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Cat. No.: HY-100759

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JAK2-IN-4

JAK2-IN-4 (compound 16h) is a selective JAK2/JAK3 inhibitor, with IC₅₀ values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.

For research use only. We do not sell to patients.

CAS No.: 1438284-00-4
Formula: C₂₃H₂₇N₅O₄S
Molecular Weight:469.56

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

JAK2-IN-4 Chemical Structure

CAS No.: 1438284-00-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

JAK2-IN-4 (compound 16h) is a selective JAK2/JAK3 inhibitor, with IC₅₀ values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively^[1].

IC₅₀ & Target

IC50: 0.7 nM/23.2 nM (JAK2/JAK3)^[1].

All JAK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEL	IC₅₀	1254 nM Compound: 16h	Inhibition of JAK2 V617F mutant in human HEL cells after 1 hr Inhibition of JAK2 V617F mutant in human HEL cells after 1 hr	[PMID: 27771180]
TF-1	IC₅₀	425.6 nM Compound: 16h	Inhibition of JAK2 in human TF1 cells assessed as suppression of cell growth Inhibition of JAK2 in human TF1 cells assessed as suppression of cell growth	[PMID: 27771180]

Chemical Information

CAS No. 1438284-00-4
Molecular Weight 469.56
Formula C₂₃H₂₇N₅O₄S
SMILES

CC(C=NC(NC1=CC=C(N2CCOCC2)C=C1)=N3)=C3C(O4)=CC5=C4CCN(S(=O)(C)=O)C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wang Y, et al. Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors. Bioorg Med Chem. 2017 Jan 1;25(1):75-83. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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JAK2-IN-4

All JAK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

JAK2-IN-4 Related Classifications

HY-100759 Related Classifications