only. We do not sell to patients.
- Purity: 99.41%
- CAS No.: 2923365-71-1
- Formula: C31H34F3N9O3S
- Molecular Weight:669.72
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All EGFR Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
1200 nM
Compound: 37; CH7233163
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Antiproliferative activity against human A-431 cells harboring Del19/T790M/C797S mutant assessed as reduction in cell growth
Antiproliferative activity against human A-431 cells harboring Del19/T790M/C797S mutant assessed as reduction in cell growth
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[PMID: 36417820] |
| A-431 | IC50 |
1200 nM
Compound: 37; CH7233163
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Cytotoxicity against human A-431 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 96 hrs by CellTiter-Glo assay
Cytotoxicity against human A-431 cells expressing wild type EGFR assessed as reduction in cell viability incubated for 96 hrs by CellTiter-Glo assay
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[PMID: 36417820] |
| NIH3T3 | IC50 |
20 nM
Compound: 37; CH7233163
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Antiproliferative activity against mouse NIH3T3 cells expressing EGFR Del19/T790M/C797S mutant assessed as reduction in cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against mouse NIH3T3 cells expressing EGFR Del19/T790M/C797S mutant assessed as reduction in cell proliferation incubated for 72 hrs by MTT assay
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[PMID: 36417820] |
Chemical Information
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CAS No. 2923365-71-1
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Appearance Solid
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Molecular Weight 669.72
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Formula C31H34F3N9O3S
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Color Off-white to light yellow
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SMILES
CN(CC1)CCN1C2=CC3=C(C(OCC(F)(F)F)=C2)C4=CN=C(NC5=CC=NC(C6=CN(S(=O)(C7CC7)=O)N=C6)=N5)C=C4N3C(C)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (149.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.73 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4932 mL | 7.4658 mL | 14.9316 mL | 37.3290 mL |
| 5 mM | 0.2986 mL | 1.4932 mL | 2.9863 mL | 7.4658 mL | |
| 10 mM | 0.1493 mL | 0.7466 mL | 1.4932 mL | 3.7329 mL | |
| 15 mM | 0.0995 mL | 0.4977 mL | 0.9954 mL | 2.4886 mL | |
| 20 mM | 0.0747 mL | 0.3733 mL | 0.7466 mL | 1.8665 mL | |
| 25 mM | 0.0597 mL | 0.2986 mL | 0.5973 mL | 1.4932 mL | |
| 30 mM | 0.0498 mL | 0.2489 mL | 0.4977 mL | 1.2443 mL | |
| 40 mM | 0.0373 mL | 0.1866 mL | 0.3733 mL | 0.9332 mL | |
| 50 mM | 0.0299 mL | 0.1493 mL | 0.2986 mL | 0.7466 mL | |
| 60 mM | 0.0249 mL | 0.1244 mL | 0.2489 mL | 0.6222 mL | |
| 80 mM | 0.0187 mL | 0.0933 mL | 0.1866 mL | 0.4666 mL | |
| 100 mM | 0.0149 mL | 0.0747 mL | 0.1493 mL | 0.3733 mL |
CH7233163 Related Classifications
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