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Cat. No.: HY-160991

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Menabitan

(Synonyms: SP-204)

Menabitan (SP-204) is an inhibitor for phosphodiesterase 9 (PDE 9), which acts as a non-opioid analgesic agent. Menabitan lowers the intraocular pressure in rabbit model.

For research use only. We do not sell to patients.

CAS No.: 83784-21-8
Formula: C₃₇H₅₆N₂O₃
Molecular Weight:576.85

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Menabitan Chemical Structure

CAS No.: 83784-21-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Menabitan (SP-204) is an inhibitor for phosphodiesterase 9 (PDE 9), which acts as a non-opioid analgesic agent. Menabitan lowers the intraocular pressure in rabbit model^[1].

IC₅₀ & Target

PDE9

All Phosphodiesterase (PDE) Isoforms :

Chemical Information

CAS No. 83784-21-8
Molecular Weight 576.85
Formula C₃₇H₅₆N₂O₃
SMILES

O=C(C(CCN1CCCCC1C)C)OC2=CC(C(C(CCCCC)C)C)=CC3=C2C(CN(CC4)CC#C)=C4C(C)(C)O3
Synonyms

SP-204
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Anaebonam A O. Analytical, formulation development and stability testing of a lyophilized dosage form of menabitan hydrochloride, a new potent analgesic[M]. Massachusetts College of Pharmacy and Health Sciences, 1986.

[2]. PITTENGER C, et al., Enhancement of the efficacy of serotonergic psychedelic drugs in the treatment or prevention of certain neuropsychiatric disorders through inhibition of type-9 phosphodiesterases. WO2024107445.

[3]. Green K, et al., Acute dose response of intraocular pressure to topical and oral cannabinoids. Proc Soc Exp Biol Med. 1977 Feb;154(2):228-31. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Menabitan

All Phosphodiesterase (PDE) Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Menabitan Related Classifications

HY-160991 Related Classifications