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Based on 16 publication(s) in Google Scholar
Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.
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- 純度: 99.96%
- CAS 番号: 68-94-0
- 分子式: C5H4N4O
- 分子量:136.11
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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- 純度とドキュメンテーション
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MedChemExpress（MCE）の使用を引用している文献 Hypoxanthine
More- Nature. 2025 Jul;643(8070):192-200. [Abstract]
- Cell Death Differ. 2026 Jan 24. [Abstract]
- Asian J Pharm Sci. 2026 Apr;21(2):101150. [Abstract]
- Med. 2026 Mar 27:101078. [Abstract]
- Cancer Lett. 2025 Sep 29:634:218069. [Abstract]
- J Transl Med. 2024 Feb 21;22(1):192. [Abstract]
- Oncogene. 2025 May;44(16):1078-1092. [Abstract]
- Talanta. 2024 Jan 15:267:125171. [Abstract]
- Mol Ther Oncolytics. 2021 Aug 28:23:107-123. [Abstract]
- Drug Des Devel Ther. 2025 Jul 30:19:6573-6585. [Abstract]
- ACS Chem Neurosci. 2024 Nov 6;15(21):3970-3980. [Abstract]
- BMC Neurol. 2023 Dec 16;23(1):444. [Abstract]
- bioRxiv. 2026 May 6.
- bioRxiv. 2025 Nov 20.
- bioRxiv. 2025 Oct 14.
- Research Square Preprint. 2022 Feb.
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Endogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
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Microbial Metabolite |
Human Endogenous Metabolite |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-431 | IC50 |
>100 μg/mL
Compound: hypoxanthine
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Inhibition of phosphatidylinositol 4-kinase in human A431 cell membrane by liquid scintillation counting
Inhibition of phosphatidylinositol 4-kinase in human A431 cell membrane by liquid scintillation counting
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[PMID: 1666120] |
Hypoxanthine is a potential free radical generator. Hypoxanthine seems to play a role in posthypoxic reoxygenation cell injury through oxygen radical production and is therefore involved in the pathogenesis of a number of diseases. Hypoxanthine also modulates a number of other processes because it reacts with benzodiazepine receptors and inhibits phosphodiesterase in the brain. Hypoxanthine inhibits the effect of several cytotoxic drugs and may therefore influence treatment with such drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 68-94-0
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性状 Solid
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分子量 136.11
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分子式 C5H4N4O
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Color Off-white to pink
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SMILES
O=C1NC=NC2=C1N=CN2
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別名
Hypoxanthine; Purin-6-ol; Sarcine
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Structure Classification
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Initial Source
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (16)
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Journal Impact Factor
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Most Recent
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Nature
2025 Jul;643(8070):192-200. PMID: 39695227 -
Cell Death Differ
CARM1-mediated hypoxanthine-enriched exosomes rewire inosine metabolism and impair CD8+ T cell antitumor function. [Abstract]2026 Jan 24. PMID: 41580530 -
Asian J Pharm Sci
A programmable nanoreactor for photothermal immunotherapy via NIR-II triggered enzyme-catalyzed immunogenic tumor microenvironment remodeling. [Abstract]2026 Apr;21(2):101150. PMID: 42023164 -
Med
Large-scale quantitative metabolomics and mass spectrometry imaging define the metabolic atlas in human acute type A aortic dissection. [Abstract]2026 Mar 27:101078. PMID: 41903544 -
Cancer Lett
2025 Sep 29:634:218069. PMID: 41033606
Hypoxanthine purchased from MedChemExpress. Usage Cited in: Cancer Lett. 2025 Sep 29:634:218069. [Abstract]
Relative cell viability of PC-9 cells supplementing with inosine, adenosine, or hypoxanthine treated with osimertinib for 120 h.
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J Transl Med
ZSWIM4 inhibition improves chemosensitivity in epithelial ovarian cancer cells by suppressing intracellular glycine biosynthesis. [Abstract]2024 Feb 21;22(1):192. PMID: 38383406
Hypoxanthine purchased from MedChemExpress. Usage Cited in: J Transl Med. 2024 Feb 21;22(1):192. [Abstract]
Rescue experiments using exogenous supplementation of hypoxanthine (100 µM) and GSH in ZSWIM4-knockdown OVCAR8 cells.
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Oncogene
The protection of UCK2 protein stability by GART maintains pyrimidine salvage synthesis for HCC growth under glucose limitation. [Abstract]2025 May;44(16):1078-1092. PMID: 39865175
Hypoxanthine purchased from MedChemExpress. Usage Cited in: Oncogene. 2025 May;44(16):1078-1092. [Abstract]
MHCC-97H cells with or without depletion of GART were treated with or without exogenous hypoxanthine (100 mM). Cell viability was examined by CCK-8 assay.
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Talanta
A simple, rapid and sensitive HILIC LC-MS/MS method for simultaneous determination of 16 purine metabolites in plasma and urine. [Abstract]2024 Jan 15:267:125171. PMID: 37696233 -
Mol Ther Oncolytics
Oleanolic acid blocks the purine salvage pathway for cancer therapy by inactivating SOD1 and stimulating lysosomal proteolysis. [Abstract]2021 Aug 28:23:107-123. PMID: 34703880
Hypoxanthine purchased from MedChemExpress. Usage Cited in: Mol Ther Oncolytics. 2021 Aug 28:23:107-123. [Abstract]
DNA replication arrest of cancer cells induced by OA treatment (200 mM) was restored by exogenous supplementation of hypoxanthine (Hyp) (100 mM) (E) for 8 h.
Hypoxanthine purchased from MedChemExpress. Usage Cited in: Mol Ther Oncolytics. 2021 Aug 28:23:107-123. [Abstract]
Proliferating cell nuclear antigen (PCNA) expression induced by 200 mM OA treatment was recovered by exogenous supplementation of inosine or hypoxanthine (Hyp) (100 mM).
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Drug Des Devel Ther
17(R)-RvD1 Ameliorates Liver Injury in Hyperuricemia Through Inhibiting Pyroptosis via NF-κB Signaling Pathway. [Abstract]2025 Jul 30:19:6573-6585. PMID: 40756265 -
ACS Chem Neurosci
Hypoxanthine Produces Rapid Antidepressant Effects by Suppressing Inflammation in Serum and Hippocampus. [Abstract]2024 Nov 6;15(21):3970-3980. PMID: 39441118 -
BMC Neurol
Integrative analysis of purine metabolites and gut microbiota in patients with neuromyelitis optica spectrum disorders after mycophenolate mofetil treatment. [Abstract]2023 Dec 16;23(1):444. PMID: 38102573 -
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溶剤 & 溶解度
DMSO : 10 mg/mL (73.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1 mg/mL (7.35 mM); Clear solution
This protocol yields a clear solution of ≥ 1 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (10.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 0.5% CMC-Na/saline water
Solubility: 25 mg/mL (183.67 mM); Suspended solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
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参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 7.3470 mL | 36.7350 mL | 73.4700 mL | 183.6750 mL |
| 5 mM | 1.4694 mL | 7.3470 mL | 14.6940 mL | 36.7350 mL | |
| 10 mM | 0.7347 mL | 3.6735 mL | 7.3470 mL | 18.3675 mL | |
| 15 mM | 0.4898 mL | 2.4490 mL | 4.8980 mL | 12.2450 mL | |
| 20 mM | 0.3673 mL | 1.8367 mL | 3.6735 mL | 9.1837 mL | |
| 25 mM | 0.2939 mL | 1.4694 mL | 2.9388 mL | 7.3470 mL | |
| 30 mM | 0.2449 mL | 1.2245 mL | 2.4490 mL | 6.1225 mL | |
| 40 mM | 0.1837 mL | 0.9184 mL | 1.8367 mL | 4.5919 mL | |
| 50 mM | 0.1469 mL | 0.7347 mL | 1.4694 mL | 3.6735 mL | |
| 60 mM | 0.1224 mL | 0.6122 mL | 1.2245 mL | 3.0612 mL |
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