製品番号: HY-N0784

Ginkgolide B

(別名: ギンコリドB; BN-52021)

13 Cited Publications

カスタマーレビュー

Based on 13 publication(s) in Google Scholar

Ginkgolide B (BN-52021), a terpene lactone, is a potent platelet activating factor antagonist. Ginkgolide B protects endothelial cells via the activation of PXR from injuries induced by xeno- and endobiotics. Ginkgolide B can pass through the brain-blood barrier. Ginkgolide B has anti-oxidant, anti-inflammatory, anti-tumor, and anti-apoptotic activity. Ginkgolide B has marked neuroprotective effects against ischemia-induced impairments.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.84%
CAS 番号: 15291-77-7
分子式: C₂₀H₂₄O₁₀
分子量:424.40

保管条件:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Ginkgolide B 構造式

CAS 番号: 15291-77-7

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Ginkgolide B (BN-52021; 30-150 μM; 24 h) inhibits the up-regulation of VCAM-1 and E-selectin protein expression induced by TNF-α (10 ng/mL)^[1].
Ginkgolide B (30-150 μM; 24, 48 h) increases CYP3A4 mRNA and MDR1 expression^[1].
Ginkgolide B (30-150 μM; pretreated for 24 h) reduces Staurosporine-induced (500 nM; 6 h) apoptosis compared with the positive controls, which exhibited marked apoptosis compared with negative controls. Ginkgolide B does not affect Doxorubicin (5 μM; 24 h) induced apoptosis^[1].
Ginkgolide B regulates PXR activity and does not affect PXR expression^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HUVECs
Concentration:

30, 60, 150 μM
Incubation Time:

24 h
Result:

Inhibited the up-regulation of VCAM-1 and E-selectin protein expression induced by TNF-α.

RT-PCR^[1]

Cell Line:

HUVECs
Concentration:

30, 60, 150 μM
Incubation Time:

24, 48 h
Result:

Increased CYP3A4 mRNA and MDR1 expression after 24 h, and this effect was dose-dependent after 48 h.

体内実験

Ginkgolide B (BN-52021; 20 mg/kg; Intraperitoneally; immediately and 6 hours after ischemia, and thereafter once daily; 14 days) decreases the neurological deficit score^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male clean healthy Sprague-Dawley rats, weighing 250-280 g and aged 8 weeks^[2]
Dosage:

20 mg/kg
Administration:

Intraperitoneally; immediately and 6 hours after ischemia, and thereafter once daily; 14 days
Result:

Decreased the neurological deficit score, increased the proportion of nestin-, neuron-specific enolase- and glial fibrillary acid protein-positive cells.
Caused down-regulation of NSE protein at day 14.

化学情報

CAS 番号 15291-77-7
性状 Solid
分子量 424.40
分子式 C₂₀H₂₄O₁₀
Color White to off-white
SMILES

O[C@@H]1C(C2([C@H]3O)[C@](OC3=O)([H])O4)([C@@](O5)([H])C[C@H]2C(C)(C)C)C4(C5=O)[C@@](O)([C@@H]6C)[C@@]1([H])OC6=O
別名

ギンコリドB; BN-52021
Structure Classification
- Terpenoids
- Diterpenoids
Initial Source
- Endogenous metabolite
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Publications (13)

All WBCell Proliferation/Viability AssayRT-PCRHistological Imaging/StainingIHCIF

Sort by:

Journal Impact Factor

Adv Healthc Mater

Designed Liquid Crystalline Nanoassemblies From Clinically Validated Polyunsaturated Lipids for Combined Antioxidant, Anti-Apoptotic, and Neurotrophic Treatments. [Abstract]

2026 Jun;15(21):e05595. PMID: 41937329
J Agric Food Res

2025 Nov 24.
Neurobiol Dis

Nuclear localization of platelet activating factor receptor accounts for microglial phagocytosis in ischemic stroke. [Abstract]

2025 Sep:213:107020. PMID: 40623479
Int Immunopharmacol

Ginkgolide B attenuates post-stroke cognitive impairment via exosomal miR-299a-3p regulation of the TRIL/PI3K/AKT pathway. [Abstract]

2026 May 1:176:116479. PMID: 41819672
Biofactors

Ginkgolide B and bilobalide promote the growth and increase β-catenin expression in hair follicle dermal papilla cells of American minks. [Abstract]

2019 Nov;45(6):950-958. PMID: 31520488
Neuropharmacology

Ginkgolide B can alleviate spinal cord glymphatic system dysfunction and provide neuroprotection in painful diabetic neuropathy rats by inhibiting matrix metalloproteinase-9. [Abstract]

2024 Jun 1:250:109907. PMID: 38492884
Brain Res Bull

Ginkgolide B alleviates cerebral ischemia-reperfusion injury by antagonizing TRIM45 to reduce microglia-mediated neuronal damage. [Abstract]

2026 Jun 1:239:111854. PMID: 41921864
Hum Genomics

Identifying PTAFR as a hub gene in atherosclerosis: implications for NETosis and disease progression. [Abstract]

2024 Dec 21;18(1):139. PMID: 39709510
Bone

Inhibiting autophagy further promotes Ginkgolide B's anti-osteoclastogenesis ability. [Abstract]

2024 Nov 29:192:117348. PMID: 39617111
Toxicol Appl Pharmacol

Ginkgolide B binds to GPX4 and FSP1 to alleviate cerebral ischemia/reperfusion injury in rats. [Abstract]

2025 Jan 22:495:117237. PMID: 39855311
Biomed Pharmacother

Antagonizing epigenetically controlled PAF/PAF-R pathway improves liver function during experimental cirrhosis. [Abstract]

2025 Nov 20:193:118804. PMID: 41270474

Ginkgolide B purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Nov 20:193:118804. [Abstract]

Representative images of western blot of whole liver lysates from control and cirrhotic mice intraperitoneally injected with Ginkgolide B (BN-52021) (15 mg/kg; i.p.; three times a week for 2 weeks) or DMSO as vehicle, both diluted in sterile PBS; and band densitometry of PAF-R signal with relative quantification respect to loading control β-actin.

Ginkgolide B purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Nov 20:193:118804. [Abstract]

mRNA relative expression of Tbxa2r, Tbxas1, Edn1, Vwf in mice total liver homogenates respect to housekeeping gene β-actin. Ginkgolide B (BN-52021) (15 mg/kg; i.p.; three times a week for 2 weeks) improved endothelial function in cirrhotic mice by antagonizing PAF, as evidenced by significantly reduced expression levels of Tbxa2r, Tbxas1, Edn1, and Vwf.

Ginkgolide B purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2025 Nov 20:193:118804. [Abstract]

mRNA relative expression, normalized to housekeeping gene β-actin of Rorc. Respectively, representative images of RorγT staining in liver and their respective quantifications are shown in the same panels. Signal from the immunohistochemistry staining experiments was blindly measured as number of positive cells/mm² (pointed by arrowheads) in user-specified regions of interest (ROIs) as brown stained nuclear signals colocalizing with blue haematoxylin-stained nuclei. Scale bar = 100 µm. The results showed that the expression of RorgTand the number of RorgT⁺ cells were significantly reduced in the livers of Ginkgolide B (BN-52021) (15 mg/kg; i.p.; three times a week for 2 weeks)-treated cirrhotic mice compared with untreated cirrhotic controls.
Biomed Pharmacother

Ginkgolide B effectively mitigates neuropathic pain by suppressing the activation of the NLRP3 inflammasome through the induction of mitophagy in rats. [Abstract]

2024 Jun 21:177:117006. PMID: 38908197

Ginkgolide B purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Jun 21:177:117006. [Abstract]

The effects of varying Ginkgolide B (GB) concentrations (5, 10, 20, 30, 40, 50, 100, 200, and 400 μM) for 24 h on microglial cell viability (n=6) were assessed.

Ginkgolide B purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Jun 21:177:117006. [Abstract]

HE staining images of the heart, liver, spleen, lungs, kidneys, and brain of rats intraperitoneally injected with 4 mg/kg Ginkgolide B (GB) (twice daily) or 10 mg/kg gabapentin were used to assess drug toxicity. Scale bar = 50 μm (n=3). H&E staining of animal models s confirmed that the therapeutic concentration of GB exerted no drug toxicity.

Ginkgolide B purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Jun 21:177:117006. [Abstract]

Immunohistochemical images and quantification of Iba-1 in the dorsal horn of the spinal cord of rats intraperitoneally injected with 4 mg/kg Ginkgolide B (GB) (twice daily) or 10 mg/kg gabapentin. Scale bar = 100 μm (n=3).

Ginkgolide B purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Jun 21:177:117006. [Abstract]

Ginkgolide B (GB, 1–4 mg/kg, i.p.) suppressed the levels of IL-1β, Caspase-1, IL-18, Iba-1, and NLRP3 in a dose-dependent manner in the rat spinal cord.

Ginkgolide B purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2024 Jun 21:177:117006. [Abstract]

Immunofluorescence images of co-localisation of ASC (green) and NLRP3 (red) in microglial cells after pretreatment with LPS (500 ng/mL; 4 h), ATP (5 mM; 10 min), Ginkgolide B (GB) (40 μM; 2 h) or Si-Parkin. Scale bar = 25 μm (n=3).
Research Square Print

2022 Jun.

溶剤 & 溶解度

体外:

DMSO : ≥ 100 mg/mL (235.63 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3563 mL

11.7813 mL

23.5627 mL

5 mM

0.4713 mL

2.3563 mL

4.7125 mL

10 mM

0.2356 mL

1.1781 mL

2.3563 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (5.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (5.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (5.89 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 0.5% CMC-Na/saline water

Solubility: 5 mg/mL (11.78 mM); Suspended solution; Need ultrasonic and warming and heat to 44°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (283 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Tao Zhou, et al. Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation. Acta Pharmacol Sin. 2016 Feb;37(2):177-86. [Content Brief]

[2]. Pei-Dong Zheng, et al. Ginkgolide B promotes the proliferation and differentiation of neural stem cells following cerebral ischemia/reperfusion injury, both in vivo and in vitro. Neural Regen Res. 2018 Jul;13(7):1204-1211. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3563 mL	11.7813 mL	23.5627 mL	58.9067 mL
	5 mM	0.4713 mL	2.3563 mL	4.7125 mL	11.7813 mL
	10 mM	0.2356 mL	1.1781 mL	2.3563 mL	5.8907 mL
	15 mM	0.1571 mL	0.7854 mL	1.5708 mL	3.9271 mL
	20 mM	0.1178 mL	0.5891 mL	1.1781 mL	2.9453 mL
	25 mM	0.0943 mL	0.4713 mL	0.9425 mL	2.3563 mL
	30 mM	0.0785 mL	0.3927 mL	0.7854 mL	1.9636 mL
	40 mM	0.0589 mL	0.2945 mL	0.5891 mL	1.4727 mL
	50 mM	0.0471 mL	0.2356 mL	0.4713 mL	1.1781 mL
	60 mM	0.0393 mL	0.1964 mL	0.3927 mL	0.9818 mL
	80 mM	0.0295 mL	0.1473 mL	0.2945 mL	0.7363 mL
	100 mM	0.0236 mL	0.1178 mL	0.2356 mL	0.5891 mL

Ginkgolide B

13 Cited Publications

100 mg お問い合わせ

Subscribe to the

MedChemExpress

Newsletter

製品名:
製品番号:
数量:
日本の代理先をお選びください:

製品名:
CAS 番号:
生物種:
純度:
数量:

Ginkgolide B

Apoptosis Compound Library

GPCR/G Protein Compound Library

Immunology/Inflammation Compound Library

Natural Product Library

Anti-Cancer Compound Library

CNS-Penetrant Compound Library

Lipid Compound Library

Anti-Cardiovascular Disease Compound Library

Medicine Food Homology Compound Library

Terpenoids Library

Traditional Chinese Medicine Active Compound Library

Neuroprotective Compound Library

Food-Sourced Compound Library

Rare Diseases Drug Library

Anti-Cancer Natural Product Library

Anti-inflammatory Traditional Chinese Medicine Active Compound Library

Plant-Sourced Natural Product Library

Human Metabolite Library

Coagulation and Anti-coagulation Compound Library

Membrane Protein-targeted Compound Library

Membrane Receptor-targeted Compound Library

Cell Death Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library

Flavor Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Ancient Chinese Classical Formulas Traditional Chinese Medicine Active Compound Library

Mass Spectrometry Human Metabolite Library

Antitussive and Antiasthmatic Traditional Chinese Medicine Active Compound Library

Diarrhea-Related Traditional Chinese Medicine Active Compound Library

Natural Product Diversity Scaffold Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

MedChemExpress（MCE）の使用を引用している文献 Ginkgolide B

生物活性

化学情報

Publications (13)

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Ginkgolide B 関連分類

HY-N0784 関連分類