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Carbonyl Cyanide m-Chlorophenylhydrazone

(別名: CCCP; Carbonyl cyanide 3-chlorophenylhydrazone; カルボニルシアニド-m-クロロフェニルヒドラゾン)
189 Cited Publications
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Based on 189 publication(s) in Google Scholar

CCCP is an oxidative phosphorylation (OXPHOS) uncoupler. CCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation.

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  • 純度: 98.12%
  • CAS 番号: 555-60-2
  • 分子式: C9H5ClN4
  • 分子量:204.62
  • 保管条件:
    Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 2 years , -20°C, 1 year
  • CCCP Chemical Structure
    CCCP 構造式
  • Experimental Validation Results for CCCP
  • Experimental Validation Results for CCCP
  • Experimental Validation Results for CCCP
  • Experimental Validation Results for CCCP
  • Experimental Validation Results for CCCP
CAS 番号: 555-60-2
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MedChemExpress（MCE）の使用を引用している文献 CCCP

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  • CCCP Chemical Structure
    CCCP Chemical Structure
    1/16
  • 1/16

    CCCP purchased from MedChemExpress. Usage Cited in: ACS Nano. 2025 Jan 14;19(1):1702-1712. [Abstract]

    Customer Validation
     CCCP (10 μM; 4 h) resulted in a more than 10,000-fold decrease in the survival rate of EI cells exposed to AgNPs.

  • 1/16

    CCCP purchased from MedChemExpress. Usage Cited in: Cell Metab. 2023 Jan 3;35(1):200-211.e9. [Abstract]

    Customer Validation
     Carbonyl cyanide 3-chlorophenylhydrazone (CCCP) (10 μM), significantly decreased mitochondrial membrane potential and inhibited lactate enrichment in isolated mitochondria upon lactate incubation

  • 1/16

    CCCP purchased from MedChemExpress. Usage Cited in: Nature. 2019 Nov;575(7782):375-379. [Abstract]

    Customer Validation
     Mitochondrial membrane potential assessed by flowcytometry for TMRE is disrupted in CCCP (20 μM) treatment.

  • 1/16

    CCCP purchased from MedChemExpress. Usage Cited in: Nature. 2019 Nov;575(7782):375-379. [Abstract]

    Customer Validation
     PINK1 accumulation in mitochondria is impaired in cells lacking ANT. Cells bearing gRNA targets to the indicated genes were transduced with PINK1-GFP, followed by treatment with CCCP (20 μM) versus control, and then immunostained using anti-Tom20 antibody.

  • 1/16

    CCCP purchased from MedChemExpress. Usage Cited in: Nature. 2019 Nov;575(7782):375-379. [Abstract]

    Customer Validation
     Phosphorylation of PINK1 after CCCP (20 μM) treatment is preserved in the absence of ANT1.

  • CCCP