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Sotuletinib

(別名: BLZ945)
41 Cited Publications
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Based on 41 publication(s) in Google Scholar

Sotuletinib (BLZ945) is a potent, selective, orally active and brain-penetrant CSF-1R (c-Fms) inhibitor with an IC50 of 1 nM, showing more than 1,000-fold selectivity against its closest receptor tyrosine kinase homologs. Sotuletinib can be used for microglia depletion, and for tumor and CNS-related disease research.

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  • 純度: 99.97%
  • CAS 番号: 953769-46-5
  • 分子式: C20H22N4O3S
  • 分子量:398.48
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months
  • Sotuletinib Chemical Structure
    Sotuletinib 構造式
  • Experimental Validation Results for Sotuletinib
  • Experimental Validation Results for Sotuletinib
  • Experimental Validation Results for Sotuletinib
  • Experimental Validation Results for Sotuletinib
  • Experimental Validation Results for Sotuletinib
  • Experimental Validation Results for Sotuletinib
CAS 番号: 953769-46-5
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In Vivo Efficacy StudyIHCCell Proliferation/Viability AssayApoptosis AnalysisHistological Imaging/Staining
  • Cell Proliferation/Viability Assay
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  • In Vivo Efficacy Study
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  • In Vivo Efficacy Study
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  • Sotuletinib Chemical Structure
    Sotuletinib Chemical Structure
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  • 1/16

    Sotuletinib purchased from MedChemExpress. Usage Cited in: Mol Ther. 2025 Nov 12:S1525-0016(25)00871-8. [Abstract]

    Customer Validation
     Survival curves of WT (black) and G793A (blue) BM macrophages treated for seven days with BLZ945 (Sotuletinib, 0.1-10000 nM).

  • 1/16

    Sotuletinib purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Dec;11(45):e2404756. [Abstract]

    Customer Validation
     Sotuletinib (BLZ945) (200 mg/kg; oral gavage; four times a week for 7 weeks) inhibited the infiltration of F4/80+ macrophages and reduced the expression of the M2 macrophage marker CD206 in DEN-CCl4-induced hepatocellular carcinoma-forming C57BL/6J mice.

  • 1/16

    Sotuletinib purchased from MedChemExpress. Usage Cited in: Bioact Mater. 2022 Mar 11:16:107-119. [Abstract]

    Customer Validation
     Prophylactic nanovaccine have a synergistic effect with BLZ-945 (Sotuletinib, 1 mg/kg; i.t.) and NLG-919 (2 mg/kg; i.t.), which inhibits tumor growth and prolongs survival in tumor-bearing mice.

  • 1/16

    Sotuletinib purchased from MedChemExpress. Usage Cited in: J Exp Med. 2023 Mar 6;220(3):e20220857. [Abstract]

    Customer Validation
     Quantification of iMG cell death by fluorescent Caspase 3/7 Dye for Apoptosis over 24 h in culture with complete medium treated with BLZ945 (Sotuletinib, 250 nM, 500 nM, or 1 µM; 5-20 h).

  • 1/16

    Sotuletinib purchased from MedChemExpress. Usage Cited in: J Exp Med. 2016 Dec 12;213(13):2989-3005. [Abstract]

    Customer Validation
     Graph of percent tumor growth over baseline for 21 d of treatment with or without 200 mg/kg of BLZ945 (Sotuletinib, oral gavage; once daily). *, P < 0.05; **, P < 0.01. n = 5 per group, Student’s t test.

  • 1/16

    Sotuletinib purchased from MedChemExpress. Usage Cited in: J Exp Med. 2016 Dec 12;213(13):2989-3005. [Abstract]

    Customer Validation
     Examples of photomicrographs of control tumors and BLZ945 (Sotuletinib, 200 mg/kg; oral gavage; once daily for 21 days)-treated tumors with corresponding GFP expression demonstrating the twofold increase in control tumor volume. Middle panel is control lungs with grossly visible metastases (arrowheads). Bars: (black) 10 µm; (white) 5 mm.

  • Sotuletinib