Bethanechol
Based on 3 publication(s) in Google Scholar
Bethanechol (Carbamyl-β-methylcholine), a parasympathomimetic agent, is a mAChR agonist that exerts its effects via directly stimulating the mAChR (M1, M2, M3, M4, and M5) of the parasympathetic nervous system.
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- CAS 番号: 674-38-4
- 分子式: C7H17N2O2
- 分子量:161.22
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Bethanechol
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生物活性
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mAChR1 |
mAChR3 |
mAChR4 |
mAChR5 |
Bethanechol (0.3-300 μM) significantly reduces ileal pacemaker potentials[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female rats of the Blue Spruce Farms (Sprague-Dawley) (280-330 g) [4]
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Dosage:2 mg/kg, 4 mg/kg, 8 mg/kg, 12 mg/kg
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Administration:Intraperitoneal injection
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Result:Increased water intake during the first hr in a dose-dependent fashion up to the highest dose administered (12 mg/kg).
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 674-38-4
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分子量 161.22
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分子式 C7H17N2O2
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SMILES
CC(OC(N)=O)C[N+](C)(C)C
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別名
Carbamyl-β-methylcholine
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Cell Stem Cell
Vagal pathway activation links chronic stress to decline in intestinal stem cell function. [Abstract]2025 Mar 20:S1934-5909(25)00084-0. PMID: 40120585 -
Acta Pharmacol Sin
Activation of peripheral muscarinic receptors rescues depressive-like behaviors via gut-brain-axis, involving parasympathetic excitation. [Abstract]2026 May 29. PMID: 42215618 -
純度とドキュメンテーション
参考文献
[1]. Inderbir S. Padda, et al. Bethanechol. Treasure Island (FL): StatPearls Publishing; 2020 Jan-.
[2]. Julia Yuen Hang Liu, et al. Acetylcholine exerts inhibitory and excitatory actions on mouse ileal pacemaker activity: role of muscarinic versus nicotinic receptors. Am J Physiol Gastrointest Liver Physiol. 2020 Jul 1;319(1):G97-G107. [Content Brief]
[3]. M J Fregly, et al. Bethanechol-induced water intake in rats: possible mechanisms of induction. Pharmacol Biochem Behav. 1982 Oct;17(4):727-32. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Bethanechol 関連分類
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