製品番号: HY-B0891

17α-ヒドロキシプロゲステロン

(別名: 17-OHP; 17α-Hydroxyprogesterone; 17-Hydroxyprogesterone)

4 Cited Publications

カスタマーレビュー

Based on 4 publication(s) in Google Scholar

17α-Hydroxyprogesterone is a steroid hormone. 17α-Hydroxyprogesterone induces ovarian growth and yolk production in female crabs and increases blood pressure in sheep. 17α-Hydroxyprogesterone is mainly used in research related to crustacean reproduction and animal hypertension.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.63%
CAS 番号: 68-96-2
分子式: C₂₁H₃₀O₃
分子量:330.46

保管条件:

4°C, protect from light

* In solvent : -80°C, 2 years; -20°C, 1 year (protect from light)

17α-Hydroxyprogesterone 構造式

CAS 番号: 68-96-2

容量

価格（税別）

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数量

Sample (0.1mg)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

Human Endogenous Metabolite

Endogenous Metabolite アイソフォーム固有の製品をすべて表示 :

体内実験

17α-Hydroxyprogesterone (10-100 nmol/crab; injection; injection on days 1, 7, 14, 21 and 28; administration cycle 28 days) significantly increased the mean oocyte diameter, mean ovarian index and ovarian vitellogenin content in female crabs (Oziotelphusa senex senex)^[1].
17α-Hydroxyprogesterone (1 mg/h; 5 days) increased systolic and diastolic blood pressure in sheep^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 68-96-2
性状 Solid
分子量 330.46
分子式 C₂₁H₃₀O₃
Color White to off-white
SMILES

CC([C@@]1(O)CC[C@@]2([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O)=O
別名

17-OHP; 17α-Hydroxyprogesterone; 17-Hydroxyprogesterone
Structure Classification
- Steroids
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light

* In solvent : -80°C, 2 years; -20°C, 1 year (protect from light)

Publications (4)

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Journal Impact Factor

Nat Commun

Coronavirus envelope protein activates TMED10-mediated unconventional secretion of inflammatory factors. [Abstract]

2024 Oct 8;15(1):8708. PMID: 39379362
Nat Chem Biol

Structures of the ADGRG2-Gs complex in apo and ligand-bound forms. [Abstract]

2022 Nov;18(11):1196-1203. PMID: 35982227
Sci Rep

Dynamic change of estrogen and progesterone metabolites in human urine during pregnancy. [Abstract]

2025 Mar 11;15(1):8409. PMID: 40069295
Mol Cell Endocrinol

Extended steroid profiling in H295R cells provides deeper insight into chemical-induced disturbances of steroidogenesis: Exemplified by prochloraz and anabolic steroids. [Abstract]

2023 Jun 15:570:111929. PMID: 37037411

溶剤 & 溶解度

体外:

DMSO : 50 mg/mL (151.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : < 0.1 mg/mL (insoluble)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0261 mL

15.1304 mL

30.2609 mL

5 mM

0.6052 mL

3.0261 mL

6.0522 mL

10 mM

0.3026 mL

1.5130 mL

3.0261 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year (protect from light). When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.57 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.57 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (278 KB)
SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Portuguese - PT (418 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Reddy P R, et al. 17α-Hydroxyprogesterone induced ovarian growth and vitellogenesis in the freshwater rice field crab Oziotelphusa senex senex. Aquaculture, 2006, 254(1-4): 768-775.

[2]. Coghlan J P, et al. Hypertensive effect of 17α, 20α7–dihydroxyprogesterone and 17α-hydroxyprogesterone in the sheep. Nature, 1976, 263(5578): 608-609.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.0261 mL	15.1304 mL	30.2608 mL	75.6521 mL
	5 mM	0.6052 mL	3.0261 mL	6.0522 mL	15.1304 mL
	10 mM	0.3026 mL	1.5130 mL	3.0261 mL	7.5652 mL
	15 mM	0.2017 mL	1.0087 mL	2.0174 mL	5.0435 mL
	20 mM	0.1513 mL	0.7565 mL	1.5130 mL	3.7826 mL
	25 mM	0.1210 mL	0.6052 mL	1.2104 mL	3.0261 mL
	30 mM	0.1009 mL	0.5043 mL	1.0087 mL	2.5217 mL
	40 mM	0.0757 mL	0.3783 mL	0.7565 mL	1.8913 mL
	50 mM	0.0605 mL	0.3026 mL	0.6052 mL	1.5130 mL
	60 mM	0.0504 mL	0.2522 mL	0.5043 mL	1.2609 mL
	80 mM	0.0378 mL	0.1891 mL	0.3783 mL	0.9457 mL
	100 mM	0.0303 mL	0.1513 mL	0.3026 mL	0.7565 mL

Keywords

17α-Hydroxyprogesterone

4 Cited Publications

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17α-ヒドロキシプロゲステロン

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MedChemExpress（MCE）の使用を引用している文献 17α-Hydroxyprogesterone

Endogenous Metabolite アイソフォーム固有の製品をすべて表示

生物活性

化学情報

Publications (4)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

17α-Hydroxyprogesterone 関連分類

製品番号: HY-B0891