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Baloxavir

(別名: Baloxavir acid; S-033447)
49 Cited Publications
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Based on 49 publication(s) in Google Scholar

Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity.

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  • 純度: 99.92%
  • CAS 番号: 1985605-59-1
  • 分子式: C24H19F2N3O4S
  • 分子量:483.49
  • 保管条件:

    4°C, stored under nitrogen

    * In solvent : -80°C, 1 year; -20°C, 6 months (stored under nitrogen)

  • Baloxavir Chemical Structure
    Baloxavir 構造式
  • Experimental Validation Results for Baloxavir
  • Experimental Validation Results for Baloxavir
  • Experimental Validation Results for Baloxavir
  • Experimental Validation Results for Baloxavir
  • Experimental Validation Results for Baloxavir
  • Experimental Validation Results for Baloxavir
CAS 番号: 1985605-59-1
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Cell Proliferation/Viability AssayIHCRT-PCR
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  • Cell Proliferation/Viability Assay
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  • Cell Proliferation/Viability Assay
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  • Baloxavir Chemical Structure
    Baloxavir Chemical Structure
    1/16
  • 1/16

    Baloxavir purchased from MedChemExpress. Usage Cited in: Acta Pharm Sin B. 2025 Aug;15(8):4156-4173. [Abstract]

    Customer Validation
     Baloxavir-resistant WSN strains that had been passaged 40 times in the presence of baloxavir, with an EC50 of 1.04 μmol/L

  • 1/16

    Baloxavir purchased from MedChemExpress. Usage Cited in: Emerg Microbes Infect. 2025 Dec;14(1):2564308. [Abstract]

    Customer Validation
     Susceptibility of influenza D and A viruses to anti-influenza drugs. Drug susceptibility profiles of baloxavir were assessed using a viral yield reduction assay in MDCK cells. Cells were infected with IDV and IAV (MOI = 0.1), followed by removal of the virus inoculum and treatment with serially diluted drugs. Supernatants were collected at designated timepoints post-infection for TCID50 titration. Antiviral activity (%) was calculated relative to virus-free and drug-free controls.

  • 1/16

    Baloxavir purchased from MedChemExpress. Usage Cited in: Front Immunol. 2025 Mar 17:16:1532336. [Abstract]

    Customer Validation
     After infection of MDCK cells with H1N1-UI182 at an MOI of 0.01, the cells were treated with Quercetin (10 µM), Taxifolin (50 µM), Miquelianin (100 µM), and Baloxavir (10 µM) for 48 h. Nuclei were stained with DAPI, and infected cells were detected by NP-specific immunofluorescence staining (scale bar: 100 µm).

  • 1/16

    Baloxavir purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2025 Jun 3;26(11):5358. [Abstract]

    Customer Validation
     B/Jifang/13/97. MDCK cells were infected with IAV or IBV at an MOI of 0.02 for 2 h and then treated with lycorine, Bal (Baloxavir), and OC. AH was added during infection. Total RNA was extracted, and the IAV M2 or IBV HA mRNA levels were quantified using qRT-PCR.

  • 1/16

    Baloxavir purchased from MedChemExpress. Usage Cited in: Influenza Other Respir Viruses. 2025 Oct;19(10):e70176. [Abstract]

    Customer Validation
     Seven strains were selected from a total of 41 seasonal strains that showed high viral activity during oseltamivir treatment. The EC50 was compared to the reference H1N1 (A/Hong Kong/415742/09).

  • 1/16

    Baloxavir purchased from MedChemExpress. Usage Cited in: Front Pharmacol. 2019 Oct 16;10:1203. [Abstract]

    Customer Validation
     Cell viability as a percentage of the control cell (treated with DMSO for T-705 or PBS for BXA) viability in uninfected Vero E6 cells incubated for 72 h post-T-705 (Favipiravir)/BXA (Baloxavir) treatment. Each point represents the mean and SD of three independent experiments.

  • Baloxavir