JAK2-IN-4
JAK2-IN-4 (compound 16h) is a selective JAK2/JAK3 inhibitor, with IC50 values of 0.7 nM and 23.2 nM for JAK2 and JAK3, respectively.
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- CAS. Nr.: 1438284-00-4
- Formel: C23H27N5O4S
- Molecular Weight:469.56
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
IC50: 0.7 nM/23.2 nM (JAK2/JAK3)[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEL | IC50 |
1254 nM
Compound: 16h
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Inhibition of JAK2 V617F mutant in human HEL cells after 1 hr
Inhibition of JAK2 V617F mutant in human HEL cells after 1 hr
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[PMID: 27771180] |
| TF-1 | IC50 |
425.6 nM
Compound: 16h
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Inhibition of JAK2 in human TF1 cells assessed as suppression of cell growth
Inhibition of JAK2 in human TF1 cells assessed as suppression of cell growth
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[PMID: 27771180] |
Chemical Information
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CAS. Nr. 1438284-00-4
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Molecular Weight 469.56
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Formel C23H27N5O4S
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SMILES
CC(C=NC(NC1=CC=C(N2CCOCC2)C=C1)=N3)=C3C(O4)=CC5=C4CCN(S(=O)(C)=O)C5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
JAK2-IN-4 Related Classifications
HY-100759 Related Classifications
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