Cearoin
Based on 1 Customer Validation
Cearoin increases autophagy and apoptosis through the production of ROS and the activation of ERK.
For research use only. We do not sell to patients.
- Purity : 99.09%
- CAS No.: 52811-37-7
- Formula: C14H12O4
- Molecular Weight:244.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
ERK |
ROS |
Autophagy |
Apoptosis |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
>10 μg/mL
Compound: 4
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Cytotoxicity against human A549 cells
Cytotoxicity against human A549 cells
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[PMID: 21784631] |
| DU-145 | IC50 |
>10 μg/mL
Compound: 4
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Cytotoxicity against human DU145 cells
Cytotoxicity against human DU145 cells
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[PMID: 21784631] |
| J774.1 | IC50 |
15.4 μM
Compound: 13
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Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay
Inhibition of LPS-induced NO production in mouse J774.1 cells after 24 hrs by Griess reagent assay
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[PMID: 15974608] |
| KB | IC50 |
35.33 μM
Compound: 4
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Cytotoxicity against human KB cells
Cytotoxicity against human KB cells
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[PMID: 21784631] |
In Vitro
Cearoin (10-80 μM) induces cell death in a dose-dependent manner[1].
Cearoin (10-80 μM) increases the phosporylation of ERK in SH-SY5Y cells[1].
Cearoin (5-80 μM) increases the conversion of LC3B-I to LC3B-II in SH-SY5Y cells. The expression of LC3B-II is a good marker for autophagosome formation in the autophagy process[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human neuroblastoma SH-SY5Y cells
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Concentration:0, 1, 5, 10, 20, 40, or 80 μM
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Incubation Time:6 or 12 hours
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Result:Significantly decreased cell viability from 10 μM in a dose-dependent manner. Treatment with 40 μM for 12 h induced about 50% loss in cell viability in SH-SY5Y cells.
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Cell Line:Human neuroblastoma SH-SY5Y cells
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Concentration:0, 5, 10, 20, 40, or 80 μM
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Incubation Time:12 hours
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Result:Increased ERK phosphorylation in a dose-dependent manner, whereas it did not alter JNK phosphorylation.
Induced the formation of LC3B-II in a dose dependent manner.
Chemical Information
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CAS No. 52811-37-7
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Appearance Solid
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Molecular Weight 244.24
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Formula C14H12O4
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Color Light yellow to green yellow
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SMILES
O=C(C1=CC(O)=C(OC)C=C1O)C2=CC=CC=C2
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (204.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0943 mL | 20.4717 mL | 40.9433 mL | 102.3583 mL |
| 5 mM | 0.8189 mL | 4.0943 mL | 8.1887 mL | 20.4717 mL | |
| 10 mM | 0.4094 mL | 2.0472 mL | 4.0943 mL | 10.2358 mL | |
| 15 mM | 0.2730 mL | 1.3648 mL | 2.7296 mL | 6.8239 mL | |
| 20 mM | 0.2047 mL | 1.0236 mL | 2.0472 mL | 5.1179 mL | |
| 25 mM | 0.1638 mL | 0.8189 mL | 1.6377 mL | 4.0943 mL | |
| 30 mM | 0.1365 mL | 0.6824 mL | 1.3648 mL | 3.4119 mL | |
| 40 mM | 0.1024 mL | 0.5118 mL | 1.0236 mL | 2.5590 mL | |
| 50 mM | 0.0819 mL | 0.4094 mL | 0.8189 mL | 2.0472 mL | |
| 60 mM | 0.0682 mL | 0.3412 mL | 0.6824 mL | 1.7060 mL | |
| 80 mM | 0.0512 mL | 0.2559 mL | 0.5118 mL | 1.2795 mL | |
| 100 mM | 0.0409 mL | 0.2047 mL | 0.4094 mL | 1.0236 mL |
Cearoin Related Classifications
HY-N8418 Related Classifications
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