Elpipodect
Based on 1 Customer Validation
Elpipodect (MK-8189) is an orally active and selective PDE10A inhibitor with a Ki value of 29 pM. Elpipodect can be used in research of schizophrenia.
For research use only. We do not sell to patients.
- Purity: 98.95%
- CAS No.: 1424371-93-6
- Formula: C19H22N6OS
- Molecular Weight:382.48
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Metabolism/Protease Compound Library
HY-L012
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Clinical Compound Library
HY-L026
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Drug Repurposing Compound Library
HY-L035
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Orally Active Compound Library
HY-L061
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Anti-Alzheimer's Disease Compound Library
HY-L069
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Neurodegenerative Disease-related Compound Library
HY-L086
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Anti-Colorectal Cancer Compound Library
HY-L103
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Metabolic Enzyme Compound Library
HY-L146
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Highly Selective Inhibitors Library
HY-L158
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Drug Repurposing Compound Library Plus
HY-L035P
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Clinical Compound Library Plus
HY-L026P
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
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PDE10A 29 pM (Ki) |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar-Hannover rats[1]
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Dosage:0.25, 0.5, and 0.75 mg/kg
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Administration:Oral administration
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Result:Improved identification ability relative to the vector handling animal.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1424371-93-6
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Appearance Solid
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Molecular Weight 382.48
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Formula C19H22N6OS
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Color Off-white to light yellow
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SMILES
CC(S1)=NN=C1CNC2=CC(OC[C@@H]3[C@@H](C4=CC=C(C=N4)C)C3)=NC(C)=N2
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Synonyms
MK-8189
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 125 mg/mL (326.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6145 mL | 13.0726 mL | 26.1452 mL | 65.3629 mL |
| 5 mM | 0.5229 mL | 2.6145 mL | 5.2290 mL | 13.0726 mL | |
| 10 mM | 0.2615 mL | 1.3073 mL | 2.6145 mL | 6.5363 mL | |
| 15 mM | 0.1743 mL | 0.8715 mL | 1.7430 mL | 4.3575 mL | |
| 20 mM | 0.1307 mL | 0.6536 mL | 1.3073 mL | 3.2681 mL | |
| 25 mM | 0.1046 mL | 0.5229 mL | 1.0458 mL | 2.6145 mL | |
| 30 mM | 0.0872 mL | 0.4358 mL | 0.8715 mL | 2.1788 mL | |
| 40 mM | 0.0654 mL | 0.3268 mL | 0.6536 mL | 1.6341 mL | |
| 50 mM | 0.0523 mL | 0.2615 mL | 0.5229 mL | 1.3073 mL | |
| 60 mM | 0.0436 mL | 0.2179 mL | 0.4358 mL | 1.0894 mL | |
| 80 mM | 0.0327 mL | 0.1634 mL | 0.3268 mL | 0.8170 mL | |
| 100 mM | 0.0261 mL | 0.1307 mL | 0.2615 mL | 0.6536 mL |
Elpipodect Related Classifications
HY-153093 Related Classifications
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