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Cat. No.: HY-174430

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WWQ-131

WWQ-131 is a potent selective JAK2 inhibitor with an IC₅₀ of 2.56 nM. WWQ-131 shows >252-fold selectivity over JAK1, JAK3, and TYK2. WWQ-131 exhibits antiproliferative activity against cancer cells. WWQ-131 is the ligand for target protein for PROTAC JAK2 degrader-1 (HY-174428). WWQ-131 can be used for the research of myeloproliferative neoplasms (MPNs).

For research use only. We do not sell to patients.

CAS No.: 1558007-80-9
Formula: C₂₁H₂₃ClFN₅O
Molecular Weight:415.89

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

WWQ-131 Chemical Structure

CAS No.: 1558007-80-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

JAK2

2.56 nM (IC₅₀)

JAK1

647.35 nM (IC₅₀)

JAK3

528.61 nM (IC₅₀)

Tyk2

1298.13 nM (IC₅₀)

All JAK Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
NIH3T3	IC₅₀	387 nM Compound: 1a	Inhibition of human EML4-fused ALK L1196M mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISA Inhibition of human EML4-fused ALK L1196M mutant expressed in mouse NIH-3T3 cells assessed as phospho-ALK level after 1 hr by sandwich ELISA	[PMID: 24432909]

In Vitro

WWQ-131 inhibits the proliferation of SET-2 and HEL cells with IC₅₀ values of 1.15 and 2.36 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1558007-80-9
Molecular Weight 415.89
Formula C₂₁H₂₃ClFN₅O
SMILES

FC1=CC([C@H](OC2=C(N=CC(C3=CN(N=C3)C4CCNCC4)=C2)N)C)=C(C=C1)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang C, et al. Discovery of a Proteolysis-Targeting Chimera Degrader of JAK2 as a Potential Therapeutic Agent for JAK2-Mediated Myeloproliferative Neoplasms. J Med Chem. 2025;68(11):12085-12099. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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WWQ-131

All JAK Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

WWQ-131 Related Classifications

HY-174430 Related Classifications