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Cat. No.: HY-157011

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JAK-IN-33

JAK-IN-33 (compound 3 (R)) is a JAK inhibitor.

For research use only. We do not sell to patients.

CAS No.: 3032404-49-9
Formula: C₂₄H₂₇N₅O₅
Molecular Weight:465.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

JAK-IN-33 Chemical Structure

CAS No.: 3032404-49-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

JAK-IN-33 (compound 3 (R)) is a JAK inhibitor^[1].

All JAK Isoforms :

In Vitro

JAK-IN-33 can be effectively applied in blood^[1].
JAK-IN-33 (59 μM, 40 h) can significantly reduce the elevation of GSVA (gene set variation analysis) score stimulated by IL4/IL3 in the human skin, making GSVA score more normal^[1].
JAK-IN-33 (59 μM, 40 h) has acceptable stability in the human skin, and can be effectively applied in human skin^[1].
JAK-IN-33 (0.324 μL, 40 h) significantly inhibits the expression of TARC and two AD (atopic dermatitis) relevant biomarkers MMP12 and Eotaxin 3 in the Franz cells^[1].
JAK-IN-33 is rapidly inactivated in the liver and is expected to have a better targeted systemic safety profile after topical application compares to oral JAK inhibitors repurposed for topical ues.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Real Time qPCR^[1]

Cell Line:

Franz
Concentration:

0.324 μL
Incubation Time:

40 h
Result:

Significantly inhibited the expression of TARC, MMP12 and Eotaxin 3.

Chemical Information

CAS No. 3032404-49-9
Molecular Weight 465.50
Formula C₂₄H₂₇N₅O₅
SMILES

COC[C@H](OC(CC1=CC=C(N=C1)NC2=CC(NC3=CC=CC=C3OC)=C(C=N2)C(N)=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Thoma G, Decoret O, et al. Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood. J Med Chem. 2023;66(21):15042-15053. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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JAK-IN-33

All JAK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JAK-IN-33 Related Classifications

HY-157011 Related Classifications