FM-479
Based on 1 Customer Validation
FM-479 is the negative control of FM-381 (HY-102046) and has no activity on JAK3 or other kinases. FM-381 is a potent covalent reversible inhibitor of JAK3 targeting the unique Cys909. FM-381 has an IC50 of 127 pM for JAK3, with 410, 2700 and 3600-fold selectivity over JAK1, JAK2 and TYK2, respectively.
For research use only. We do not sell to patients.
- Purity: 99.2%
- CAS No.: 2226521-64-6
- Formula: C25H26N6O2
- Molecular Weight:442.51
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
Biological Activity
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JAK3 |
FM-479 is the inactive control of FM-381, the concentration used in assays is similar[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2226521-64-6
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Appearance Solid
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Molecular Weight 442.51
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Formula C25H26N6O2
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Color Light yellow to yellow
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SMILES
O=C(N(C)C)/C(C#N)=C/C1=CC=C(C2=NC3=CN=C(N(C)C=C4)C4=C3N2C5CCCCC5)O1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)