JAK-IN-33 

JAK-IN-33 (compound 3 (R)) is a JAK inhibitor^[1].

JAK-IN-33 can be effectively applied in blood^[1].
JAK-IN-33 (59 μM, 40 h) can significantly reduce the elevation of GSVA (gene set variation analysis) score stimulated by IL4/IL3 in the human skin, making GSVA score more normal^[1].
JAK-IN-33 (59 μM, 40 h) has acceptable stability in the human skin, and can be effectively applied in human skin^[1].
JAK-IN-33 (0.324 μL, 40 h) significantly inhibits the expression of TARC and two AD (atopic dermatitis) relevant biomarkers MMP12 and Eotaxin 3 in the Franz cells^[1].
JAK-IN-33 is rapidly inactivated in the liver and is expected to have a better targeted systemic safety profile after topical application compares to oral JAK inhibitors repurposed for topical ues.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

465.50

C₂₄H₂₇N₅O₅

3032404-49-9

COC[C@H](OC(CC1=CC=C(N=C1)NC2=CC(NC3=CC=CC=C3OC)=C(C=N2)C(N)=O)=O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Thoma G, Decoret O, et al. Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood. J Med Chem. 2023;66(21):15042-15053.  [Content Brief]