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Cat. No.: HY-N19136

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SB87-Cl

SB87-Cl is a halogenated benzophenone antibiotic that can be isolated from fungi of the genus Pestalotiopsis. SB87-Cl exhibits strong antibacterial activity against Gram-positive bacteria, but is accompanied by cytotoxicity to mammalian cells. SB87-Cl can be used in studies of Staphylococcus aureus infection, methicillin (Methicillin (HY-121544))-resistant Staphylococcus aureus (MRSA) infection, and vancomycin (Vancomycin (HY-B0671))-susceptible Enterococcus faecium (VSE) infection.

For research use only. We do not sell to patients.

CAS No.: 163768-83-0
Formula: C₂₀H₁₈Cl₂O₆
Molecular Weight:425.26

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SB87-Cl Chemical Structure

CAS No.: 163768-83-0

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

All Antibiotic Isoforms :

In Vitro

SB87-Cl (0.31-10 μg/mL; 6-8 h) exhibits antibacterial activity against Staphylococcus aureus (MIC = 2.5 μg/mL), methicillin-resistant Staphylococcus aureus (MIC = 2.5 μg/mL), and vancomycin-sensitive Enterococcus faecium (MIC = 1.25 μg/mL), but shows no inhibitory effect on vancomycin-resistant Enterococcus faecium even at concentrations up to 10 μg/mL^[1].
SB87-Cl (0.016-50 μM) exhibits cytotoxicity against A549, HeLa, HepG2, MCF-7 and Vero cells, with IC₅₀ values of 2.9, 2.1, 3.9, 4.6 and 2.4 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 163768-83-0
Molecular Weight 425.26
Formula C₂₀H₁₈Cl₂O₆
SMILES

O=CC1=C(C=C(C(C/C=C(C)\C)=C1C(C2=C(C(Cl)=C(C)C(Cl)=C2O)O)=O)O)O
Structure Classification
- Phenols
- Polyphenols
Initial Source
- Microorganisms
Chrysosporium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jiang Z, et al. Pestalotinones A-D, new benzophenone antibiotics from endophytic fungus Pestalotiopsis trachicarpicola SC-J551. The Journal of antibiotics. 2022 Apr;75(4):207-212. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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SB87-Cl

All Antibiotic Isoforms